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Li–Fraumeni syndrome

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Li–Fraumeni syndrome(LFS) is a rare,autosomal dominant,hereditary disorder[1]thatpredisposes carriers to cancer development.It was named after two American physicians,Frederick Pei LiandJoseph F. Fraumeni Jr.,who first recognized the syndrome after reviewing the medical records and death certificates of childhoodrhabdomyosarcomapatients.[2]The disease is also known asSBLA,for the Sarcoma, Breast, Leukemia, and Adrenal Gland cancers that it is known to cause.[3][4]

Li–Fraumeni syndrome
Other namesSarcoma family syndrome of Li and Fraumeni, SBLA
Li–Fraumeni syndrome is inherited via an autosomal dominant manner
SpecialtyOncology,medical genetics,neurologyEdit this on Wikidata

Etiology

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LFS is caused bygermline mutations(also called genetic variants) in theTP53tumor suppressor gene,[5]which encodes a transcription factor (p53) that normally regulates the cell cycle and prevents genomic mutations. The variants can beinherited,or can arise from mutations early inembryogenesis,or in one of the parent'sgerm cells.

LFS is thought to occur in about 1 in 5,000 individuals in the general population. In Brazil there is a common founder variant, p.Arg337, that occurs in about 1 in every 375 people.[6]LFS is inherited in an autosomal dominant fashion which means that a person with LFS has a 50% chance to pass the syndrome on in every pregnancy (and a 50% chance tonotpass on the syndrome).[7]

Clinical presentation

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Li–Fraumeni syndrome is characterized by early onset of cancer, a wide variety of types of cancers, and development of multiple cancers throughout one's life.[8]

LFS:Mutations inTP53

TP53is atumor suppressor geneon chromosome 17 that normally assists in the control of cell division and growth through action on the normalcell cycle.TP53typically becomes expressed due to cellular stressors, such as DNA damage, and can halt the cell cycle to assist with either the repair of repairable DNA damage, or can induceapoptosisof a cell with irreparable damage. The repair of "bad" DNA, or the apoptosis of a cell, prevents the proliferation of damaged cells and the development of cancer.[9]

Pathogenic and likely pathogenic variants in theTP53gene can inhibit its normal function and allow cells with damaged DNA to continue to divide. If these DNA mutations are left unchecked, some cells can divide uncontrollably, forming tumors (cancers). Many individuals with Li–Fraumeni syndrome have been shown to be heterozygous for aTP53variant. Recent studies have shown that 60% to 80% of classic LFS families harbor detectable germ-lineTP53mutations, the majority of which aremissense mutationsin the DNA-binding domain.[10]These missense mutations cause a decrease in the ability of p53 to bind to DNA, thus inhibiting the normalTP53mechanism.[11]

LFS-Like (LFS-L):

Families who do not conform to the criteria of classical Li–Fraumeni syndrome have been termed "LFS-Like".[10]LFS-L individuals generally do not have any detectableTP53variants, and tend to meet either the Birch or Eeles criteria.

Clinical

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The classical LFS malignancies—sarcoma, cancers of the breast, brain, and adrenal glands—comprise about 80% of all cancers that occur in this syndrome.

The risk of developing any invasive cancer (excluding skin cancer) is about 50% by age 30 (1% in the general population) and is 90% by age 70. Early-onset breast cancer accounts for 25% of all the cancers in this syndrome. This is followed by soft-tissue sarcomas (20%), bone sarcoma (15%), and brain tumors—especiallyglioblastomas—(13%). Other tumours seen in this syndrome includeleukemia,lymphoma,and adrenocortical carcinoma.

The table below depicts tumor site distribution of variants for families followed in the LFS Study at the National Cancer Institute's (NCI) Division of Cancer Epidemiology and Genetics (DCEG): About 95% of females with LFS develop breast cancer by age 60 years; the majority of these occur before age 45 years lending females with this syndrome to have almost a 100% lifetime risk of developing cancer.

Cancer Risks by Sex and Age[6]

Age 20 years old 40 years old 60 years old

Men25% 40% 88%

Women18% 75% >95%

Diagnosis

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Germline variants in theTP53tumor suppressor gene was discovered to be the primary cause of Li-Fraumeni syndrome in 1990.[12][13]

Li–Fraumeni syndrome is diagnosed if a person has a pathogenic or likely pathogenicTP53variant and/or if these three Classic Criteria are met:[14]

  • The patient has been diagnosed with a sarcoma at a young age (below 45).
  • A first-degree relative has been diagnosed with any cancer at a young age (below 45).
  • Another first- or a second-degree relative has been diagnosed with any cancer at a young age (below 45) or with a sarcoma at any age.

