EXTL2
Izgled
Egzostozinoliki protein 2jestproteinkoji je kodljudikodirangenomEXTL2sahromosoma 1.[5][6][7]
Amiokiselininska sekvenca[uredi|uredi izvor]
Dužinapolipeptidnoglanca je 330aminokiselina,amolekulska težina37.466Da.[8]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MRCCHICKLP | GRVMGIRVLR | LSLVVILVLL | LVAGALTALL | PSVKEDKMLM | ||||
LRREIKSQGK | STMDSFTLIM | QTYNRTDLLL | KLLNHYQAVP | NLHKVIVVWN | ||||
NIGEKAPDEL | WNSLGPHPIP | VIFKQQTANR | MRNRLQVFPE | LETNAVLMVD | ||||
DDTLISTPDL | VFAFSVWQQF | PDQIVGFVPR | KHVSTSSGIY | SYGSFEMQAP | ||||
GSGNGDQYSM | VLIGASFFNS | KYLELFQRQP | AAVHALIDDT | QNCDDIAMNF | ||||
IIAKHIGKTS | GIFVKPVNMD | NLEKETNSGY | SGMWHRAEHA | LQRSYCINKL | ||||
VNIYDSMPLR | YSNIMISQFG | FPYANYKRKI |
Funkcija[uredi|uredi izvor]
EXTL2 glikoziltransferazapotrebna je zabiosintezuheparan-sulfata i odgovorna je za naizmjenično dodavanje beta-1-4-vezane glukuronske kiseline (GlcA) i alfa-1-4-vezanih N-acetilglukozamin (GlcNAc) jedinica u nastajajuće heparan-sulfatne lance. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)
Reference[uredi|uredi izvor]
- ^abcGRCh38: Ensembl release 89: ENSG00000162694-Ensembl,maj 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000027963-Ensembl,maj 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2".Eur J Hum Genet.5(6): 382–9.doi:10.1159/000484796.PMID9450183.
- ^Sobhany M, Dong J, Negishi M (Jun 2005)."Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase".J Biol Chem.280(25): 23441–5.doi:10.1074/jbc.M413379200.PMID15831490.
- ^"Entrez Gene: EXTL2 exostoses (multiple)-like 2".
- ^"UniProt, Q9UBQ6"(jezik: engleski).Pristupljeno 25. 11. 2021.
Dopunska literatura[uredi|uredi izvor]
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- McCormick C, Duncan G, Goutsos KT, Tufaro F (2000)."The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate".Proc. Natl. Acad. Sci. U.S.A.97(2): 668–73.Bibcode:2000PNAS...97..668M.doi:10.1073/pnas.97.2.668.PMC15388.PMID10639137.
- Kitagawa H, Shimakawa H, Sugahara K (1999)."The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate".J. Biol. Chem.274(20): 13933–7.doi:10.1074/jbc.274.20.13933.PMID10318803.
- Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family".Biochem. Biophys. Res. Commun.243(1): 61–6.doi:10.1006/bbrc.1997.8062.PMID9473480.
- Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6(9): 791–806.doi:10.1101/gr.6.9.791.PMID8889548.
Vanjski linkovi[uredi|uredi izvor]
- PDBe-KBprovides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2