Inimmunology,the termsensitizationis used for the following concepts:[1][2][3][4][5]
- Immunizationby inducing an adaptive response in the immune system.[1][2][3][4][5]In this sense, sensitization is the term more often in usage for induction ofallergic responses.[4]
- To bind antibodies to cells such aserythrocytesin advance of performing an immunological test such as acomplement-fixation testor aCoombs test.[1][2][5]The antibodies are bound to the cells in theirFab regionsin the preparation.
- To bind antibodies or soluble antigens chemically or by adsorption to appropriate biological entities such as erythrocytes or particles made ofgelatinorlatexfor passive aggregation tests.[5]
Those particles themselves are biologically inactive except for serving as antigens against theprimary antibodiesor as carriers of theantigens.[5]When antibodies are used in the preparation, they are bound to the erythrocyte or particles in their Fab regions. Thus the step follows requires the secondary antibodies against those primary antibodies, that is, the secondary antibodies must have binding specificity to the primary antibodies including to theirFc regions.
References
edit- ^abcAnderson DM, ed. (2003). "Sensitization."Dorland's Illustrated Medical Dictionary,30th ed. Philadelphia: Saunders, p. 1680.ISBN0-7216-0146-4.
- ^abcBrown MJ, ed. (1992). "Sensitization."Miller-Keane Encyclopedia & Dictionary of Medicine, Nursing, and Allied Health,5th ed. Philadelphia; London: Saunders, p. 1352.ISBN0-7216-3456-7.
- ^abPugh MB, ed. (2000). "Sensitization."Stedman's Medical Dictionary,27th ed. Philadelphia: Lippincott Williams and Wilkins, p. 1619.ISBN0-683-40007-X.
- ^abcJaneway C, Travers P, Walport M, Shlomchik M, eds. (2001).Immunobiology 5: The Immune System in Health and Disease.New York: Garland Pub.,ISBN0-8153-3642-X
- ^abcdeTada T, Taniguchi M, Okumura Y, Miyasaka M, eds. (1993). "Sensitization."Dictionary of Terms in Immunology,3rd ed. Osaka: Saishin-Igakusha, Ltd., p. 510.ISBN4-914909-10-3C3547 (in Japanese).