Mybgenesare part of a largegene familyoftranscription factorsfound in animals and plants. In humans, it includesMyb proto-oncogene like 1andMyb-related protein Bin addition toMYBproper.[5][6]Members of the extendedSANT/Mybfamily also include theSANT domainand other similar all-helicalhomeobox-like domains.
| Myb-like DNA-binding domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Myb_DNA-binding | ||||||||
| Pfam | PF00249 | ||||||||
| InterPro | IPR001005 | ||||||||
| PROSITE | PDOC00037 | ||||||||
| CATH | 1irz | ||||||||
| SCOP2 | 1irz/SCOPe/SUPFAM | ||||||||
| CDD | cd00167 | ||||||||
| |||||||||
Function
editViral
editThe Myb gene family is named after the eponymous gene inAvian myeloblastosis virus.The viral Myb (v-Myb,P01104) recognizes the sequence 5'-YAACKG-3'. It causes myeloblastosis (myeloid leukemia) in chickens.[7]Compared to the normal animal cellular Myb (c-myb), v-myb contains deletions in the C-terminal regulatory domain, leading to aberrant activation of other oncogenes.[8]
Animals
editMyb proto-oncogene protein is a member of the MYB (myeloblastosis) family oftranscription factors.The protein contains three domains, anN-terminalDNA-binding domain,a central transcriptional activation domain and a C-terminal domain involved in transcriptionalrepression.It may play a role in cell cycle regulation. Like the viral version, this gene is anoncogene,and rearrangements of the gene (often involving deletion in the C-terminal domain) causes cancer.[8]
Plants
editMYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain.[9]
In maize,phlobaphenesare synthesized in the flavonoids synthetic pathway[10]from polymerisation offlavan-4-ols[11][12]which encodes an R2R3 myb-liketranscriptional activator[13]of the A1 gene encoding for thedihydroflavonol 4-reductase(reducingdihydroflavonolsinto flavan-4-ols)[14]while another gene (Suppressor of Pericarp Pigmentation 1 or SPP1) acts as asuppressor.[15]The maize P gene encodes a Myb homolog that recognizes the sequence CCWACC, in sharp contrast with the YAACGG bound by vertebrate Myb proteins.[16]
In sorghum, the corresponding yellow seed 1 gene (y1)[17]also encodes a R2R3 type of Myb domain protein that regulates the expression ofchalcone synthase,chalcone isomeraseanddihydroflavonol reductasegenes required for the biosynthesis of3-deoxyflavonoids.[18]
Ruby is a MYB transcriptional activator of genes that produceanthocyaninin citrus fruits. In most citrus varieties Ruby is non-functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit.[19]
See also
editReferences
edit- ^abcGRCh38: Ensembl release 89: ENSG00000118513–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000019982–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells".Biochem Biophys Res Commun.360(2): 433–6.doi:10.1016/j.bbrc.2007.06.078.PMID17599807.
- ^"Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".
- ^Klempnauer KH, Symonds G, Evan GI, Bishop JM (June 1984). "Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene".Cell.37(2): 537–47.doi:10.1016/0092-8674(84)90384-2.PMID6327074.S2CID46196167.
- ^abGeorge OL, Ness SA (October 2014)."Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis".Cancers.6(4): 2049–71.doi:10.3390/cancers6042049.PMC4276956.PMID25279451.
- ^Stracke R, Werber M, Weisshaar B (October 2001). "The R2R3-MYB gene family in Arabidopsis thaliana".Curr. Opin. Plant Biol.4(5): 447–56.Bibcode:2001COPB....4..447S.doi:10.1016/s1369-5266(00)00199-0.PMID11597504.
- ^Himi E, Mares DJ, Yanagisawa A, Noda K (July 2002)."Effect of grain colour gene (R) on grain dormancy and sensitivity of the embryo to abscisic acid (ABA) in wheat".J. Exp. Bot.53(374): 1569–74.doi:10.1093/jxb/erf005.PMID12096095.
- ^Winkel-Shirley B (June 2001)."Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology".Plant Physiol.126(2): 485–93.doi:10.1104/pp.126.2.485.PMC1540115.PMID11402179.
- ^Chopra S, Cocciolone SM, Bushman S, Sangar V, McMullen MD, Peterson T (March 2003)."The maize unstable factor for orange1 is a dominant epigenetic modifier of a tissue specifically silent allele of pericarp color1".Genetics.163(3): 1135–46.doi:10.1093/genetics/163.3.1135.PMC1462483.PMID12663550.
- ^Structural And Transcriptional Analysis Of The Complex P1-wr Cluster In Maize. Wolfgang Goettel, Joachim Messing. Plant & Animal Genomes XVI ConferenceArchived2012-02-18 at theWayback Machine
- ^Dong X, Braun EL, Grotewold E (September 2001)."Functional conservation of plant secondary metabolic enzymes revealed by complementation of Arabidopsis flavonoid mutants with maize genes"(PDF).Plant Physiol.127(1): 46–57.doi:10.1104/pp.127.1.46.hdl:1811/48809.PMC117961.PMID11553733.
- ^Lee EA, Harper V (2002). "Suppressor of Pericarp Pigmentation 1 (SPP1), a novel gene involved in phlobaphene accumulation in maize (Zea mays L.) pericarps".Maydica.47(1): 51–58.INIST13772300
- ^Grotewold E, Drummond BJ, Bowen B, Peterson T (1994). "The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset".Cell.76(3): 543–554.doi:10.1016/0092-8674(94)90117-1.PMID8313474.S2CID42197232.
