CCL16

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski (C-C motivni) ligand 16
Hemokinski (C-C motivni) ligand 16
Identifikatori
Simbol	CCL16
Alt. simboli	SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1
NCBI gen	6360
HGNC	10614
OMIM	601394
RefSeq	NM_004590
UniProt	O15467
Ostali podaci
Lokus	Hrom. 17q11.2
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CCL16
Identifikatori
Aliasi	CCL16
Vanjski ID-jevi	OMIM:601394HomoloGene:48291GeneCards:CCL16
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	35,981,497bp
Ontologija gena
Molekularna funkcija	•cytokine activity; •CCR chemokine receptor binding; •chemoattractant activity; •chemokine activity; •GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	•extracellular region; •Vanćelijsko;
Biološki proces	•monocyte chemotaxis; •chemokine-mediated signaling pathway; •cell-cell signaling; •cellular response to tumor necrosis factor; •neutrophil chemotaxis; •Hemotaksija; •cell communication; •GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; •cellular response to interleukin-1; •GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; •positive regulation of ERK1 and ERK2 cascade; •cellular response to interferon-gamma; •lymphocyte chemotaxis; •inflammatory response; •positive chemotaxis; •regulation of signaling receptor activity; •G protein-coupled receptor signaling pathway; •eosinophil chemotaxis;
	Izvori:Amigo/QuickGO
Ortolozi
	6360
	n/a
	ENSG00000275152; ENSG00000275095
	n/a
	O15467
	n/a
	NM_004590
	n/a
	NP_004581
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 16(CCL16) jest malicitokinkoji pripada porodici CChemokinai poznat je pod nekolikopseudonima,uključujući hemokine koji eksprimirajetra(LEC) i monotaktin-1 (MTN-1). Ovaj hemokin se ekspimira u jetri,timusuislezenii hemoatraktivan je zamonociteilimfocite.^[3]Ćelijska ekspresija CCL16 može se snažno inducirati u monocitima pomoćuInterleukinIL-10,IFN-γi bakterijsilipopolisaharid.Njegovgennalazi se nahromosomu 17,kod ljudi, među skupinom ostalih CC-hemokina.^[4]CCL16 izaziva učinke na ćelije interakcijom sa hemokinskim receptorima na površini ćelije, kao što suCCR1,CCR2,CCR5iCCR8.^[5]^[6]

C-C motiv hemokinskih liganada 16 pronađen je u visokim nivoima u ljudskoj krvnoj plazmi.^[7] CCL16 može biti koristan za promet eozinofila. Utvrđeno je da ovajligandima funkcionalni afinitet za H4 receptore koji se eksprimiraju ueozinofilimaimastocitima.^[7] Pokazano je da ovaj hemokin suzbija brzu proliferaciju mijeloidnih progenitornih ćelija.^[8]

Aminokiselinska sekvenca

Dužinapolipeptidnoglanca je 120aminokiselina,amolekulska težina13.600Da.^[9].

10	20	30	40	50
MKVSEAALSL	LVLILIITSA	SRSQPKVPEW	VNTPSTCCLK	YYEKVLPRRL
VVGYRKALNC	HLPAIIFVTK	RNREVCTNPN	DDWVQEYIKD	PNLPLLPTRN
LSTVKIITAK	NGQPQLLNSQ

Simboli

C:Cistein
D:Asparaginska kiselina
E:Glutaminska kiselina
F:Fenilalanin
G:Glicin
H:Histidin
I:Izoleucin
K:Lizin
L:Leucin
M:Metionin
N:Asparagin
P:Prolin
Q:Glutamin
R:Arginin
S:Serin
T:Treonin
V:Valin
W:Triptofan
Y:Tirozin

Reference

^^a ^b ^cENSG00000275095 GRCh38: Ensembl release 89: ENSG00000275152, ENSG00000275095-Ensembl,maj 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS (juni 1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity".Biochemical and Biophysical Research Communications.247(2): 217–22.doi:10.1006/bbrc.1998.8762.PMID 9642106.
^Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O (mart 1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES".Journal of Interferon & Cytokine Research.19(3): 227–34.doi:10.1089/107999099314153.PMID 10213461.
^Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O (august 2001)."Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes".International Immunology.13(8): 1021–9.doi:10.1093/intimm/13.8.1021.PMID 11470772.
^Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (august 2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8".Blood.96(3): 840–5.doi:10.1182/blood.V96.3.840.PMID 10910894.
^^a ^bNakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O (august 2004)."Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor".Journal of Immunology.173(3): 2078–83.doi:10.4049/jimmunol.173.3.2078.PMID 15265943.
^"CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"UniProt, O15467".Pristupljeno 28. 6. 2021.

[refGRCh38Ensembl-1] ENSG00000275095 GRCh38: Ensembl release 89: ENSG00000275152, ENSG00000275095-Ensembl,maj 2017

[2] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[Youn_1998-3] Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS (juni 1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity".Biochemical and Biophysical Research Communications.247(2): 217–22.doi:10.1006/bbrc.1998.8762.PMID 9642106.

[Nomiyama_1991-4] Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O (mart 1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES".Journal of Interferon & Cytokine Research.19(3): 227–34.doi:10.1089/107999099314153.PMID 10213461.

[Nomiyama_2001-5] Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O (august 2001)."Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes".International Immunology.13(8): 1021–9.doi:10.1093/intimm/13.8.1021.PMID 11470772.

[Howard_2000-6] Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (august 2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8".Blood.96(3): 840–5.doi:10.1182/blood.V96.3.840.PMID 10910894.

[Nakayama_2004-7] Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O (august 2004)."Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor".Journal of Immunology.173(3): 2078–83.doi:10.4049/jimmunol.173.3.2078.PMID 15265943.

[entrez-8] "CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene".National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-9] "UniProt, O15467".Pristupljeno 28. 6. 2021.

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