Geiparvarin

Geiparvarin
Names
	Preferred IUPAC name 7-{[(2E)-3-(5,5-Dimethyl-4-oxo-4,5-dihydrofuran-2-yl)but-2-en-1-yl]oxy}-2H-1-benzopyran-2-one
Identifiers
CAS Number	36413-91-9;
3D model (JSmol)	Interactive image; Interactive image;
ChemSpider	4743982;
MeSH	Geiparvarin
PubChemCID	5910585;
UNII	O0M5JB2L95;
CompTox Dashboard(EPA)	DTXSID201026772;
	InChI InChI=1S/C19H18O5/c1-12(15-11-17(20)19(2,3)24-15)8-9-22-14-6-4-13-5-7-18(21)23-16(13)10-14/h4-8,10-11H,9H2,1-3H3/b12-8+ Key: OUTLLBZGJYDUQE-XYOKQWHBSA-N; InChI=1/C19H18O5/c1-12(15-11-17(20)19(2,3)24-15)8-9-22-14-6-4-13-5-7-18(21)23-16(13)10-14/h4-8,10-11H,9H2,1-3H3/b12-8+ Key: OUTLLBZGJYDUQE-XYOKQWHBBW;
	SMILES CC(=CCOC1=CC2=C(C=C1)C=CC(=O)O2)C3=CC(=O)C(O3)(C)C; O=C/3Oc2c(ccc(OC/C=C(/C=1OC(C(=O)C=1)(C)C)C)c2)\C=C\3;
Properties
Chemical formula	C19H18O5
Molar mass	326.343 g/mol
Density	1.242 g/mL
Boiling point	533 °C (991 °F; 806 K)
	Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa). verify(what is?) Infobox references

Geiparvarinis acoumarinderivative found in the leaves of the Australian Willow (Geijera parviflora).^[1]It is amonoamine oxidase inhibitor.^[2]

Severalanaloguesof geiparvarin have been studied for antitumor properties.^[3]^[4]^[5]

References

^Lahey FN, Macleod JK (September 1967). "The coumarins ofGeijera parvifloraLindl ".Aust J Chem.20(9): 1943–55.doi:10.1071/CH9671943.
^Carotti A, Carrieri A, Chimichi S, et al. (December 2002). "Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies".Bioorg. Med. Chem. Lett.12(24): 3551–3555.doi:10.1016/S0960-894X(02)00798-9.PMID 12443774.
^Baraldi PG, Guarneri M, Manfredini S, Simoni D, Balzarini J, De Clercq E (February 1989). "Synthesis and cytostatic activity of geiparvarin analogues".J Med Chem.32(2): 284–288.doi:10.1021/jm00122a002.PMID 2913291.
^Valenti P, Rampa A, Recanatini M, et al. (September 1997). "Synthesis, cytotoxicity and SAR of simple geiparvarin analogues".Anticancer Drug Des.12(6): 443–51.PMID 9311554.
^Viola G, Vedaldi D, dall'Acqua F, et al. (September 2004). "Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues".Chemistry & Biodiversity.1(9): 1265–1280.doi:10.1002/cbdv.200490089.PMID 17191904.S2CID 22355393.

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