NFKB1

NFKB1
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 1MDI,1MDJ,1MDK,1NFI,1SVC,2DBF,2O61,3GUT
Dynodwyr
Cyfenwau	NFKB1,EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, CVID12, nuclear factor kappa B subunit 1, NF-kappa-B1, NF-kB, NF-kappabeta
Dynodwyr allanol	OMIM:164011HomoloGene:2971GeneCards:NFKB1
PatrwmRNApattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity •RNA polymerase II transcription regulatory region sequence-specific DNA binding •transcription factor binding •GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific •GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific •GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding •protein homodimerization activity •chromatin binding •GO:0001948, GO:0016582 protein binding •DNA binding •sequence-specific DNA binding •actinin binding •identical protein binding •GO:0000975 transcription cis-regulatory region binding •protein heterodimerization activity •GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell •cytoplasm •mitocondria •cnewyllyn cell •I-kappaB/NF-kappaB complex •nucleoplasm •extracellular region •cytosol •secretory granule lumen •specific granule lumen Prosesau biolegol •cellular response to interleukin-6 •positive regulation of canonical Wnt signaling pathway •GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II •transcription by RNA polymerase II •negative regulation of vitamin D biosynthetic process •Fc-epsilon receptor signaling pathway •cellular response to mechanical stimulus •NIK/NF-kappaB signaling •stress-activated MAPK cascade •negative regulation of inflammatory response •GO:0097285 apoptotic process •response to muscle stretch •GO:0009373 regulation of transcription, DNA-templated •stimulatory C-type lectin receptor signaling pathway •transcription, DNA-templated •GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated •negative regulation of calcidiol 1-monooxygenase activity •positive regulation of hyaluronan biosynthetic process •membrane protein intracellular domain proteolysis •inflammatory response •I-kappaB kinase/NF-kappaB signaling •positive regulation of miRNA metabolic process •cellular response to nicotine •GO:1901227 negative regulation of transcription by RNA polymerase II •positive regulation of macrophage derived foam cell differentiation •positive regulation of NF-kappaB transcription factor activity •negative regulation of cholesterol transport •GO:0045996 negative regulation of transcription, DNA-templated •GO:0032697 negative regulation of cytokine production •positive regulation of lipid storage •cellular response to dsRNA •T cell receptor signaling pathway •positive regulation of type I interferon production •GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II •GO:0072468 signal transduction •cellular response to lipopolysaccharide •cellular response to interleukin-1 •innate immune response •negative regulation of apoptotic process •negative regulation of gene expression •neutrophil degranulation •cellular response to tumor necrosis factor •cellular response to angiotensin •interleukin-1-mediated signaling pathway Sources:Amigo/QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4790	n/a
Ensembl	ENSG00000109320	n/a
UniProt	P19838	n/a
RefSeq (mRNA)	NM_001165412 NM_003998 NM_001319226 NM_001382625 NM_001382626 NM_001382627 NM_001382628	n/a
RefSeq (protein)	NP_001158884 NP_001306155 NP_003989 NP_001369554 NP_001369555 NP_001369556 NP_001369557 NP_001158884.1 NP_001306155.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMedsearch		n/a
Wicidata
Gweld/Golygu Bod dynol

Proteinsy'n cael ei godio yn ycorff dynolgan y genynNFKB1ywNFKB1a elwir hefyd ynNuclear factor NF-kappa-B p105 subunit a Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (P105), isoform CRA_b(Saesneg). Segment oDNAyw'rgenyn,sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q24.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFKB1.

• p50
• KBF1
• p105
• EBP-1
• CVID12
• NF-kB1
• NFKB-p50
• NFkappaB
• NF-kappaB
• NFKB-p105
• NF-kappa-B

Llyfryddiaeth

• "Genes directly regulated by NF-κB in human hepatocellular carcinoma HepG2.".Int J Biochem Cell Biol.2017.PMID28579529.
• "EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells.".PLoS One.2017.PMID28346502.
• "Elevated NF-κB signaling in Asherman syndrome patients and animal models.".Oncotarget.2017.PMID28148903.
• "Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.".J Allergy Clin Immunol.2017.PMID28115215.
• "Mutant DD genotype of NFKB1 gene is associated with the susceptibility and severity of coronary artery disease.".J Mol Cell Cardiol.2017.PMID28088561.