- ^Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S (2005). "Characterization of a deletion allele of a sorghum Myb gene yellow seedl showing loss of 3-deoxyflavonoids".Plant Science.169(3): 542–552.doi:10.1016/j.plantsci.2005.05.007.INIST16983977
- ^Boddu J, Jiang C, Sangar V, Olson T, Peterson T, Chopra S (January 2006). "Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis".Plant Mol. Biol.60(2): 185–99.doi:10.1007/s11103-005-3568-1.PMID16429259.S2CID23841582.
- ^Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato-Recupero G, Martin C (2012)."Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges".Plant Cell.24(3): 1242–55.doi:10.1105/tpc.111.095232.PMC3336134.PMID22427337.
Further reading
edit- Oh IH, Reddy EP (1999)."The myb gene family in cell growth, differentiation and apoptosis".Oncogene.18(19): 3017–33.doi:10.1038/sj.onc.1202839.PMID10378697.
- Nicolaides NC, Gualdi R, Casadevall C, Manzella L, Calabretta B (1991)."Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene".Mol. Cell. Biol.11(12): 6166–76.doi:10.1128/mcb.11.12.6166-6176.1991.PMC361795.PMID1944282.
- Kalkbrenner F, Guehmann S, Moelling K (1990). "Transcriptional activation by human c-myb and v-myb genes".Oncogene.5(5): 657–61.PMID2189102.
- Westin EH, Gorse KM, Clarke MF (1990). "Alternative splicing of the human c-myb gene".Oncogene.5(8): 1117–24.PMID2202948.
- Dasgupta P, Reddy EP (1990). "Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences".Oncogene.4(12): 1419–23.PMID2687764.
- Janssen JW, Vernole P, de Boer PA, Oosterhuis JW, Collard JG (1986). "Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements".Cytogenet. Cell Genet.41(3): 129–35.doi:10.1159/000132217.PMID3007038.
- Slamon DJ, Boone TC, Murdock DC, Keith DE, Press MF, Larson RA, Souza LM (1986). "Studies of the human c-myb gene and its product in human acute leukemias".Science.233(4761): 347–51.Bibcode:1986Sci...233..347S.doi:10.1126/science.3014652.PMID3014652.
- Majello B, Kenyon LC, Dalla-Favera R (1987)."Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus".Proc. Natl. Acad. Sci. U.S.A.83(24): 9636–40.doi:10.1073/pnas.83.24.9636.PMC387195.PMID3540945.
- Szczylik C, Skorski T, Ku DH, Nicolaides NC, Wen SC, Rudnicka L, Bonati A, Malaguarnera L, Calabretta B (1993)."Regulation of proliferation and cytokine expression of bone marrow fibroblasts: role of c-myb".J. Exp. Med.178(3): 997–1005.doi:10.1084/jem.178.3.997.PMC2191153.PMID7688794.
- Krieg J, Oelgeschläger M, Janknecht R, Lüscher B (1995). "High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains".Oncogene.10(11): 2221–8.PMID7784067.
- Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene".Oncogene.9(1): 227–35.PMID8302584.
- Favier D, Gonda TJ (1994). "Detection of proteins that bind to the leucine zipper motif of c-Myb".Oncogene.9(1): 305–11.PMID8302594.
- Glaser R, Lafuse WP, Bonneau RH, Atkinson C, Kiecolt-Glaser JK (1993). "Stress-associated modulation of proto-oncogene expression in human peripheral blood leukocytes".Behav. Neurosci.107(3): 525–9.doi:10.1037/0735-7044.107.3.525.PMID8329139.
- Dash AB, Orrico FC, Ness SA (1996)."The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb".Genes Dev.10(15): 1858–69.doi:10.1101/gad.10.15.1858.PMID8756344.
- Vorbrueggen G, Lovrić J, Moelling K (1997). "Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase".Biol. Chem.377(11): 721–30.doi:10.1515/bchm3.1996.377.11.721.PMID8960373.
- Tavner FJ, Simpson R, Tashiro S, Favier D, Jenkins NA, Gilbert DJ, Copeland NG, Macmillan EM, Lutwyche J, Keough RA, Ishii S, Gonda TJ (1998)."Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb".Mol. Cell. Biol.18(2): 989–1002.doi:10.1128/MCB.18.2.989.PMC108811.PMID9447996.
- Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998)."c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation".Mol. Cell. Biol.18(5): 2729–37.doi:10.1128/mcb.18.5.2729.PMC110652.PMID9566892.
- Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (1998)."Pim-1 kinase and p100 cooperate to enhance c-Myb activity".Mol. Cell.2(4): 417–25.doi:10.1016/S1097-2765(00)80141-0.PMID9809063.
- Thompson MA, Rosenthal MA, Ellis SL, Friend AJ, Zorbas MI, Whitehead RH, Ramsay RG (1998). "c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression".Cancer Res.58(22): 5168–75.PMID9823328.
- Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP (1999)."C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters".Blood.93(10): 3327–37.doi:10.1182/blood.V93.10.3327.PMID10233885.
External links
edit- MYB+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- DrosophilaMyb oncogene-like- The Interactive Fly
- Arabidospsis thalianaMYB family at Database of Arabidopsis Transcription Factors (DATF)
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.