GPR75

GPR75
Identifiers
Aliases	GPR75,GPRchr2, WI31133, G protein-coupled receptor 75
External IDs	OMIM:606704;MGI:2441843;HomoloGene:4945;GeneCards:GPR75;OMA:GPR75 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	53,859,967bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	30,843,729bp
RNA expressionpattern
	Top expressed in
	testicle; ; ventricular zone; ; islet of Langerhans; ; prefrontal cortex; ; internal globus pallidus; ; caudate nucleus; ; nucleus accumbens; ; Amygdala; ; putamen; ; cingulate gyrus;
	Top expressed in
	lumbar spinal ganglion; ; visual cortex; ; cerebellar cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; embryo; ; neural layer of retina; ; embryo; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-C chemokine receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	chemokine-mediated signaling pathway; regulation of neuron death; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo/QuickGO
Orthologs
	10936
	237716
	ENSG00000119737
	ENSMUSG00000043999
	O95800
	Q6X632
	NM_006794
	NM_175490
	NP_006785
	NP_780699
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 75is aproteinthat in humans is encoded by theGPR75gene.^[5]^[6]

Function

GPR75 is a member of theG protein-coupled receptorfamily. GPRs are cell surface receptors that activateguanine-nucleotide binding proteinsupon the binding of a ligand.^[6]

GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokineCCL5(RANTES) has been shown to stimulate calcium mobilization andinositol triphosphateformation in GPR75-transfected cells.^[7]

A 2021 study reported that people with protein-truncating variants of GPR75 were associated with 5.3kg lower body weight and 54% lower odds for obesity. GPR75 knock-out mice showed resistance to weight gain under high-fat diet.^[8]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000119737–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000043999–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tarttelin EE, Kirschner LS, Bellingham J, Baffi J, Taymans SE, Gregory-Evans K, Csaky K, Stratakis CA, Gregory-Evans CY (June 1999). "Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16".Biochemical and Biophysical Research Communications.260(1): 174–80.doi:10.1006/bbrc.1999.0753.PMID 10381362.
^^a ^b"Entrez Gene: GPR75 G protein-coupled receptor 75".
^Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006)."RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75".British Journal of Pharmacology.149(5): 490–7.doi:10.1038/sj.bjp.0706909.PMC2014681.PMID 17001303.
^Akbari P, Gilani A, Sosina O, et al. (2 July 2021)."Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity".Science.373(6550).doi:10.1126/science.abf8683.PMC10275396.PMID 34210852.S2CID 235699731.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119737–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043999–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10381362-5] Tarttelin EE, Kirschner LS, Bellingham J, Baffi J, Taymans SE, Gregory-Evans K, Csaky K, Stratakis CA, Gregory-Evans CY (June 1999). "Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16".Biochemical and Biophysical Research Communications.260(1): 174–80.doi:10.1006/bbrc.1999.0753.PMID 10381362.

[entrez-6] "Entrez Gene: GPR75 G protein-coupled receptor 75".

[7] Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006)."RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75".British Journal of Pharmacology.149(5): 490–7.doi:10.1038/sj.bjp.0706909.PMC2014681.PMID 17001303.

[8] Akbari P, Gilani A, Sosina O, et al. (2 July 2021)."Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity".Science.373(6550).doi:10.1126/science.abf8683.PMC10275396.PMID 34210852.S2CID 235699731.

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