Aglucuronide,also known asglucuronoside,is any substance produced by linkingglucuronic acidto another substance via aglycosidic bond.[1]The glucuronides belong to theglycosides.
Glucuronidation,the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as anenergysource. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher watersolubilitythan the original substance, is eventually excreted by thekidneys.[2]
Enzymes that cleave the glycosidic bond of a glucuronide are calledglucuronidases.
Examples
edit- Miquelianin(Quercetin3-O-glucuronide)
- Morphine-6-glucuronide
- Scutellarein-7-glucuronide
References
edit- ^The American Heritage Medical Dictionary,2007, Houghton Mifflin Company
- ^Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, et al. (May 2017)."Glucuronidation: driving factors and their impact on glucuronide disposition".Drug Metabolism Reviews.49(2): 105–138.doi:10.1080/03602532.2017.1293682.PMC7660525.PMID28266877.
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