Robert Joseph Lefkowitz(born April 15, 1943) is an American physician (internist and cardiologist) and biochemist. He is best known for his discoveries that reveal the inner workings of an important family ofG protein-coupled receptors,for which he was awarded the 2012Nobel Prize for ChemistrywithBrian Kobilka.He is currently an Investigator with theHoward Hughes Medical Instituteas well as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry atDuke University.
Robert Lefkowitz | |
|---|---|
 Lefkowitz in Stockholm 2012 | |
| Born | Robert Joseph Lefkowitz April 15, 1943 The Bronx,New York City, US |
| Nationality | American |
| Alma mater | Columbia University |
| Known for | G protein coupled receptors beta-arrestins |
| Spouse(s) | Arna Brandel (divorced) Lynn Tilley (m.1991) |
| Awards | National Medal of Science(2007) BBVA Foundation Frontiers of Knowledge Award(2009) Nobel Prize in Chemistry(2012) |
| Scientific career | |
| Fields |
|
| Institutions | |
| Notable students | Brian Kobilka,[1]Jeffrey Benovic,Michel Bouvier,Marc G. Caron,Richard A. Cerione, Henrik Dohlman,Walter J. Koch,Lee Limbird,[2]Martin J. Lohse,Gang Pei,Lewis "Rusty" Williams,R. Sanders Williams |
Early life
editLefkowitz was born on April 15, 1943, inThe Bronx,New York to Jewish parents Max and Rose Lefkowitz. Their families had emigrated to the United States fromPolandin the late 19th century.[3][4]
After graduating from theBronx High School of Sciencein 1959,[5]he attendedColumbia Collegefrom which he received a Bachelor of Arts in chemistry in 1962.[6]At Columbia, Lefkowitz studied underRonald Breslow.[7]
He graduated fromColumbia University College of Physicians and Surgeonsin 1966 with an M.D. degree. After serving an internship and one year of general medical residency at the College of Physicians and Surgeons, he served as clinical and research associate at theNational Institutes of Healthfrom 1968 to 1970.
Career
editUpon completing his medical residency and research and clinical training in 1973, he was appointed associate professor of medicine and assistant professor of biochemistry at theDuke University Medical Center.In 1977, he was promoted to professor of medicine and in 1982 toJames B. Duke Professorof Medicine atDuke University.[8] He is also a professor of biochemistry and a professor of chemistry. He has been an investigator of the Howard Hughes Medical Institute since 1976 and was an established investigator of the American Heart Association from 1973 to 1976.[8]
Lefkowitz studies receptor biology and signal transduction and is most well known for his detailed characterizations of the sequence, structure and function of the β-adrenergic and related receptors and for the discovery and characterization of the two families of proteins which regulate them, theG protein-coupled receptor(GPCR) kinases and β-arrestins.[9]
Lefkowitz made a remarkable contribution in the mid-1980s when he and his colleagues cloned the gene first for the β-adrenergic receptor, and then rapidly thereafter, for a total of 8 adrenergic receptors (receptors for adrenaline and noradrenaline). This led to the seminal discovery that all GPCRs (which include the β-adrenergic receptor) have a very similar molecular structure. The structure is defined by an amino acid sequence which weaves its way back and forth across the plasma membrane seven times. Today we know that about 1,000 receptors in the human body belong to this same family. The importance of this is that all of these receptors use the same basic mechanisms so that pharmaceutical researchers now understand how to effectively target the largest receptor family in the human body. Today, as many as 30 to 50 percent of all prescription drugs are designed to "fit" like keys into the similarly structured locks of Lefkowitz' receptors—everything from anti-histamines to ulcer drugs to beta blockers that help relieve hypertension, angina and coronary disease.[10]Lefkowitz is among the most highly cited researchers in the fields of biology, biochemistry, pharmacology, toxicology, and clinical medicine according to Thomson-ISI.[11]
Personal life
editLefkowitz is married to Lynn (née Tilley). He has five children and six grandchildren. He was previously married to Arna Brandel.[6]
In 2021, Lefkowitz published a memoir entitledA Funny Thing Happened on the Way to Stockholm: The Adrenaline-Fueled Adventures of an Accidental Scientist.[12]This book was co-authored by Randy Hall, who was a post-doctoral fellow in the Lefkowitz lab in the 1990s. The book describes Lefkowitz's early life, training as a physician, and tenure in the United States Public Health Service (the "Yellow Berets" of the NIH), which began as a means of fulfilling his draft obligation during the Vietnam War but ultimately ignited a lifelong passion for research. The second half of the book describes Lefkowitz's research career and various adventures both before and after his Nobel Prize win. Upon publication in February 2021, the book was named as "New & Noteworthy" byThe New York Times[13]and "one of the week's best science picks" by Nature.[14]
Awards
editLefkowitz has received numerous awards including:
- 2014 Golden Plate Award of theAmerican Academy of Achievement[15]
- 2012Nobel Prize in Chemistry(shared withBrian Kobilka)
- 2009BBVA Foundation Frontiers of Knowledge Award,in the Biomedicine Category.[16]
- 2009 Research Achievement Award,American Heart Association[17]
- 2007National Medal of Science[18][19]
- 2007 TheShaw Prizein Life Science and Medicine[20]
- 2007Albany Medical Center Prizein Medicine and Biomedical Research[21]
- 2003Fondation Lefoulon – Delalande Grand Prix for Science–Institut de France[22]
- 2001Jessie Stevenson Kovalenko Medalof the USA – The National Academy of Sciences[23]
- 1992Bristol-Myers Squibb Award for Distinguished Achievement In Cardiovascular Research[24]
- 1988Gairdner Foundation International Award[25]
- 1978 John Jacob Abel Award in Pharmacology[26]
See also
editReferences
edit- ^"The Nobel Prize in Chemistry 2012".NobelPrize.org.
