Thenucleus raphe obscurusis one of the medullary raphe nuclei. It is located caudal to thenucleus raphe magnus.The nucleus raphe obscurus projects to thecerebellarlobes VI and VII and to crus II along with thenucleus raphe pontis.[1]
| Nucleus raphe obscurus | |
|---|---|
 Section of the medulla oblongata at about the middle of the olive. (Raphe nuclei not labeled, but 'raphe' labeled at left.) | |
| Details | |
| Identifiers | |
| Latin | nucleus raphes obscurus |
| MeSH | D065849 |
| NeuroNames | 740 |
| NeuroLexID | birnlex_1369 |
| TA98 | A14.1.04.319 |
| TA2 | 6037 |
| FMA | 72585 |
| Anatomical terms of neuroanatomy | |
The nucleus raphes obscurus has also been implicated in the modulation of thehypoglossal nerve.It has been observed that theablationof this nucleus causes a change in the firing pattern of thiscranial nerve.[2]
In addition, the nucleus raphe obscurus mediatesexpirationvia the effect ofserotoninand depresses periodic synaptic potentials.[3]It has also been shown that this nucleus stimulates gastrointestinal motor function; microinjections of 5-HT into the nucleus raphe obscurus increase gastric movement.[4]
See also
editReferences
edit- ^Brodal, A (1981).Neurological Anatomy in relation to Clinical Medication(3rd ed.). Oxford Press.ISBN978-0195026948.
- ^Peever, JH; Necakov, A; Duffin, J (2001). "Nucleus raphé obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices".Journal of Applied Physiology.90(1): 269–279.doi:10.1152/jappl.2001.90.1.269.PMID11133919.
- ^Lalley, PM; Benacka, R; Bischoff, AM; Richter, DW (1997). "Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons".Brain Research.747(1): 156–159.doi:10.1016/S0006-8993(96)01233-4.PMID9042541.
- ^Krowicki, ZK; Hornby, PJ (1993). "Serotonin microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway".Journal of Pharmacology and Experimental Therapeutics.265(1): 468–476.PMID8097247.