UPK2

UPK2
Identifikatori
Aliasi	UPK2
Vanjski ID-jevi	OMIM: 611558 MGI: 98913 HomoloGene: 4920 GeneCards: UPK2
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	118,958,559 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	44,366,273 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • integral component of plasma membrane; • Egzosom; • apical plasma membrane; • membrana;
Biološki proces	• multicellular organism development; • epithelial cell differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	7379
	22269
	ENSG00000110375
	ENSMUSG00000041523
	O00526
	P38575; Q3SXK0
	NM_006760
	NM_009476
	NP_006751
	NP_033502
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Uroplakin-2 je protein koji je kod ljudi kodiran gengom UPK2.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 184 aminokiselina, а molekulska težina 19.438 Da.^[8].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAPLLPIRTL	PLILILLALL	SPGAADFNIS	SLSGLLSPAL	TESLLVALPP
CHLTGGNATL	MVRRANDSKV	VTSSFVVPPC	RGRRELVSVV	DSGAGFTVTR
LSAYQVTNLV	PGTKFYISYL	VKKGTATESS	REIPMSTLPR	RNMESIGLGM
ARTGGMVVIT	VLLSVAMFLL	VLGFIIALAL	GSRK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110375 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041523 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. PMID 9515818.
^ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
^ "Entrez Gene: UPK2 uroplakin 2".
^ "UniProt, O00526". Pristupljeno 28. 8. 2021.

Dopunska literatura

Lin JH, Wu XR, Kreibich G, Sun TT (1994). "Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane". J. Biol. Chem. 269 (3): 1775–84. PMID 7507484.
Wu XR, Lin JH, Walz T, et al. (1994). "Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins". J. Biol. Chem. 269 (18): 13716–24. PMID 8175808.
Yuasa T, Yoshiki T, Isono T, et al. (1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int. J. Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304. S2CID 43597402.
Li SM, Zhang ZT, Chan S, et al. (1999). "Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder". J. Urol. 162 (3 Pt 1): 931–5. doi:10.1097/00005392-199909010-00093. PMID 10458411.
Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hirata H, Hisatomi H, Kawakita M, et al. (2004). "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction". Oncol. Rep. 10 (4): 963–6. doi:10.3892/or.10.4.963. PMID 12792753.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chen F, Zeng F, Tong Q, et al. (2006). "Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector". J. Huazhong Univ. Sci. Technol. Med. Sci. 25 (2): 188–90, 211. doi:10.1007/BF02873573. PMID 16116969. S2CID 7772680.
Jenkins D, Bitner-Glindzicz M, Malcolm S, et al. (2007). "Mutation analyses of Uroplakin II in children with renal tract malformations". Nephrol. Dial. Transplant. 21 (12): 3415–21. doi:10.1093/ndt/gfl465. PMID 17012268.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110375 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041523 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9515818-5] Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. PMID 9515818.

[pmid9846985-6] Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.

[entrez-7] "Entrez Gene: UPK2 uroplakin 2".

[UniProt-8] "UniProt, O00526". Pristupljeno 28. 8. 2021.

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