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Mikrofibrilski-pridruženi protein 5 je protein koji je kod ljudi kodiran genom MFAP5 .[ 5] [ 6] [ 7]
Ovaj gen kodira glikoprotein od 25-kD, povezan s mikrofibrilama koji je bogat ostacima serina i treonina . Nedostaju mu hidrofobne regije C-krajevi bogati prolinom , glutaminom i tirozinom , što je karakteristika srodnog glikoproteina povezanog s mikrofibrilom od 31 kDa (MFAP2). Bliska sličnost između ova dva proteina ograničena je na centralno područje od 60 aminokiselina, gdje dolazi do preciznog poravnanja sedam ostataka cisteina . Strukturne razlike ukazuju na to da ovaj kodirani protein ima neke funkcije koje se razlikuju od funkcija MFAP2.[ 7]
Dužina polipeptidnog lanca je 173 aminokiseline , a molekulska težina 19.612 Da .[ 8]
10 20 30 40 50 MSLLGPKVLL FLAAFIITSD WIPLGVNSQR GDDVTQATPE TFTEDPNLVN DPATDETVLA VLADIAPSTD DLASLSEKNT TAECWDEKFT CTRLYSVHRP VKQCIHQLCF TSLRRMYIVN KEICSRLVCK EHEAMKDELC RQMAGLPPRR LRRSNYFRLP PCENVDLQRP NGL
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^ a b c GRCh38: Ensembl release 89: ENSG00000197614 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030116 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hatzinikolas G, Gibson MA (Dec 1998). "The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region" . J Biol Chem . 273 (45): 29309–14. doi :10.1074/jbc.273.45.29309 PMID 9792630 . ^ Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nicholl JK, Sutherland GR, Cleary EG (Feb 1996). "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)" . J Biol Chem . 271 (2): 1096–103. doi :10.1074/jbc.271.2.1096 PMID 8557636 . ^ a b "Entrez Gene: MFAP5 microfibrillar associated protein 5" .^ "UniProt, Q13361" . Pristupljeno 11. 8. 2021 .
Miyamoto A, Lau R, Hein PW, et al. (2006). "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation" . J. Biol. Chem . 281 (15): 10089–97. doi :10.1074/jbc.M600298200 PMID 16492672 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res . 288 (1): 35–50. doi :10.1016/S0014-4827(03)00130-7 . PMID 12878157 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Penner AS, Rock MJ, Kielty CM, Shipley JM (2002). "Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly" . J. Biol. Chem . 277 (38): 35044–9. doi :10.1074/jbc.M206363200 PMID 12122015 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . 
