17α-Bromoprogesterone(17α-BP) is aprogestinwhich was first described in 1957 and was never marketed.[1][2][3][4]It is about twice aspotentasprogesteronein terms ofprogestogenicactivity in animalbioassays.[1]17α-BP is aparent compoundofhaloprogesterone(6α-fluoro-17α-bromoprogesterone) and6α-methyl-17α-bromoprogesterone.[5]
Clinical data | |
---|---|
Other names | 17α-BP; 17α-Bromopregn-4-ene-3,20-dione |
Drug class | Progestogen;Progestin |
Identifiers | |
| |
CAS Number | |
PubChemCID | |
UNII | |
Chemical and physical data | |
Formula | C21H29BrO2 |
Molar mass | 393.365g·mol−1 |
3D model (JSmol) | |
| |
|
See also
editReferences
edit- ^abEngel CR, Jahnke H (November 1957). "Steroids and related products. X. 17 alpha-Bromoprogesterone, a new potent gestogen".Canadian Journal of Biochemistry and Physiology.35(11): 1047–1055.doi:10.1139/o57-120.PMID13479803.
- ^Seeley DH, Wang WY, Salhanick HA (November 1982)."Molecular interactions of progesterone analogues with rabbit uterine cytoplasmic receptor".The Journal of Biological Chemistry.257(22): 13359–13366.doi:10.1016/S0021-9258(18)33456-2.PMID7142152.
- ^Bohl M, Simon Z, Vlad A, Kaufmann G, Ponsold K (1987)."MTD calculations on quantitative structure-activity relationships of steroids binding to the progesterone receptor".Zeitschrift für Naturforschung C.42(7–8): 935–940.doi:10.1515/znc-1987-7-834.PMID2961153.S2CID22962904.
- ^Simon Z, Bohl M (1992). "Structure-activity Relations in Gestagenic Steroids by the MTD Method. The Case of Hard Molecules and Soft Receptors".Quantitative Structure-Activity Relationships.11(1): 23–28.doi:10.1002/qsar.19920110104.ISSN0931-8771.
- ^Elks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies.Springer. pp. 179, 620.ISBN978-1-4757-2085-3.