MYO6

MYO6
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2N11, 2N13, 2N0Z, 2N10, 2N12
Identifikatori
Aliasi	MYO6
Vanjski ID-jevi	OMIM: 600970 MGI: 104785 HomoloGene: 56417 GeneCards: MYO6
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	75,919,537 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	80,219,011 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cytoskeletal motor activity; • actin filament binding; • ATP binding; • calmodulin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • minus-end directed microfilament motor activity; • ADP binding; • actin binding; • nucleotide binding; • cadherin binding; • vezivanje identičnih proteina;
Ćelijska komponenta	• myosin complex; • jedro; • intracellular membrane-bounded organelle; • projekcija ćelije; • ruffle membrane; • RNA polymerase II, holoenzyme; • nukleoplazma; • lysosomal membrane; • perinuklearno područje citoplazme; • clathrin-coated endocytic vesicle; • apical part of cell; • clathrin-coated vesicle membrane; • ruffle; • citosol; • Egzosom; • membrana; • clathrin-coated pit; • filamentous actin; • ćelijska membrana; • Jedarna membrana; • citoplazma; • cell cortex; • microvillus; • Golđijev aparat; • unconventional myosin complex; • endocytic vesicle; • GO:0016023 citoplazmatska vezikula; • Mikronit; • GO:0009327 makromolekulani kompleks; • clathrin-coated vesicle; • Filopodija;
Biološki proces	• intracellular protein transport; • actin filament-based movement; • regulation of secretion; • sluh; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • protein transport; • Endocitoza; • DNA damage response, signal transduction by p53 class mediator; • GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	4646
	17920
	ENSG00000196586
	ENSMUSG00000033577
	Q9UM54
	Q64331
NM_001300899; NM_004999; NM_001368136; NM_001368137; NM_001368138;
	NM_001368139; NM_001368140; NM_001368865; NM_001368866
	NM_001039546; NM_008662
NP_001287828; NP_004990; NP_001355065; NP_001355066; NP_001355067;
	NP_001355068; NP_001355069; NP_001355794; NP_001355795
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Miozin VI, znan i kao MYO6, jest protein koji je kod ljudi kodiran genom MYO6, kao i kod miševa vinskih mušica i nematoda (Caenorhabditis elegans).

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.294 aminokiseline, а molekulska težina 149.691 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEDGKPVWAP	HPTDGFQMGN	IVDIGPDSLT	IEPLNQKGKT	FLALINQVFP
AEEDSKKDVE	DNCSLMYLNE	ATLLHNIKVR	YSKDRIYTYV	ANILIAVNPY
FDIPKIYSSE	AIKSYQGKSL	GTRPPHVFAI	ADKAFRDMKV	LKMSQSIIVS
GESGAGKTEN	TKFVLRYLTE	SYGTGQDIDD	RIVEANPLLE	AFGNAKTVRN
NNSSRFGKFV	EIHFNEKSSV	VGGFVSHYLL	EKSRICVQGK	EERNYHIFYR
LCAGASEDIR	EKLHLSSPDN	FRYLNRGCTR	YFANKETDKQ	ILQNRKSPEY
LKAGSMKDPL	LDDHGDFIRM	CTAMKKIGLD	DEEKLDLFRV	VAGVLHLGNI
DFEEAGSTSG	GCNLKNKSAQ	SLEYCAELLG	LDQDDLRVSL	TTRVMLTTAG
GTKGTVIKVP	LKVEQANNAR	DALAKTVYSH	LFDHVVNRVN	QCFPFETSSY
FIGVLDIAGF	EYFEHNSFEQ	FCINYCNEKL	QQFFNERILK	EEQELYQKEG
LGVNEVHYVD	NQDCIDLIEA	KLVGILDILD	EENRLPQPSD	QHFTSAVHQK
HKDHFRLTIP	RKSKLAVHRN	IRDDEGFIIR	HFAGAVCYET	TQFVEKNNDA
LHMSLESLIC	ESRDKFIREL	FESSTNNNKD	TKQKAGKLSF	ISVGNKFKTQ
LNLLLDKLRS	TGASFIRCIK	PNLKMTSHHF	EGAQILSQLQ	CSGMVSVLDL
MQGGYPSRAS	FHELYNMYKK	YMPDKLARLD	PRLFCKALFK	ALGLNENDYK
FGLTKVFFRP	GKFAEFDQIM	KSDPDHLAEL	VKRVNHWLTC	SRWKKVQWCS
LSVIKLKNKI	KYRAEACIKM	QKTIRMWLCK	RRHKPRIDGL	VKVGTLKKRL
DKFNEVVSVL	KDGKPEMNKQ	IKNLEISIDT	LMAKIKSTMM	TQEQIQKEYD
ALVKSSEELL	SALQKKKQQE	EEAERLRRIQ	EEMEKERKRR	EEDEKRRRKE
EEERRMKLEM	EAKRKQEEEE	RKKREDDEKR	IQAEVEAQLA	RQKEEESQQQ
AVLEQERRDR	ELALRIAQSE	AELISDEAQA	DLALRRSLDS	YPVSKNDGTR
PKMTPEQMAK	EMSEFLSRGP	AVLATKAAAG	TKKYDLSKWK	YAELRDTINT
SCDIELLAAC	REEFHRRLKV	YHAWKSKNKK	RNTETEQRAP	KSVTDYDFAP
FLNNSPQQNP	AAQIPARQRE	IEMNRQQRFF	RIPFIRPADQ	YKDPQSKKKG
WWYAHFDGPW	IARQMELHPD	KPPILLVAGK	DDMEMCELNL	EETGLTRKRG
AEILPRQFEE	IWERCGGIQY	LQNAIESRQA	RPTYATAMLQ	SLLK

