DPF2

DPF2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3IUF
Identifikatori
Aliasi	DPF2
Vanjski ID-jevi	OMIM: 601671 MGI: 109529 HomoloGene: 21265 GeneCards: DPF2
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	65,354,262 bp
Lokacija gena (miš)
Hrom.	Hromosom 19 (miš)
Kraj	5,963,038 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001106 transcription corepressor activity; • histone acetyltransferase activity; • GO:0031493 histone binding; • H3K9me3 modified histone binding; • lysine-acetylated histone binding;
Ćelijska komponenta	• jedro; • nukleoplazma; • intracellular membrane-bounded organelle; • centrosom; • citoplazma; • citosol; • histone acetyltransferase complex; • nBAF complex;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • apoptotic signaling pathway; • GO:0097285 apoptoza; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • nervous system development; • histone acetylation; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of myeloid progenitor cell differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	5977
	19708
	ENSG00000133884
	ENSMUSG00000024826
	Q92785
	Q61103
	NM_006268; NM_001330308
	NM_001291078; NM_011262
	NP_001317237; NP_006259; NP_006259.1
	NP_001278007; NP_035392
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein cinkovog prsta ubi-d4 je protein koji je kosd ljudi koodiran genom DPF2.^[5]^[6]

Protein kodiran ovim genom član je porodice domena d4, karakteriziran strukturnim motivom sličnim cinkovim prstima. Ovaj protein funkcionira kao transkripcijski faktor koji je neophodan za apoptotski odgovor nakon uskraćivanja faktora preživljavanja. Vjerojatno ima regulatornu ulogu u brzom hematopoetskim rastu i čelijskom prometu. Ovaj gen se smatra kandidatskim genom za multiplu endokrinu neoplaziju tip I, nasljedni kancerski sindrom koji uključuje višestruke paratiroidne, enteropankreasne i hipofizne tumore.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 391 aminokiselina, a molekulska težina 44.155 Da.^[7]

10	20	30	40	50
MAAVVENVVK	LLGEQYYKDA	MEQCHNYNAR	LCAERSVRLP	FLDSQTGVAQ
SNCYIWMEKR	HRGPGLASGQ	LYSYPARRWR	KKRRAHPPED	PRLSFPSIKP
DTDQTLKKEG	LISQDGSSLE	ALLRTDPLEK	RGAPDPRVDD	DSLGEFPVTN
SRARKRILEP	DDFLDDLDDE	DYEEDTPKRR	GKGKSKGKGV	GSARKKLDAS
ILEDRDKPYA	CDICGKRYKN	RPGLSYHYAH	SHLAEEEGED	KEDSQPPTPV
SQRSEEQKSK	KGPDGLALPN	NYCDFCLGDS	KINKKTGQPE	ELVSCSDCGR
SGHPSCLQFT	PVMMAAVKTY	RWQCIECKCC	NICGTSENDD	QLLFCDDCDR
GYHMYCLTPS	MSEPPEGSWS	CHLCLDLLKE	KASIYQNQNS	S

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
^ ^a ^b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".
^ "UniProt, Q92785". Pristupljeno 21. 8. 2021.

Dopunska litertura

Gabig TG, Mantel PL, Rosli R, Crean CD (1994). "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells". J. Biol. Chem. 269 (47): 29515–9. doi:10.1016/S0021-9258(18)43910-5. PMID 7961935.
Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics. 36 (1): 174–7. doi:10.1006/geno.1996.0440. PMID 8812431.
Guru SC, Agarwal SK, Manickam P, et al. (1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome. 9 (8): 660–5. doi:10.1007/s003359900840. PMID 9680388. S2CID 22559464.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

DPF2 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11845289-5] Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.

[entrez-6] "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

[UniProt-7] "UniProt, Q92785". Pristupljeno 21. 8. 2021.

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