Wikipedia

Ageusia

Ageusia(from negative prefixa-andAncient Greekγεῦσιςgeûsis 'taste') is the loss oftastefunctions of thetongue,particularly the inability to detect sweetness, sourness, bitterness, saltiness, andumami(meaning 'savory taste'). It is sometimes confused withanosmia– a loss of thesenseofsmell.True ageusia is relatively rare compared tohypogeusia– a partial loss of taste – anddysgeusia– a distortion or alteration of taste.[1][2]

Ageusia
Pronunciation
SpecialtyNeurology

Even though ageusia is considered relatively rare it can impact individuals of any age or demographic.[3]There has been an increase in reported cases of ageusia, due to the COVID-19 pandemic making ageusia more commonly diagnosed than before.[4]

Symptoms

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The complete loss of taste.[5]

Causes

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Ageusia can arise from various factors:[5][2][6][4][7]

  • Issues with the water-soluble molecules responsible for taste, causing oral dryness or damage to taste buds.[5]
  • Radiation therapytreatments.[5]
  • Facial nerve damage due to surgery.[7]
  • Head traumas, traumas to middle ear or jaw.[4][5]
  • Sinusitis,strep throat, salivary gland infections, common cold,influenza,andCOVID-19.[5][6][4]
  • Bell's palsyor dental procedures like a molar extraction andtonsillectomy.[5]
  • Epilepsy,tumors, stroke, ormultiple sclerosis.[5][4]
  • Diseases that can affect the autonomic nervous system, like diabetes.[5]
  • Some medications, including muscle relaxants, chemotherapy medication, anti-fungal, chemical compounds found in anti-depressants, anti-seizure medications, and blood pressure medications.[5]
  • Sialadenitis,gingivitis, oral infections, orglossodynia(burning mouth syndrome (BMS)).[5][2]

Ageusia resulting from a significant head injury is relatively uncommon, affecting only around 1% of individuals with this type of injury.[5]

COVID-19

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Main article:Symptoms of COVID-19 § Loss of taste and chemesthesis

Ageusia can be an indication of a COVID-19 infection.[7]Ageusia and anosmia are among the prominent symptoms commonly associated with COVID-19, with symptoms that could last up to 4 weeks.[3][8]However, it is noteworthy that ageusia may manifest differently from anosmia, as anosmia primarily affects the olfactory system versus ageusia primarily affecting the gustatory receptors.[3]As a result, emerging research indicates that the variousvariantsof COVID-19 might be associated with differences in the severity of ageusia experienced by patients, as well as the severity of other taste and smell disorders. Implying that certain strains of the virus may have differing impacts on the sensory functions of affected individuals.[9]

Studies investigating the prevalence of taste disorders stemming from the COVID-19 pandemic indicate that a wide range of individuals were impacted, with some experiencing these issues more severely than others:[10]

Patients[10] %
European Patients 55.2%
North American Patients 61.0%
Asian Patients 27.1%
South American Patients 29.5%
Australian Patients 25.0%

Patients with ageusia observed in 28.0% of patients,hypogeusiain about 33.5%, anddysgeusiain about 41.3% of patients.[10]

In April 2020, 88% of a series of over 400COVID-19disease patients in Europe were reported to report gustatory dysfunction (86% reportedolfactorydysfunction).[11]Additionally, in South Korea, out of approximately 2,000 recorded cases of individuals with ageusia related infection from COVID-19, only 30% exhibited ageusia.[8]

The duration of ageusia recovery can vary significantly depending on cause of infection.[4]In a COVID-19-related infection, the recovery timeline for ageusia can vary among individuals, influenced by factors such as variants or strains of the virus, individual immune responses, demographic characteristics, and other factors.[4][2][3]

Proposed mechanisms of infection

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Recent research has hinted at a connection between the distribution of taste cells andACE2receptors in ageusia. Higher amounts of the receptors suggests an easy route for a COVID-19 infection with a possible outcome of ageusia.[9]

Ageusia could also possibly occur due to changes in the abundance or lack of saliva that can eventually cause damage to the cells on the tongue's surface.[12]

Saliva and taste perception

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Saliva is essential in taste sensation and perception. Studies have indicated that saliva plays a critical role in detecting a COVID-19 infection, and ageusia can serve as an indication of an infection that is affecting thesalivary glands.[8]

However, there is still insufficient research to fully clarify the full effects of ageusia, COVID-19, and their potential impacts on saliva and 'salivary flow rate.'[8]

Zinc deficiency

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In cases of zinc deficiency, a shortage of zinc-binding proteins that help with the growth and development of taste buds, could result in taste bud issues associated with ageusia, hypogeusia, andhyposalivation.[8]

Low levels ofcyclic adenosine monophosphate(cAMP) andcyclic guanosine monophosphate(cGMP), which help with the growth of taste buds, in saliva have also been linked to ageusia.[8]

Diagnosis

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Ageusia is usually diagnosed by anotolaryngologist,also known as an ear nose and throat doctor(ENT).[4]These individuals can evaluate a patient's loss of taste among other things. To do this, a specialist will look into any other factors that could be causing ageusia, such as examining the head, nose, ears, and mouth. As well as imaging of the head and neck, to help further identify or eliminate the presence of tumors, focal lesions, or any type of injury that could possibly be affecting any taste-related networks.[5][13][14]An otolaryngologist can also conduct a series of tests to assess the severity of ageusia, which includes identifying specific tastes that the patient can sense or recognize.[13][14]

An example of a test used by researchers and doctors iselectrogustometry.This test involves applying mild electric currents to specific tongue areas, to assess taste sensitivity in patients exhibiting ageusia and its symptoms.[5]

Another test that can be used to detect the severity of an individuals ageusia is an 'suprathreshold taste test,' also known as a edible strip taste test. The edible strip is placed on the individuals tongue and it contains various flavors for the patient to be able to detect, or not able to detect.[7]

Treatment

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Treatment for ageusia varies depending on its cause, whether it stems from certain illnesses, medications, traumatic injuries or other causes.