LFS should also be suspected in individuals who meet other published criteria.

2015 Revised Chompret Criteria:[15]

  • A proband with a tumor belonging to the LFS tumor spectrum (premenopausal breast cancer, soft tissue sarcoma, osteosarcoma, central nervous system (CNS) tumor, adrenocortical carcinoma) before age 46 years AND at least one first- or second-degree relative with an LFS tumor (except breast cancer if the proband has breast cancer) before age 56 years or with multiple tumors; OR
  • A proband with multiple tumors (except multiple breast tumors), two of which belong to the LFS tumor spectrum and the first of which occurred before age 46 years; OR
  • A proband with adrenocortical carcinoma, choroid plexus tumor, or rhabdomyosarcoma of embryonal anaplastic subtype, irrespective of family history; OR
  • Breast cancer before age 31 years

Birch Criteria for Li Fraumeni-like syndrome:[16]

  • A proband with any childhood cancer, sarcoma, brain tumor, or adrenal cortical carcinoma diagnosed before age 45, AND
  • A first- or second-degree relative with a typical LFS malignancy (sarcoma, leukemia, or cancers of the breast, brain or adrenal cortex) regardless of age at diagnosis, AND
  • A first- or second-degree relative with any cancer diagnosed before age 60

Eeles Criteria for Li Fraumeni-like Syndrome:[17]

  • Two different tumors that are part of extended LFS in first- or second-degree relatives at any age (sarcoma, breast cancer, brain tumor, leukemia, adrenocortical carcinoma, melanoma, prostate cancer, and pancreatic cancer).

If an individual has a personal or family history concerning for LFS, they should discuss the risks, benefits, and limitations of genetic testing with their healthcare provider or a genetic counselor.


Management

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Genetic counselingandgenetic testingfor theTP53gene can confirm a diagnosis of LFS.[18]People with LFS require early and regular cancer screening following the "Toronto Protocol":[18][19][20]

  • Children and adults undergo comprehensive annual physical examinations every 6 to 12 months
  • All patients consult a physician promptly for evaluation of lingering symptoms and illnesses
  • Ultrasound of abdomen and pelvis every 3 to 4 months from birth to age 18 years
  • Colonoscopy and upper endoscopy every 2 to 5 years beginning at age 25 or 5 years before the earliest known GI cancer in the family
  • Annual dermatological exam starting at age 18 years
  • Annual whole-body MRI
  • Annual brain MRI and neurological exam
  • Annual prostate-specific antigen (PA) starting at age 40
  • Breast awareness beginning at age 18
  • Clinical breast exam every 6 to 12 months starting at age 20
  • Annual breast MRI age 20 to 29; annual breast MRI alternating with mammogram age 30 to 75
  • Consideration of risk-reducing mastectomy (surgery to remove the breast tissue)
  • Families and individuals should consider participating in a peer-support group[21][22]

