Nedocromil

Nedocromil
Clinical data
Trade names	Alocril
AHFS/Drugs.com	Monograph
MedlinePlus	a601243
Routes of; administration	Inhalationandeye drops
ATC code	R01AC07(WHO)R03BC03(WHO),S01GX04(WHO);
Legal status
Legal status	AU:S4(Prescription only); UK:POM(Prescription only); US:℞-only;
Pharmacokineticdata
Protein binding	89%
Metabolism	not metabolized
Eliminationhalf-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
	IUPAC name 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid;
CAS Number	69049-73-6;
PubChemCID	50294;
IUPHAR/BPS	7607;
DrugBank	DB00716;
ChemSpider	45608;
UNII	0B535E0BN0;
KEGG	D05129;
ChEBI	CHEBI:7492;
ChEMBL	ChEMBL746;
CompTox Dashboard(EPA)	DTXSID7023356;
ECHA InfoCard	100.233.208
Chemical and physical data
Formula	C19H17NO7
Molar mass	371.345g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC;
	InChI InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26); Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N;
	(verify)

Nedocromil sodiumis amedicationconsidered as mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused byasthma.It is administered by aninhalerunder the brand nameTilade,and as aneye dropunder the brand nameAlocril.^[1]^[2]The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators likealbuterolor other well-knowninhalermedications. Liquid preparations of nedocromil are available in theUKunder the nameRapitilfor use for allergic eye reactions.^[3]Nedocromil sodium has been shown to be effective in alleviating symptoms ofallergic conjunctivitis.^[4]

Nedocromil is classified as abenzopyrone.Nedocromil acts as amast cell stabilizer,inhibits the degranulation ofmast cells,prevents release ofhistamineandtryptase,so preventing the synthesis ofprostaglandinsandleukotrienes.US Production of inhaled nedocromil ceased in April 2008 because it usedCFCsas propellant.^[5]

References

Media related toNedocromilat Wikimedia Commons

^"ALOCRIL Product Information".Allergan. Archived fromthe originalon 8 May 2013.Retrieved17 May2013.
^Allen H. Dajani S (ed.)."ALOCRIL (nedocromil sodium) solution/ drops".DailyMed.U.S. National Institutes of Health.Retrieved17 May2013.
^"Nedocromil eye drops".Patient.info.2007-02-02.Retrieved2009-08-04.
^Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015)."Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis"(PDF).The Cochrane Database of Systematic Reviews.2015(6): CD009566.doi:10.1002/14651858.CD009566.pub2.hdl:2164/6048.PMC10616535.PMID 26028608.
^"Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil".U.S. Food and Drug Administration. 13 April 2010. Archived fromthe originalon 2 February 2012.

Thisdrugarticle relating to therespiratory systemis astub.You can help Wikipedia byexpanding it.

[1] "ALOCRIL Product Information".Allergan. Archived fromthe originalon 8 May 2013.Retrieved17 May2013.

[2] Allen H. Dajani S (ed.)."ALOCRIL (nedocromil sodium) solution/ drops".DailyMed.U.S. National Institutes of Health.Retrieved17 May2013.

[3] "Nedocromil eye drops".Patient.info.2007-02-02.Retrieved2009-08-04.

[Castillo-4] Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015)."Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis"(PDF).The Cochrane Database of Systematic Reviews.2015(6): CD009566.doi:10.1002/14651858.CD009566.pub2.hdl:2164/6048.PMC10616535.PMID 26028608.

[5] "Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil".U.S. Food and Drug Administration. 13 April 2010. Archived fromthe originalon 2 February 2012.

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Nedocromil

See also

References