Afloqualone

Afloqualone
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	none;
Legal status
Legal status	US:Unscheduled;
Identifiers
	IUPAC name 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one;
CAS Number	56287-74-2;
PubChemCID	2040;
ChemSpider	1960;
UNII	CO4U2C8ORZ;
KEGG	D01638;
ChEMBL	ChEMBL2105918;
CompTox Dashboard(EPA)	DTXSID5022562;
Chemical and physical data
Formula	C16H14FN3O
Molar mass	283.306g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1C2=CC(N)=CC=C2N=C(CF)N1C3=CC=CC=C3C;
	InChI InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3; Key:VDOSWXIDETXFET-UHFFFAOYSA-N;
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Afloqualone(Arofuto) is aquinazolinonefamilyGABAergic drugand is an analogue ofmethaqualonedeveloped in the 1970s by a team at Tanabe Seiyaku.^[1]It hassedativeandmuscle-relaxanteffects resulting from its agonist activity at the β subtype of theGABA_areceptor^[2]and has had some clinical use, although it causesphotosensitizationas a side-effect that can cause skin problems such asdermatitis.^[3]