Bay K8644

Bay K8644^[1]
Names
	Preferred IUPAC name Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Identifiers
CAS Number	71145-03-4;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:34555;
ChEMBL	ChEMBL1082832;
ChemSpider	2213;
ECHA InfoCard	100.163.930
EC Number	636-102-2;
IUPHAR/BPS	2511;
PubChemCID	2303;
CompTox Dashboard(EPA)	DTXSID301017346 DTXSID00913080, DTXSID301017346;
	InChI InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 Key: ZFLWDHHVRRZMEI-UHFFFAOYSA-N; InChI=1/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 Key: ZFLWDHHVRRZMEI-UHFFFAOYAV;
	SMILES CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC;
Properties
Chemical formula	C16H15F3N2O4
Molar mass	356.301g·mol−1
Solubility in water	Insoluble
Solubilityin other solvents	DMSO:184 mg/mL;methanolandethanol:63 mg/mL
Hazards
	GHSlabelling:
Pictograms
Signal word	Warning
Hazard statements	H315,H319
Precautionary statements	P264,P280,P302+P352,P305+P351+P338,P321,P332+P313,P337+P313,P362
	Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa). verify(what is?) Infobox references

Bay K8644is achemical compoundthat functions as anL-type calcium channel agonist.Bay K8644 is used primarily as a biochemical research tool for this effect.^[2]It is a structural analog ofnifedipinewith positive inotropic activity, and as an aromatic it is highly lipid soluble.

Mechanism of action

Bay K8644 targetsL-type voltage-gated calcium channels.It is the first positive inotropic agent shown to act specifically and directly on calcium channels.^[3]

References

^(±)-Bay K8644atSigma-Aldrich
^CID 2303fromPubChem
^Thomas, G; Chung, M; Cohen, CJ (January 1985)."A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent".Circ Res.56(1): 87–96.doi:10.1161/01.res.56.1.87.PMID 2578336.

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[1] (±)-Bay K8644atSigma-Aldrich

[2] CID 2303fromPubChem

[3] Thomas, G; Chung, M; Cohen, CJ (January 1985)."A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent".Circ Res.56(1): 87–96.doi:10.1161/01.res.56.1.87.PMID 2578336.

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