Anisocytosisis a medical term meaning that a patient'sred blood cellsare of unequal size. This is commonly found inanemiaand other blood conditions. False diagnostic flagging may be triggered on acomplete blood countby an elevatedWBCcount, agglutinated RBCs, RBC fragments,giant plateletsor platelet clumps due to anisocytosis. In addition, it is a characteristic feature of bovine blood.
| Anisocytosis | |
|---|---|
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| Human red blood cells from a case of anisocytosis. |
Thered cell distribution width(RDW) is a measurement of anisocytosis[1]and is calculated as a coefficient of variation of the distribution of RBC volumes divided by the mean corpuscular volume (MCV).
Types
editAnisocytosis is identified by RDW and is classified according to the size of RBC measured byMCV.According to this, it can be divided into
- Anisocytosis withmicrocytosis–Iron deficiency,sickle cell anemia
- Anisocytosis withmacrocytosis–Folateorvitamin B12deficiency,autoimmune hemolytic anemia,cytotoxic chemotherapy,chronic liver disease,myelodysplastic syndrome
Increased RDW is seen iniron deficiency anemiaand decreased or normal inthalassemiamajor (Cooley's anemia), thalassemia intermedia
- Anisocytosis with normal RBC size – Early iron, vit B12 or folate deficiency,dimorphic anemia,Sickle cell disease, chronic liver disease, myelodysplastic syndrome[2]
Etymology
editFromAncient Greek:an- without, or negative quality,iso- equal,cyt- cell, -osiscondition.[3]
See also
editReferences
edit- ^Barbara J. Bain(2006).Blood cells: a practical guide.Wiley-Blackwell. pp. 66–.ISBN978-1-4051-4265-6.Retrieved10 November2010.
- ^Red Cell Distribution Width (RDW)ateMedicine
- ^"Archived copy"(PDF).Archived fromthe original(PDF)on 2018-08-20.Retrieved2018-05-19.
{{cite web}}:CS1 maint: archived copy as title (link)
External links
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