Funkcija

Miozin VI je molekulski motor uključen u unutarćelijski transport vezikula i organela. To je jedan od takozvanih nekonvencijskih miozina (prema OMIM^[6])

Interakcije

Pokazano je da MYO6 stupa u interakciju sa

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196586 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033577 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt, Q9UM54" (jezik: engleski). Pristupljeno 9. 10. 2021.
^ "Entrez Gene: MYO6 myosin VI".
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Sennacherib L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.
^ Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (maj 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.
^ Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
^ He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ (2016). "Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains". Cell Reports. 14 (11): 2683–94. doi:10.1016/j.celrep.2016.01.079. PMC 4805485. PMID 26971995.
^ Biancospino M, Buel GR, Niño CA, Maspero E, di Perrotolo RS, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S (2019). "Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension". Nature Communications. 10 (1): 4974. Bibcode:2019NatCo..10.4974B. doi:10.1038/s41467-019-12855-6. PMC 6823378. PMID 31672988.

Dopunska literatura

Buss F, Luzio JP, Kendrick-Jones J (Nov 2001). "Myosin VI, a new force in clathrin mediated endocytosis". FEBS Letters. 508 (3): 295–9. doi:10.1016/S0014-5793(01)03065-4. PMID 11728438. S2CID 44995651.
Hasson T (Sep 2003). "Myosin VI: two distinct roles in endocytosis". Journal of Cell Science. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (Dec 1995). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nature Genetics. 11 (4): 369–75. doi:10.1038/ng1295-369. PMID 7493015. S2CID 29467878.
Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA (Aug 1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice". Human Molecular Genetics. 6 (8): 1225–31. doi:10.1093/hmg/6.8.1225. PMID 9259267.
Buss F, Kendrick-Jones J, Lionne C, Knight AE, Côté GP, Paul Luzio J (Dec 1998). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation". The Journal of Cell Biology. 143 (6): 1535–45. doi:10.1083/jcb.143.6.1535. PMC 2132970. PMID 9852149.
Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (Sep 1999). "Myosin VI is an actin-based motor that moves backwards". Nature. 401 (6752): 505–8. Bibcode:1999Natur.401..505W. doi:10.1038/46835. PMID 10519557. S2CID 1420305.
Buss F, Arden SD, Lindsay M, Luzio JP, Kendrick-Jones J (Jul 2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". The EMBO Journal. 20 (14): 3676–84. doi:10.1093/emboj/20.14.3676. PMC 125554. PMID 11447109.
Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P (Sep 2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss". American Journal of Human Genetics. 69 (3): 635–40. doi:10.1086/323156. PMC 1235492. PMID 11468689.
Yoshimura M, Homma K, Saito J, Inoue A, Ikebe R, Ikebe M (Oct 2001). "Dual regulation of mammalian myosin VI motor function". The Journal of Biological Chemistry. 276 (43): 39600–7. doi:10.1074/jbc.M105080200. PMID 11517222.
Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL (Nov 2001). "Myosin VI is a processive motor with a large step size". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13655–9. Bibcode:2001PNAS...9813655R. doi:10.1073/pnas.191512398. PMC 61096. PMID 11707568.
Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (maj 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.
Wu H, Nash JE, Zamorano P, Garner CC (Aug 2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking". The Journal of Biological Chemistry. 277 (34): 30928–34. doi:10.1074/jbc.M203735200. PMID 12050163.
Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER (maj 2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37". American Journal of Human Genetics. 72 (5): 1315–22. doi:10.1086/375122. PMC 1180285. PMID 12687499.
Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.

Vanjski linkovi

Q9UM54

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196586 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033577 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] "UniProt, Q9UM54" (jezik: engleski). Pristupljeno 9. 10. 2021.

[entrez-6] "Entrez Gene: MYO6 myosin VI".

[pmid17353931-7] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid12857860-8] Sennacherib L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.

[pmid11967127-9] Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (maj 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.

[pmid11906161-10] Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.

[pmid26971995-11] He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ (2016). "Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains". Cell Reports. 14 (11): 2683–94. doi:10.1016/j.celrep.2016.01.079. PMC 4805485. PMID 26971995.

[pmid31672988-12] Biancospino M, Buel GR, Niño CA, Maspero E, di Perrotolo RS, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S (2019). "Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension". Nature Communications. 10 (1): 4974. Bibcode:2019NatCo..10.4974B. doi:10.1038/s41467-019-12855-6. PMC 6823378. PMID 31672988.

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