Leukotriene-C4 synthase

The enzymeleukotriene-C₄synthase(EC 4.4.1.20)catalyzesthe reaction

leukotriene-C4synthase
Leukotriene C4synthase dodecamer, Human
Identifiers
EC no.	4.4.1.20
CAS no.	90698-32-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDBstructures	RCSB PDBPDBePDBsum
Gene Ontology	AmiGO/QuickGO
Search PMC articles PubMed articles NCBI proteins

leukotriene C₄$\rightleftharpoons$leukotriene A₄+ glutathione

This enzyme belongs to the family oflyases,specifically the class of carbon-sulfur lyases. Thesystematic nameof this enzyme class isleukotriene-C₄glutathione-lyase (leukotriene-A₄-forming).Other names in common use includeleukotriene C₄synthetase,LTC4 synthase,LTC4 synthetase,leukotriene A₄:glutathioneS-leukotrienyltransferase,(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening),(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming).This enzyme participates inarachidonic acid metabolism.

Structural studies

As of late 2007, 3structureshave been solved for this class of enzymes, withPDBaccession codes2PNO,2UUH,and2UUI.

References

• Bach MK, Brashler JR, Morton DR Jr (1984). "Solubilization and characterization of the leukotriene C₄synthetase of rat basophil leukemia cells: a novel, particulate glutathioneS-transferase ".Arch. Biochem. Biophys.230(2): 455–65.doi:10.1016/0003-9861(84)90426-0.PMID6324687.
• Shimizu T (1988). "Enzymes functional in the syntheses of leukotrienes and related compounds".Int. J. Biochem.20(7): 661–6.doi:10.1016/0020-711X(88)90160-7.PMID2846379.
• Lam BK, Austen KF (2002). "Leukotriene C₄synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes ".Prostaglandins. Other. Lipid. Mediat.68–69: 511–20.doi:10.1016/S0090-6980(02)00052-7.PMID12432940.
• Christmas P, Weber BM, McKee M, Brown D, Soberman RJ (2002)."Membrane localization and topology of leukotriene C₄synthase ".J. Biol. Chem.277(32): 28902–8.doi:10.1074/jbc.M203074200.PMID12023288.