- ^Snyder, Bill."Nobel in Chemistry reveals VU ties that bind".Vanderbilt University.
- ^Ralph Snyderman (October 3, 2011)."Introduction of Robert J. Lefkowitz".The Journal of Clinical Investigation.121(10). Jci.org:4192–4300.doi:10.1172/JCI60816.PMC3195491.PMID21965339.RetrievedOctober 12,2012.
- ^Jay Price (December 30, 2012)."Dr. Robert Lefkowitz, Nobel in hand, still shapes young researchers".News & Observer. Archived fromthe originalon January 20, 2013.RetrievedJanuary 17,2013.
- ^Newman, Andy (October 10, 2012)."Another Nobel for Bronx Science, This One in Chemistry".New York Times.
- ^ab"Dr. Robert Lefkowitz, Nobel in hand, still shapes young researchers - Local/State - NewsObserver.com".Archived fromthe originalon January 20, 2013.RetrievedJanuary 17,2013.
- ^"Columbia College mourns the loss of University Professor Ronald Breslow".Columbia College.RetrievedJune 15,2024.
- ^ab"HHMI Investigators – Robert J. Lefkowitz, M.D".Howard Hughes Medical Institute.RetrievedJanuary 14,2013.
- ^"Robert J. Lefkowitz, M.D. Biography and Interview".www.achievement.org.American Academy of Achievement.
- ^"Pioneers of cell receptor research share America's top prize in medicine".Albany Medical Center Website.
- ^"Highly Cited Research – Research Analytics – Thomson Reuters".Hcr3.webofknowledge.com. December 31, 2011.RetrievedOctober 12,2012.[permanent dead link]
- ^"A Funny Thing Happened on the Way to Stockholm".pegasusbooks.com.RetrievedMarch 31,2021.
- ^"New & Noteworthy, From Food Policy to Communicating With the Dead".The New York Times.February 2, 2021.ISSN0362-4331.RetrievedMarch 31,2021.
- ^Robinson, Andrew (March 17, 2021)."The accidental Nobel laureate, what we owe to our voices and the philosophy of touch: Books in Brief".Nature.591(7850): 364.Bibcode:2021Natur.591..364R.doi:10.1038/d41586-021-00661-4.
- ^"Golden Plate Awardees of the American Academy of Achievement".www.achievement.org.American Academy of Achievement.
- ^"Biomedicine 2009 Robert J. Lefkowitz".BBVA Foundation Frontiers of Knowledge Awards. Archived fromthe originalon March 17, 2016.RetrievedJanuary 14,2013.
- ^"North Carolina scientist wins American Heart Association award for discovering receptors' role as specific targets for drug therapy".American Heart Association.November 15, 2009.RetrievedJanuary 14,2013.
- ^"Robert Lefkowitz receiving the National Medal of Science".Duke University. September 28, 2008.Archivedfrom the original on December 21, 2021.RetrievedJanuary 14,2013.– YouTube video of the ceremony
- ^Duke Medicine News and Communications (September 28, 2008)."Duke Medicine Physician-Scientist Receives National Medal of Science".Duke Health.org.RetrievedJanuary 14,2013.
- ^"Announcement and Citation".The Shaw Prize. June 12, 2007. Archived fromthe originalon April 7, 2016.RetrievedJanuary 14,2013.
- ^"Albany Medical Center Prize".Albany Medical College.Archived fromthe originalon July 17, 2012.RetrievedJanuary 14,2013.
- ^"Fondation Lefoulon Delalande – Historique des prix".Fondation Lefoulon – Delalande.RetrievedJanuary 14,2013.
- ^"Jessie Stevenson Kovalenko Medal".National Academy of Sciences.RetrievedJanuary 14,2013.
- ^"Bristol Myers Squib Achievements".Bristol-Myers Squibb.RetrievedJanuary 14,2013.
- ^"Robert J. Lefkowitz".Gairdner.RetrievedJanuary 14,2013.
- ^"Previous Winners of Society Awards"(PDF).American Society for Pharmacology and Experimental Therapeutics.RetrievedJanuary 14,2013.
External links
edit- "Lefkowitz Lab".RetrievedJanuary 14,2013.– Web site of his lab.
- "Robert J. Lefkowitz, MD".HHMI.RetrievedFebruary 23,2024.
- Robert Lefkowitz – National Medal of ScienceonYouTube
- Robert Lefkowitzon Nobelprize.org
- Lefkowitz, Robert J. (February 2, 2021).A Funny Thing Happened on the Way to Stockholm.Pegasus Books.ISBN978-1-64313-638-7.
