Adrian Robert Kraineris a Uruguayan-American biochemist andmolecular geneticist[2]known for his research intoRNA gene-splicing.He helped create a drug for patients with spinal muscular atrophy.[3]Krainer holds the St. Giles Foundation Professorship atCold Spring Harbor LaboratoryinLaurel Hollow, New York.
Adrian Krainer | |
|---|---|
 Krainer in 2018 | |
| Born | Adrian Robert Krainer Montevideo,Uruguay |
| Alma mater | Columbia University(BA) Harvard University(PhD) |
| Known for | RNA splicing |
| Spouse | Kate Krainer |
| Children | 3 |
| Awards | |
| Scientific career | |
| Institutions | Cold Spring Harbor Laboratory Stony Brook University |
| Thesis | Nuclear pre-mRNA splicing in vitro(1986) |
| Notable students | Ewan Birney |
| Website | www |
Early life and education
editKrainer was born inMontevideo,Uruguay to a Jewish family ofHungarianandRomaniandescent. He has one older brother, who is achemical engineer.His father did forced labor for two years in a Romanian labor camp (Ferma Alba) duringWorld War II.After the war, his father's original surname, Kreiner changed to Krainer due to a clerical error when he was a refugee inItaly.His parents owned a small leather business in Montevideo. Krainer attended a private bilingual French-Spanish elementary school. He later attended a public school for two years before completing his pre-college education with four years at a private Spanish-Hebrew school. Krainer lived through political unrest during his teenage years, including urban guerrilla and military dictatorship. Krainer received a full scholarship fromColumbia Universityand completed aBachelor of Artsdegree inBiochemistryin 1981.[4]He graduatedcum laudeandPhi Beta Kappa.In 1986, he earned aDoctor of Philosophydegree in biochemistry fromHarvard University.[5]
Career and research
editFrom 1986 to 1989, Krainer conductedpostdoctoral researchas the first Cold Spring Harbor Fellow at theCold Spring Harbor Laboratory.Krainer worked as an assistant professor from 1989 to 1990, Associate Professor from 1990 to 1994, and Professor since 1994. Krainer is a faculty member of the graduate programs in Genetics, Molecular and Cellular Biology, and Molecular Genetics and Microbiology atState University of New York, Stony Brook.[5]Krainer holds the St. Giles Foundation Professorship atCold Spring Harbor Laboratory.[6]His former students includeEwan Birney.[7][8]Krainer is a co-founder and Director of Stoke Therapeutics, based in Bedford, MA.
Awards and honors
editIn 2019 he was awarded aBreakthrough Prize in Life Sciencesfor his contributions to the understanding of the RNA gene-splicing process and, in collaboration with fellow Prize Laureate Dr. Frank Bennet ofIonis Pharmaceuticals,the development of medical interventions that target the RNA-splicing process, includingSpinraza,which is the first treatment for the genetic disorderSpinal Muscular Atrophy.[9][10]In 2021 Krainer received theWolf Prize in Medicine.[11]In 2024 he was awarded theAlbany Medical Center Prizejointly withHoward Y. ChangandLynne E. Maquat.[12]
Other honors include:
- Pew Scholarin the Biomedical Sciences (1992–96);
- National Institute of General Medical Sciences MERIT Award (2012-2022);
- New York Intellectual Property Law Association Inventor of the Year Award (2017);
- FE Bennett Award of the American Neurological Association (2017);
- RNA Society Lifetime Achievement Award (2019);
- Ross Prize in Molecular Medicine (2020);
- Gregor Johann Mendel Medal for Outstanding Achievements in Science (2020), Brno, Czech Republic;
- Fellow of theAmerican Academy of Arts & Sciences(2016);
- Fellow of theNational Academy of Inventors(2018);
- Member of theNational Academy of Medicine(2019);
- Member of theNational Academy of Sciences(2020)[1]
Personal life
editKrainer's father and maternal grandparents were Holocaust refugees.[9]He has three children, Emily, Andrew, and Brian.[9][5]His wife, Kate Krainer, is a plant geneticist.[13][14]
References
edit- ^ab"2020 NAS Election".nasonline.org.RetrievedMay 1,2020.
- ^Adrian Krainerpublications fromEurope PubMed Central
- ^Adrian Krainer, Václav Hradilek, Boženka Hradilková - Hyde Park Civilizace | Česká televize(in Czech),retrievedAugust 10,2023
- ^"AitN: November 12, 2018".Columbia College Today.November 12, 2018.RetrievedDecember 21,2020.
- ^abcMaestrejuan, Andrea R. (September 9, 1997)."ADRIAN R. KRAINER"(PDF).sciencehistory.org.Chemical Heritage Foundation.RetrievedOctober 16,2018.
- ^"Adrian R. Krainer - Cold Spring Harbor Laboratory".cshl.edu.Cold Spring Harbor Laboratory.RetrievedOctober 16,2018.
- ^Al-Khalili, Jim(2013)."The Life Scientific, Ewan Birney".bbc.co.uk.BBC.
- ^Birney, E.;Kumar, S.; Krainer, A. (1992)."A putative homolog of U2AF65 in S. Cerevisiae".Nucleic Acids Research.20(17): 4663.doi:10.1093/nar/20.17.4663.PMC334203.PMID1408772.
- ^abc"Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Adrian R. Krainer".breakthroughprize.org.RetrievedAugust 8,2020.
- ^"Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – C. Frank Bennett".breakthroughprize.org.RetrievedAugust 8,2020.
- ^Wolf Prize in Medicine 2021
- ^Albany Medical Center Prize 2024
- ^s.r.o, Via Aurea."Adrian Krainer, the Scientist Who Brought Hope to Thousands of Children, Shared his Experience With Students".ceitec.eu.RetrievedAugust 8,2020.
- ^s.r.o, Via Aurea."Life after PhD with Adrian and Kate Krainer".ceitec.eu.RetrievedAugust 8,2020.