The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as thetetraspaninfamily. Most of these members arecell-surfaceproteins that are characterized by the presence of fourhydrophobicdomains. The proteins mediatesignal transductionevents that play a role in the regulation of cell development, activation,growthandmotility.This encoded protein is a cell surfaceglycoproteinand is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role incell proliferation,and overexpression of this protein may be associated with the uncontrolled growth oftumour cells.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer".Gene.208(1): 25–30.doi:10.1016/S0378-1119(97)00633-1.PMID9479038.
Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye".J. Cell Sci.114(Pt 23): 4143–51.doi:10.1242/jcs.114.23.4143.PMID11739647.
Lee SY, Kim YT, Lee MS, et al. (2006). "Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment".Exp. Cell Res.312(16): 2983–99.doi:10.1016/j.yexcr.2006.06.001.hdl:10371/3238.PMID16828471.
Kaneko R, Tsuji N, Kamagata C, et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa".Am. J. Gastroenterol.96(12): 3457–8.doi:10.1111/j.1572-0241.2001.05355.x.PMID11774983.S2CID31864317.
