S Wikipedije, slobodne enciklopedije
Ćelijskopovršinskiantigen A33 jestprotein koji je kodljudi kodiran genom GPA33 sahromosoma 1 .[5] [6] [7]
Dužinapolipeptidnog lanca je 319aminokiselina ,amolekulska težina 35.632Da .[8]
10 20 30 40 50 MVGKMWPVLW TLCAVRVTVD AISVETPQDV LRASQGKSVT LPCTYHTSTS SREGLIQWDK LLLTHTERVV IWPFSNKNYI HGELYKNRVS ISNNAEQSDA SITIDQLTMA DNGTYECSVS LMSDLEGNTK SRVRLLVLVP PSKPECGIEG ETIIGNNIQL TCQSKEGSPT PQYSWKRYNI LNQEQPLAQP ASGQPVSLKN ISTDTSGYYI CTSSNEEGTQ FCNITVAVRS PSMNVALYVG IAVGVVAALI IIGIIIYCCC CRGKDDNTED KEDARPNREA YEEPPEQLRE LSREREEEDD YRQEEQRSTG RESPDHLDQ
Glikoprotein kodiran ovim genom jeantigen ćelijske površine koji je eksprimiran u više od 95% ljudskihkarcinom debelog crijeva .Otvoreni okvir čitanja kodira polipeptid od 319 aminokiselina koji ima navodnu sekretornusignalnu sekvencu i tri potencijalna mjestaglikozilacije .Predviđeni zreli protein ima vanćelijsku regiju od 213 aminokiselina, jedantransmembranski domen i unutarćelijski rep od 62 aminokiseline. Sekvenca vanćelijskog regiona sadrži dva domena karakteristična za CD2 podgrupu natporodiceimunoglobulina (Ig).[7]
^a b c GRCh38: Ensembl release 89: ENSG00000143167 -Ensembl ,maj 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000000544 -Ensembl ,maj 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997)."The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily" .Proc Natl Acad Sci U S A .94 (2): 469–74.Bibcode :1997PNAS...94..469H .doi :10.1073/pnas.94.2.469 PMC 19536 PMID 9012807 . ^ Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium".Biochem Biophys Res Commun .236 (3): 682–6.doi :10.1006/bbrc.1997.6966 .PMID 9245713 . ^a b "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)" .^ "UniProt, Q99795" (jezik: en.).Pristupljeno 11. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
Hwang SH, Sohn YH, Oh HB, et al. (2007)."Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans" .Arch. Pathol. Lab. Med .131 (1): 117–21.doi :10.5858/2007-131-117-HLAAAH .PMID 17227111 . [mrtav link Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" .Genome Res .14 (10B): 2121–7.doi :10.1101/gr.2596504 .PMC 528928 PMID 15489334 . Mao Z, Song S, Zhu Y, et al. (2003)."Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor" .Oncogene .22 (28): 4434–43.doi :10.1038/sj.onc.1206508 PMID 12853980 .S2CID 38283384 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26): 16899–903.doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Johnstone CN, White SJ, Tebbutt NC, et al. (2002)."Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression" .J. Biol. Chem .277 (37): 34531–9.doi :10.1074/jbc.M204865200 PMID 12114523 .S2CID 36386508 . Moritz RL, Ritter G, Catimel B, et al. (1998). "Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium".Journal of Chromatography A .798 (1–2): 91–101.doi :10.1016/S0021-9673(97)01031-5 .PMID 9542130 .
GPA33 UCSC Genome Browser .