References

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  1. ^Custódio G, Parise GA, Kiesel Filho N, Komechen H, Sabbaga CC, Rosati R, et al. (July 2013)."Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors".Journal of Clinical Oncology.31(20): 2619–2626.doi:10.1200/JCO.2012.46.3711.PMC3808236.PMID23733769.
  2. ^Li FP, Fraumeni JF (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?".Annals of Internal Medicine.71(4): 747–752.doi:10.7326/0003-4819-71-4-747.PMID5360287.S2CID7540982.
  3. ^Evans DG, Hanson H (13 March 2024)."Li-Fraumeni syndrome".UpToDate.Wolters Kluwer.Retrieved20 August2024.
  4. ^Aedma SK, Kasi A (2024)."Li-Fraumeni Syndrome".StatPearls.StatPearls Publishing.PMID30335319.
  5. ^Varley JM (March 2003)."Germline TP53 mutations and Li-Fraumeni syndrome".Human Mutation.21(3): 313–320.doi:10.1002/humu.10185.PMID12619118.
  6. ^abMai PL, Best AF, Peters JA, DeCastro RM, Khincha PP, Loud JT, et al. (December 2016)."Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort".Cancer.122(23): 3673–3681.doi:10.1002/cncr.30248.PMC5115949.PMID27496084.
  7. ^de Andrade KC, Frone MN, Wegman-Ostrosky T, Khincha PP, Kim J, Amadou A, et al. (January 2019)."Variable population prevalence estimates of germline TP53 variants: A gnomAD-based analysis".Human Mutation.40(1): 97–105.doi:10.1002/humu.23673.PMC6296902.PMID30352134.
  8. ^Hisada M, Garber JE, Fung CY, Fraumeni JF, Li FP (April 1998)."Multiple primary cancers in families with Li-Fraumeni syndrome".Journal of the National Cancer Institute.90(8): 606–611.doi:10.1093/jnci/90.8.606.PMID9554443.
  9. ^Zerdoumi Y, Lanos R, Raad S, Flaman JM, Bougeard G, Frebourg T, et al. (July 2017)."Germline TP53 mutations result into a constitutive defect of p53 DNA binding and transcriptional response to DNA damage".Human Molecular Genetics.26(14): 2591–2602.doi:10.1093/hmg/ddx106.PMC5886078.PMID28369373.
  10. ^abMalkin D (2011). "Li-Fraumeni Syndrome". In Levine AJ (ed.).Genes and Cancer.Vol. 2. pp. 475–484.doi:10.1177/1947601911413466.PMC3135649.PMID21779515.
  11. ^Ford JM, Hanawalt PC (September 1995)."Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance".Proceedings of the National Academy of Sciences of the United States of America.92(19): 8876–8880.doi:10.1073/pnas.92.19.8876.PMC41070.PMID7568035.
  12. ^Malkin D, Li FP, Strong LC, Fraumeni JF, Nelson CE, Kim DH, et al. (November 1990). "Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms".Science.250(4985): 1233–1238.doi:10.1126/science.1978757.PMID1978757.
  13. ^Srivastava S, Zou ZQ, Pirollo K, Blattner W, Chang EH (December 1990). "Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome".Nature.348(6303): 747–749.doi:10.1038/348747a0.PMID2259385.
  14. ^Li FP, Garber JE, Dreyfus MG, Blattner WA, Fraumeni JF, Sandberg AA (January 1990). "Follow-up of cancer family with in-vitro radioresistance".Lancet.335(8682): 176–177.doi:10.1016/0140-6736(90)90056-b.PMID1967474.
  15. ^Bougeard G, Renaux-Petel M, Flaman JM, Charbonnier C, Fermey P, Belotti M, et al. (July 2015). "Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers".Journal of Clinical Oncology.33(21): 2345–2352.doi:10.1200/JCO.2014.59.5728.PMID26014290.
  16. ^Birch JM, Heighway J, Teare MD, Kelsey AM, Hartley AL, Tricker KJ, et al. (December 1994)."Linkage studies in a Li-Fraumeni family with increased expression of p53 protein but no germline mutation in p53".British Journal of Cancer.70(6): 1176–1181.doi:10.1038/bjc.1994.468.PMC2033684.PMID7981072.
  17. ^Eeles RA (January 1993). "Predictive testing for germline mutations in the p53 gene: are all the questions answered?".European Journal of Cancer.29A(10): 1361–1365.doi:10.1016/0959-8049(93)90001-v.PMID8398258.
  18. ^abKratz CP, Achatz MI, Brugières L, Frebourg T, Garber JE, Greer MC, et al. (June 2017)."Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome".Clinical Cancer Research.23(11): e38–e45.doi:10.1158/1078-0432.CCR-17-0408.PMID28572266.
  19. ^Villani A, Shore A, Wasserman JD, Stephens D, Kim RH, Druker H, et al. (September 2016). "Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study".The Lancet. Oncology.17(9): 1295–1305.doi:10.1016/S1470-2045(16)30249-2.PMID27501770.
  20. ^Vogel WH (2017)."Li-Fraumeni Syndrome".Journal of the Advanced Practitioner in Oncology.8(7): 742–746.PMC6188099.PMID30333936.
  21. ^Plumridge G, Metcalfe A, Coad J, Gill P (September 2012)."The role of support groups in facilitating families in coping with a genetic condition and in discussion of genetic risk information".Health Expectations: An International Journal of Public Participation in Health Care and Health Policy.15(3): 255–266.doi:10.1111/j.1369-7625.2011.00663.x.ISSN1369-7625.PMC5060625.PMID21332619.
  22. ^Association LF."Home".LFS Association.Retrieved2024-07-20.

Further reading

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