If ageusia is triggered by a medication prescribed to a patient, discontinuing the medication under the guidance of a healthcare professional may alleviate the symptoms. Switching to an alternative medication can also help resolve the issue.[7]In cases where ageusia is associated with an underlying illness or trauma, some medications can also help alleviate symptoms. Some of these medications include,antihistamines,decongestants, and antibiotics.[5][4]

Complications

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People experiencing ageusia can endure daily discomfort, which frequently diminishes their enjoyment of eating. This discomfort can cause many individuals affected by taste disorders with feelings of:[5]

  • Isolation in individuals experiences[5]
  • Feelings of depression[5]
  • Social withdrawal[5]
  • Unhealthy eating habits[5]

Such eating habits may involve either insufficient food intake or excessive consumption of sour or sweet foods. This dietary pattern could pose risks, particularly for individuals with diabetes.[5][7]

Ageusia and Diabetes

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Diabeteshas been shown to sometimes lead to ageusia, often starting with fluctuations inglucoselevels. When blood sugar levels fluctuate, it can disrupt the taste buds, making it difficult to detect flavors. But not everyone with diabetes will experience this. The severity of an individuals ageusia or other taste dysfunction can differ from person to person.[5][7]

References

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  1. ^"Taste Disorders".Massachusetts Eye and Ear Infirmary.Retrieved30 November2018.
  2. ^abcdHummel T, Landis BN, Hüttenbrink KB (2011)."Smell and taste disorders".GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery.10:Doc04.doi:10.3205/cto000077.PMC3341581.PMID22558054.
  3. ^abcdVaira LA, Salzano G, Deiana G, De Riu G (July 2020)."Anosmia and Ageusia: Common Findings in COVID-19 Patients".The Laryngoscope.130(7): 1787.doi:10.1002/lary.28692.PMC7228304.PMID32237238.ProQuest2398912838.
  4. ^abcdefghi"Ageusia (Loss of Sense of Taste): Definition, Causes & Treatment".Cleveland Clinic.Retrieved2024-04-14.
  5. ^abcdefghijklmnopqrstuvDoty RL (2014)."Ageusia".In Aminoff MJ (ed.).Encyclopedia of the Neurological Sciences(2nd ed.). Academic Press. pp. 69–71.doi:10.1016/B978-0-12-385157-4.01112-X.ISBN9780123851581.
  6. ^abAl-Ani RM, Acharya D (October 2022)."Prevalence of Anosmia and Ageusia in Patients with COVID-19 at a Primary Health Center, Doha, Qatar".Indian Journal of Otolaryngology and Head and Neck Surgery.74(Suppl 2): 2703–2709.doi:10.1007/s12070-020-02064-9.PMC7435125.PMID32837952.
  7. ^abcdefgGibbons JR, Sadiq NM (May 1, 2023)."Neuroanatomy, Neural Taste Pathway".StatPearls.Treasure Island (FL): StatPearlsPublishing.PMID31424820.
  8. ^abcdefAbduljabbar T, Alhamdan RS, Al Deeb M, AlAali KA, Vohra F (December 2020)."Association of Salivary Content Alteration and Early Ageusia Symptoms in COVID-19 Infections: A Systematic Review".European Journal of Dentistry.14(S 01): S152–S158.doi:10.1055/s-0040-1716986.PMC7775251.PMID33242917.
  9. ^abTanasa IA, Manciuc C, Carauleanu A, Navolan DB, Bohiltea RE, Nemescu D (September 2020) [September 2020]."Anosmia and ageusia associated with coronavirus infection (COVID-19) - what is known?".Experimental and Therapeutic Medicine.20(3): 2344–2347.doi:10.3892/etm.2020.8808.PMC7401831.PMID32765712.
  10. ^abcSaniasiaya J, Islam MA, Abdullah B (July 2021)."Prevalence and Characteristics of Taste Disorders in Cases of COVID-19: A Meta-analysis of 29,349 Patients"(PDF).Otolaryngology–Head and Neck Surgery.165(1): 33–42.doi:10.1177/0194599820981018.PMID33320033.
  11. ^Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. (August 2020)."Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study".European Archives of Oto-Rhino-Laryngology.277(8): 2251–2261.doi:10.1007/s00405-020-05965-1.PMC7134551.PMID32253535.
  12. ^Saniasiaya J, Islam MA, Abdullah B (July 2021)."Prevalence and Characteristics of Taste Disorders in Cases of COVID-19: A Meta-analysis of 29,349 Patients"(PDF).Otolaryngology–Head and Neck Surgery.165(1): 33–42.doi:10.1177/0194599820981018.PMID33320033.
  13. ^ab"Ageusia: Causes, Symptoms And Treatment".Netmeds.Retrieved2021-03-26.
  14. ^ab"Taste Disorders: Get Facts About Causes, Treatment & Symptoms".MedicineNet.Retrieved2021-03-26.
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