Alpiropride(INNTooltip International Nonproprietary Name;brand nameRevistel,Rivistel,orRivestel) is adopamineD2receptorantagonistof thebenzamidegroup related tosulpiride.[1][2][3][4][5]It is described as anantihypertensive agentand has been marketed for use as anantimigrainemedicationinPortugal.[1][4][2]The drug was first described by 1980[1]and was introduced for medical use by 1989.[4]It remained marketed in Portugal as late as 2000.[2]

Alpiropride
Clinical data
Trade namesRevistel, Rivistel, or Rivestel
Other namesIristel; RIV-2093; RIV2093; RIV 2093; Riv 2093; Riv-2093; Riv2093
Drug classDopamineD2receptorantagonist;Antihypertensive agent;Antimigraine agent
Identifiers
  • 4-amino-2-methoxy-5-(methylsulfamoyl)-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]benzamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.072.585Edit this at Wikidata
Chemical and physical data
FormulaC17H26N4O4S
Molar mass382.48g·mol−1
3D model (JSmol)
  • CNS(=O)(=O)C1=C(C=C(C(=C1)C(=O)NCC2CCCN2CC=C)OC)N
  • InChI=1S/C17H26N4O4S/c1-4-7-21-8-5-6-12(21)11-20-17(22)13-9-16(26(23,24)19-2)14(18)10-15(13)25-3/h4,9-10,12,19H,1,5-8,11,18H2,2-3H3,(H,20,22)
  • Key:QRQMZZNDJGHPHZ-UHFFFAOYSA-N

References

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  1. ^abcElks J (2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies.Springer US. p. 33.ISBN978-1-4757-2085-3.Retrieved24 October2024.
  2. ^abcSchweizerischer Apotheker-Verein (2000).Index Nominum 2000: International Drug Directory.Medpharm Scientific Publishers. p. 31.ISBN978-3-88763-075-1.Retrieved24 October2024.
  3. ^Milne GW (2018).Drugs: Synonyms and Properties.Routledge Revivals. Taylor & Francis. p. 358.ISBN978-1-351-78990-5.Retrieved24 October2024.
  4. ^abcOng HH, Allen RC (1989). "Chapter 31. To Market, To Market -1988".Annual Reports in Medicinal Chemistry.Vol. 24. Elsevier. pp. 295–315.doi:10.1016/s0065-7743(08)60553-9.ISBN978-0-12-040524-4.ISSN0065-7743.
  5. ^Ren S, Lien LL, Lien EJ (August 1997)."Molecular modeling and structural analysis of benzamide derivatives with and without extrapyramidal syndrome side effects.".Current Medicinal Chemistry.Vol. 4. Bentham Science Publishers. pp. 271-278 (275).Retrieved24 October2024.