Chemokine (C-C motif) ligand 26(CCL26) is a smallcytokinebelonging to the CCchemokinefamily that is also calledEotaxin-3,Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues includingheart,lungandovary,and inendothelial cellsthat have been stimulated with thecytokineinterleukin 4.[1][2]CCL26 is chemotactic foreosinophilsandbasophilsand elicits its effects by binding to the cell surfacechemokine receptorCCR3.[3]This gene for chemokine is located on humanchromosome 7.[4]
| chemokine (C-C motif) ligand 26 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCL26 | ||||||
| Alt. symbols | SCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1 | ||||||
| NCBI gene | 10344 | ||||||
| HGNC | 10625 | ||||||
| OMIM | 604697 | ||||||
| PDB | 1G2T | ||||||
| RefSeq | NM_006072 | ||||||
| UniProt | Q9Y258 | ||||||
| Other data | |||||||
| Locus | Chr. 7q11.2 | ||||||
| |||||||
References
edit- ^Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
- ^Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
- ^Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
- ^Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.
External links
edit- CCL26human gene location in theUCSC Genome Browser.
- CCL26human gene details in theUCSC Genome Browser.
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