Phenindamine

Phenindamine(Nolahist,Thephorin) is anantihistamineandanticholinergicclosely related tocyproheptadine.It was developed byHoffman-La Rochein the late 1940s.It is used to treat symptoms of thecommon coldandallergies,such as sneezing, itching, rashes, andhives.Its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a number of countries;William S. Burroughs' bookJunkiementions this technique. Like many other first-generation antihistamines, phenindamine has useful potentiating effects on many narcotic analgesics and is even more useful with those opioids which release histamine when in the body.

Phenindamine

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	R06AX04(WHO)
Legal status
Legal status	US:OTC
Identifiers
IUPAC name 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine
CAS Number	82-88-2Y
PubChemCID	11291
DrugBank	DB01619N
ChemSpider	10817N
UNII	772BQ8KSST
KEGG	D08353Y
ChEMBL	ChEMBL278398N
CompTox Dashboard(EPA)	DTXSID0023452
ECHA InfoCard	100.001.313
Chemical and physical data
Formula	C19H19N
Molar mass	261.368g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C1)CCC2=C1C(C3=C2C=CC=C3)C4=CC=CC=C4
InChI InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3N Key:ISFHAYSTHMVOJR-UHFFFAOYSA-NN
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Nolahist was originally manufactured in the US by Carnrick Laboratories, and later by Amarin Pharmaceuticals. When that company ceased its American operations, its product line was acquired byValeant,but they declined to resume manufacturing Nolahist. The last produced lot bore an expiration date of 10/2005, and the product is no longer available.

Phenindamine does exhibitoptical isomerismas do other chemicals of its general type ranging frompethidineandalphaprodinetocyproheptadine.

See also

• Cyproheptadine