CTLA4

CTLA4
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 3OSK,1AH1,1H6E,1I85,1I8L,2X44,3BX7
Dynodwyr
Cyfenwau	CTLA4,ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
Dynodwyr allanol	OMIM:123890HomoloGene:3820GeneCards:CTLA4
PatrwmRNApattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •GO:0001948, GO:0016582 protein binding Cydrannau o'r gell •perinuclear region of cytoplasm •integral component of membrane •clathrin-coated endocytic vesicle •Cellbilen •Golgi apparatus •bilen •external side of plasma membrane •protein complex involved in cell adhesion •integral component of plasma membrane Prosesau biolegol •B cell receptor signaling pathway •T cell costimulation •negative regulation of B cell proliferation •adaptive immune response •negative regulation of regulatory T cell differentiation •GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response •cellular response to DNA damage stimulus •immune system process •positive regulation of apoptotic process •negative regulation of immune response •negative regulation of T cell proliferation •regulation of regulatory T cell differentiation •regulation of T cell proliferation •T cell receptor signaling pathway Sources:Amigo/QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1493	n/a
Ensembl	ENSG00000163599	n/a
UniProt	P16410	n/a
RefSeq (mRNA)	NM_001037631 NM_005214	n/a
RefSeq (protein)	NP_001032720 NP_005205	n/a
Lleoliad (UCSC)	n/a	n/a
PubMedsearch		n/a
Wicidata
Gweld/Golygu Bod dynol

Proteinsy'n cael ei godio yn ycorff dynolgan y genynCTLA4ywCTLA4a elwir hefyd ynCytotoxic T-lymphocyte associated protein 4(Saesneg). Segment oDNAyw'rgenyn,sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTLA4.

• CD
• GSE
• GRD4
• ALPS5
• CD152
• CTLA-4
• IDDM12
• CELIAC3

Llyfryddiaeth

• "CD25-expressing Th17 cells mediate CD8+ T cell suppression in CTLA-4 dependent mechanisms in pancreatic ductal adenocarcinoma.".Exp Cell Res.2017.PMID28942020.
• "CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases.".Cancer Immunol Immunother.2017.PMID28707078.
• "CTLA-4 +49 G/A Polymorphism Confers Autoimmune Disease Risk: An Updated Meta-Analysis.".Genet Test Mol Biomarkers.2017.PMID28384040.
• "CTLA-4 gene polymorphisms associate with efficacy of postoperative radioiodine-131 for differentiated thyroid carcinoma.".Future Oncol.2017.PMID28326838.
• "[Association between CTLA-4 gene polymorphism and Henoch-Schönlein purpura in children].".Zhongguo Dang Dai Er Ke Za Zhi.2017.PMID28302200.