CYP26A1

CYP26A1
معرفات
أسماء بديلة	CYP26A1,CP26, CYP26, P450RAI, P450RAI1, cytochrome P450 family 26 subfamily A member 1
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت602239MGI:MGI:1096359HomoloGene:37349GeneCards:1592
علم الوجود الجيني وظائف جزيئية •ربط أيون الحديد •oxygen binding •oxidoreductase activity •retinoic acid binding •heme binding •‏GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen •ربط أيون فلزي •monooxygenase activity •oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen •retinoic acid 4-hydroxylase activity مكونات خلوية •organelle membrane •endoplasmic reticulum membrane •شبكة إندوبلازمية •غشاء •intracellular membrane-bounded organelle عمليات حيوية •negative regulation of retinoic acid receptor signaling pathway •retinoic acid catabolic process •vitamin metabolic process •xenobiotic metabolic process •sterol metabolic process •response to retinoic acid •response to vitamin A •retinoic acid metabolic process •تطور الكلى المصادر:Amigo/QuickGO
نمط التعبير عن الحمض النووي الريبوزي
المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
أنواع	الإنسان	الفأر
أنتريه	1592	13082
Ensembl	ENSG00000095596	ENSMUSG00000024987
يونيبروت	O43174	O55127
RefSeq (رنا مرسال.)	‏NM_000783 NM_057157، ‏NM_000783	‏XM_017318053 NM_007811، ‏XM_017318053
RefSeq(بروتين)	‏NP_476498 NP_000774، ‏NP_476498	‏XP_017173542 NP_031837، ‏XP_017173542
الموقع (UCSC	n/a	Chr 19: 37.69 – 37.69 Mb
بحثببمد	[1]	[2]
ويكي بيانات
اعرض/عدّل إنسان اعرض/عدّل فأر

CYP26A1‏ (Cytochrome P450 family 26 subfamily A member 1) هوَبروتينيُشَفربواسطةجينCYP26A1 فيالإنسان.

قراءة متعمقة

• Duell EA، Kang S، Voorhees JJ (فبراير 1996)."Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid".The Journal of Investigative Dermatology.ج. 106 ع. 2: 316–20.DOI:10.1111/1523-1747.ep12342972.PMID:8601734.
• Ray WJ، Bain G، Yao M، Gottlieb DI (يوليو 1997). "CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family".The Journal of Biological Chemistry.ج. 272 ع. 30: 18702–8.DOI:10.1074/jbc.272.30.18702.PMID:9228041.{{استشهاد بدورية محكمة}}:صيانة الاستشهاد: دوي مجاني غير معلم (link)
• Sonneveld E، van den Brink CE، van der Leede BM، Schulkes RK، Petkovich M، van der Burg B، van der Saag PT (أغسطس 1998). "Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells".Cell Growth & Differentiation.ج. 9 ع. 8: 629–37.PMID:9716180.
• Trofimova-Griffin ME، Juchau MR (نوفمبر 1998). "Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues".Biochemical and Biophysical Research Communications.ج. 252 ع. 2: 487–91.DOI:10.1006/bbrc.1998.9659.PMID:9826557.
• Popa C، Dicker AJ، Dahler AL، Saunders NA (سبتمبر 1999)."Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible".The British Journal of Dermatology.ج. 141 ع. 3: 460–8.DOI:10.1046/j.1365-2133.1999.03039.x.PMID:10583049.
• McSorley LC، Daly AK (أغسطس 2000). "Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation".Biochemical Pharmacology.ج. 60 ع. 4: 517–26.DOI:10.1016/S0006-2952(00)00356-7.PMID:10874126.
• Loudig O، Babichuk C، White J، Abu-Abed S، Mueller C، Petkovich M (سبتمبر 2000). "Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism".Molecular Endocrinology.ج. 14 ع. 9: 1483–97.DOI:10.1210/me.14.9.1483.PMID:10976925.
• Deng L، Shipley GL، Loose-Mitchell DS، Stancel GM، Broaddus R، Pickar JH، Davies PJ (مايو 2003). "Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium".The Journal of Clinical Endocrinology and Metabolism.ج. 88 ع. 5: 2157–63.DOI:10.1210/jc.2002-021844.PMID:12727970.
• Won JY، Nam EC، Yoo SJ، Kwon HJ، Um SJ، Han HS، Kim SH، Byun Y، Kim SY (أغسطس 2004). "The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma".Metabolism.ج. 53 ع. 8: 1007–12.DOI:10.1016/j.metabol.2003.12.015.PMID:15281009.
• Loudig O، Maclean GA، Dore NL، Luu L، Petkovich M (نوفمبر 2005)."Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility".The Biochemical Journal.ج. 392 ع. Pt 1: 241–8.DOI:10.1042/BJ20050874.PMC:1317683.PMID:16053444.
• Ozpolat B، Mehta K، Lopez-Berestein G (أكتوبر 2005). "Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells".Leukemia & Lymphoma.ج. 46 ع. 10: 1497–506.DOI:10.1080/10428190500174737.PMID:16194896.
• Heise R، Mey J، Neis MM، Marquardt Y، Joussen S، Ott H، Wiederholt T، Kurschat P،Megahed M، Bickers DR، Merk HF، Baron JM (نوفمبر 2006). "Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models".The Journal of Investigative Dermatology.ج. 126 ع. 11: 2473–80.DOI:10.1038/sj.jid.5700432.PMID:16778795.
• Rat E، Billaut-Laden I، Allorge D، Lo-Guidice JM، Tellier M، Cauffiez C، Jonckheere N، van Seuningen I، Lhermitte M، Romano A، Guéant JL، Broly F (يونيو 2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida".Birth Defects Research. Part A, Clinical and Molecular Teratology.ج. 76 ع. 6: 491–8.DOI:10.1002/bdra.20275.PMID:16933217.
• Gomaa MS، Yee SW، Milbourne CE، Barbera MC، Simons C، Brancale A (أغسطس 2006). "Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding".Journal of Enzyme Inhibition and Medicinal Chemistry.ج. 21 ع. 4: 361–9.DOI:10.1080/14756360600742014.PMID:17059167.
• Quere R، Baudet A، Cassinat B، Bertrand G، Marti J، Manchon L، Piquemal D، Chomienne C، Commes T (مايو 2007). "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity".Blood.ج. 109 ع. 10: 4450–60.DOI:10.1182/blood-2006-10-051086.PMID:17218384.
• Lee SJ، Perera L، Coulter SJ، Mohrenweiser HW، Jetten A، Goldstein JA (مارس 2007)."The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system".Pharmacogenetics and Genomics.ج. 17 ع. 3: 169–80.DOI:10.1097/FPC.0b013e32801152d6.PMC:2393551.PMID:17460545.