DPPA3

DPPA3
Identifikatori
Aliasi	DPPA3
Vanjski ID-jevi	OMIM:608408HomoloGene:138483GeneCards:DPPA3
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12p13.31 Početak 7,711,433bp Kraj 7,717,559bp
Ontologija gena Molekularna funkcija •methylated histone binding Ćelijska komponenta •male pronucleus •citoplazma •jedro •female pronucleus Biološki proces •multicellular organism development •protection of DNA demethylation of female pronucleus •negative regulation of DNA demethylation •regulation of genetic imprinting •GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Izvori:Amigo/QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	359787	n/a
Ensembl	ENSG00000187569	n/a
UniProt	Q6W0C5	n/a
RefSeq (mRNK)	NM_199286	n/a
RefSeq (bjelančevina)	NP_954980	n/a
Lokacija (UCSC)	Chr 12: 7.71 – 7.72 Mb	n/a
PubMedpretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Protein 3 sa razvojnom pluripotencijomjeproteinkoji je kodljudikodirangenomDPPA3.

Ovaj gen kodira protein koji kod miševa može funkcionirati kao majčinski faktor u preimplantacijskoj fazi razvoja. Kod njih ovaj gen može imati ulogu u transkripcijskoj represiji,ćelijskoj diobii održavanjupluripotenostićelija. Kod ljudi, srodnibezintronskilokusi nalaze se nahromosomima 14iX.

Aminokiselinska sekvenca

Dužinapolipeptidnoglanca je 150aminokiselina,amolekulska težina17 851Da..

10		20		30		40		50
MDPSQFNPTY		IPGSPQMLTE		ENSRDDSGAS		QISSETLIKN		LSNLTINASS
ESVSPLSEAL		LRRESVGAAV		LREIEDEWLY		SRRGVRTLLS		VQREKMARLR
YMLLGGVRTH		ERRPTNKEPK		GVKKESRPFK		CPCSFCVSNG		WDPSENARIG
NQDTKPLQP

Simboli

C:Cistein
D:Asparaginska kiselina
E:Glutaminska kiselina
F:Fenilalanin
G:Glicin
H:Histidin
I:Izoleucin
K:Lizin
L:Leucin
M:Metionin
N:Asparagin
P:Prolin
Q:Glutamin
R:Arginin
S:Serin
T:Treonin
V:Valin
W:Triptofan
Y:Tirozin

Dopunska literatura

• Nakamura T, Arai Y, Umehara H, et al. (2007). "PGC7/Stella protects against DNA demethylation in early embryogenesis".Nat. Cell Biol.9(1): 64–71.doi:10.1038/ncb1519.PMID17143267.S2CID1947132.
• Elliman SJ, Wu I, Kemp DM (2006)."Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin".J. Biol. Chem.281(1): 16–9.doi:10.1074/jbc.C500415200.PMID16291741.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Bortvin A, Goodheart M, Liao M, Page DC (2004)."Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice".BMC Dev. Biol.4:2.doi:10.1186/1471-213X-4-2.PMC362866.PMID15018652.
• Clark AT, Rodriguez RT, Bodnar MS, et al. (2004)."Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma".Stem Cells.22(2): 169–79.doi:10.1634/stemcells.22-2-169.PMID14990856.S2CID38136098.
• Bowles J, Teasdale RP, James K, Koopman P (2004). "Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours".Cytogenet. Genome Res.101(3–4): 261–5.doi:10.1159/000074346.PMID14684992.S2CID7005986.
• Payer B, Saitou M, Barton SC, et al. (2004)."Stella is a maternal effect gene required for normal early development in mice".Curr. Biol.13(23): 2110–7.doi:10.1016/j.cub.2003.11.026.PMID14654002.S2CID2010581.
• Sato M, Kimura T, Kurokawa K, et al. (2002)."Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells".Mech. Dev.113(1): 91–4.doi:10.1016/S0925-4773(02)00002-3.PMID11900980.S2CID12877378.