PPADS

PPADS
Names
	IUPAC name 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzene-1,3-disulfonic acid
	Other names PPADS
Identifiers
CAS Number	149017-66-3; 192575-19-2(tetrasodium salt);
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:34941;
ChemSpider	20136164;
PubChemCID	6093163; 6532796(tetrasodium salt);
UNII	L6K2LJ9BJK;
	InChI InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)/b17-16+;
	SMILES Oc2c(C=O)c(COP(O)(=O)O)c(/N=N/c1ccc(cc1S(O)(=O)=O)S(O)(=O)=O)nc2C;
Properties
Chemical formula	C14H14N3O12PS2
Molar mass	511.37g·mol−1
Appearance	Orange solid
Solubility in water	100 mM (tetrasodium salt)
	Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa). Infobox references

PPADS(pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergicP2X antagonist.^[2]It is able to block contractions of rabbit vas deferens induced byATPor α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity atα₁adrenergic,muscarinicM₂andM₃,histamineH₁,and adenosineA₁receptors.^[3]

References

^PPADS tetrasodium salt,Santa Cruz Biotechnology
^Ziganshin, AU (December 1993)."PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder".British Journal of Pharmacology.110(4): 1491–95.doi:10.1111/j.1476-5381.1993.tb13990.x.PMC2175839.PMID 8306091.
^Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses".European Journal of Pharmacology.217(2–3): 217–19.doi:10.1016/0014-2999(92)90877-7.PMID 1330591.

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[1] PPADS tetrasodium salt,Santa Cruz Biotechnology

[Ziganshin-2] Ziganshin, AU (December 1993)."PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder".British Journal of Pharmacology.110(4): 1491–95.doi:10.1111/j.1476-5381.1993.tb13990.x.PMC2175839.PMID 8306091.

[Lambrecht-3] Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses".European Journal of Pharmacology.217(2–3): 217–19.doi:10.1016/0014-2999(92)90877-7.PMID 1330591.

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