EPB41

EPB41
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 1GG3,2RQ1,3QIJ
Dynodwyr
Cyfenwau	EPB41,erythrocyte membrane protein band 4.1, 4.1R, EL1, HE
Dynodwyr allanol	OMIM:130500HomoloGene:44324GeneCards:EPB41
PatrwmRNApattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •spectrin binding •structural molecule activity •calmodulin binding •cytoskeletal protein binding •1-phosphatidylinositol binding •structural constituent of cytoskeleton •GO:0001948, GO:0016582 protein binding •actin binding •protein C-terminus binding •protein N-terminus binding •phosphoprotein binding Cydrannau o'r gell •bilen •cortical cytoskeleton •cell junction •cell cortex •spectrin-associated cytoskeleton •Cytosgerbwd •cnewyllyn cell •cytoplasm •cytosol •cytoplasmic side of plasma membrane •GO:0097483, GO:0097481 postsynaptic density •Cellbilen •cell cortex region •GO:0009327 protein-containing complex •basolateral plasma membrane Prosesau biolegol •positive regulation of protein binding •GO:0033109 cortical actin cytoskeleton organization •actin cytoskeleton organization •actomyosin structure organization •regulation of cell shape •positive regulation of protein localization to cell cortex •cell cycle •Cellraniad •GO:0034622 protein-containing complex assembly •regulation of calcium ion transport •regulation of intestinal absorption Sources:Amigo/QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2035	n/a
Ensembl	ENSG00000159023	n/a
UniProt	P11171	n/a
RefSeq (mRNA)	NM_001166005 NM_001166006 NM_001166007 NM_004437 NM_203342 NM_203343 NM_001376013 NM_001376014 NM_001376015 NM_001376016 NM_001376017 NM_001376018 NM_001376019 NM_001376020 NM_001376021 NM_001376022 NM_001376023 NM_001376024 NM_001376025 NM_001376026 NM_001376027 NM_001376028	n/a
RefSeq (protein)	NP_001159477 NP_001159478 NP_001159479 NP_004428 NP_976217 NP_976218 NP_001362942 NP_001362943 NP_001362944 NP_001362945 NP_001362946 NP_001362947 NP_001362948 NP_001362949 NP_001362950 NP_001362951 NP_001362952 NP_001362953 NP_001362954 NP_001362955 NP_001362956 NP_001362957	n/a
Lleoliad (UCSC)	n/a	n/a
PubMedsearch		n/a
Wicidata
Gweld/Golygu Bod dynol

Proteinsy'n cael ei godio yn ycorff dynolgan y genynEPB41ywEPB41a elwir hefyd ynErythrocyte membrane protein band 4.1(Saesneg). Segment oDNAyw'rgenyn,sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p35.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPB41.

• HE
• EL1
• 4.1R

Llyfryddiaeth

• "Alternative polyadenylation in a family of paralogous EPB41 genes generates protein 4.1 diversity.".RNA Biol.2017.PMID27981895.
• "Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk.".Am J Hum Genet.2016.PMID27453575.
• "Comprehensive characterization of protein 4.1 expression in epithelium of large intestine.".Histochem Cell Biol.2014.PMID24912669.
• "Structural stabilization of protein 4.1R FERM domain upon binding to apo-calmodulin: novel insights into the biological significance of the calcium-independent binding of calmodulin to protein 4.1R.".Biochem J.2011.PMID21848512.
• "Nonsense-mediated mRNA decay (NMD) blockage promotes nonsense mRNA stabilization in protein 4.1R deficient cells carrying the 4.1R Coimbra variant of hereditary elliptocytosis.".Blood Cells Mol Dis.2010.PMID20863723.