Wikipedia

Vitiligo

For the album, seeVitiligo(album).
Not to be confused withVertigo.

Vitiligo(/ˌvɪtɪˈlaɪɡoʊ/,vi-ti-leye-goh) is achronicautoimmune disorderthat causes patches of skin to losepigmentor color.[1]The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure.[5][6]Treatment options includetopical medications,light therapy,surgeryandcosmetics.[6]The condition can show up on any skin type as a light peachy color and can appear on any place on the body in all sizes. The spots on the skin known as vitiligo are also able to “change” as spots lose and regain pigment; they will stay in relatively the same areas but can move over time and some big patches can move through the years but never disappear overnight.

Vitiligo
Non-segmental vitiligo of the hand
Pronunciation
SpecialtyDermatologyImmunology
SymptomsPatches ofwhite skin[1]
Usual onsetChildhood, young adult[1]
DurationLong term[1]
CausesUnknown[2]
Risk factorsFamily history, otherautoimmune diseases[3]
Diagnostic methodTissue biopsy[3]
TreatmentSunscreen,makeup,topicalcorticosteroids,phototherapy[2][3]
Frequency0.1-2.1%[4]

Signs and symptoms

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The only sign of vitiligo is the presence of pale patchy areas of depigmented skin which tend to occur on the extremities.[7][8]Some people may experience itching before a new patch appears.[9]The patches are initially small, but often grow and change shape.[7][10]When skinlesionsoccur, they are most prominent on the face, hands and wrists.[7][8]The loss of skin pigmentation is particularly noticeable around body orifices, such as the mouth, eyes,nostrils,genitaliaandumbilicus.[7][8]Some lesions haveincreased skin pigmentaround the edges.[11]Those affected by vitiligo who arestigmatizedfor their condition may experience depression and similarmood disorders.[12]

  • Vitiligo on lighter skin
  • Non-segmental vitiligo on dark skin
  • Non-segmental vitiligo of the eyelids

Causes

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Although multiple hypotheses have been suggested as potential triggers that cause vitiligo, studies strongly imply that changes in theimmune systemare responsible for the condition.[2][13]Vitiligo has been proposed to be amultifactorial diseasewith genetic susceptibility and environmental factors both thought to play a role.[2]It is hypothesized that damaging environmental factors can disruptredoxreactions necessary forprotein folding,so skin cells may initiate the unfolded protein response which releasescytokines,thus mounting an immune response.[14][15]

TheNational Institutes of Healthstates that sometimes an event, like asunburn,emotional distress, or exposure to a chemical, can trigger or exacerbate the condition,[16]Skin depigmentation in particular areas in vitiligo can also be triggered by mechanical trauma: this is an example of theKoebner phenomenom.[17]Unlike in other skin diseases, this can be caused by daily activities, especially chronic friction on particular areas of the body.[17]

Immune

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Melaninis the pigment that gives skin its color; it is produced by skin cells calledmelanocytes.

Variations in genes that are part of the immune system or part of melanocytes have both been associated with vitiligo.[2]It is also thought to be caused by the immune system attacking and destroying the melanocytes of the skin.[18]A genome wide association study found approximately 36 independent susceptibilitylocifor generalized vitiligo.[19]

The TYR gene encodes the proteintyrosinase,which is not a component of the immune system but is an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a majorautoantigenin generalized vitiligo.[2]

Autoimmune associations

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Vitiligo is sometimes associated withautoimmuneandinflammatory diseasessuch asHashimoto's thyroiditis,scleroderma,rheumatoid arthritis,type 1 diabetes mellitus,psoriasis,Addison's disease,pernicious anemia,alopecia areata,systemic lupus erythematosus,andceliac disease.[2][20]

Among the inflammatory products ofNLRP1arecaspase 1andcaspase 7,which activate the inflammatorycytokineinterleukin-1β.Interleukin-1β andinterleukin-18are expressed at high levels in people with vitiligo.[21]In one of the mutations, theamino acidleucine in the NALP1 protein was replaced byhistidine(Leu155 → His). The original protein and sequence is highlyconserved in evolution,and is found in humans,chimpanzees,rhesus monkeys,andbush babies.Addison's disease(typically an autoimmune destruction of theadrenal glands) may also be seen in individuals with vitiligo.[22][23]

Oxidative stress

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Numerous whole-exome sequencing studies have demonstrated that vitiligo is associated with polymorphisms in genes involved in the response to oxidative stress such as CAT, SOD1, SOD2, SOD3, NFE2L2, HMOX1, GST-M1 or GST-T1 supporting the association of elevated levels of reactive oxygen species in melanocytes with the induction of an auto-immune response.[24][25]

Thus, diseases presenting with altered mitochondrial function such as MELAS, Vogt-Koyanagi-Harada syndrome and Kabuki syndrome are associated with increased risk of vitiligo.[26][27][28]

In line with these observations, genetic alterations in mitochondrial DNA (mtDNA) of melanocytes associated with altered mitochondrial function lead to a release of mtDNA that can be detected in the skin of vitiligo patients.[29][30]This mtDNA can be sensed by the cGAS-STING pathway resulting in pro-inflammatory cytokine and chemokines production promoting the recruitment of cytotoxic CD8+ T cells. The use of mitochondrial antioxidants, NRF2 inhibitors, and TBK1 inhibitors is emerging as potential therapeutic options to block this cascade of events.[29]

Diagnosis

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UV photograph of a hand with vitiligo
UV photograph of a foot with vitiligo

Anultraviolet lightcan be used in the early phase of this disease for identification and to determine the effectiveness of treatment.[31]Using aWood's light,skin will change colour (fluoresce) when it is affected by certain bacteria, fungi, and changes to pigmentation of the skin.[32]

Classification

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Classification attempts to quantify vitiligo have been analyzed as being somewhat inconsistent,[33]while recent consensus has agreed to a system of segmental vitiligo (SV) and non-segmental vitiligo (NSV). NSV is the most common type of vitiligo.[2]

Non-segmental

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In non-segmental vitiligo (NSV), there is usually some form ofsymmetryin the location of the patches of depigmentation. New patches also appear over time and can be generalized over large portions of the body or localized to a particular area. Extreme cases of vitiligo, to the extent that little pigmented skin remains, are referred to asvitiligo universalis.NSV can come about at any age (unlike segmental vitiligo, which is far more prevalent in teenage years).[11]

Classes of non-segmental vitiligo include the following:

  • Generalized vitiligo: the most common pattern, wide and randomly distributed areas of depigmentation[34]
  • Universal vitiligo: depigmentation encompasses most of the body[34]
  • Focal vitiligo: one or a few scattered macules in one area, most common in children[34]
  • Acrofacial vitiligo: fingers and periorificial areas[34]
  • Mucosal vitiligo: depigmentation of only the mucous membranes[34]

Segmental

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Segmental vitiligo (SV) differs in appearance, cause, and frequency of associated illnesses. Its treatment is different from that of NSV. It tends to affect areas of skin that are associated withdorsal rootsfrom thespinal cordand is most often unilateral.[2][35]It is much more stable/static in its course and its association with autoimmune diseases appears to be weaker than that of generalized vitiligo.[35]SV does not improve with topical therapies or UV light; however, surgical treatments such as cellular grafting can be effective.[11]

Differential diagnosis

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Chemical leukoderma is a similar condition due to multiple exposures to chemicals.[1]Vitiligo however is a risk factor.[1]Triggers may include inflammatory skin conditions, burns, intralesional steroid injections, and abrasions.[1]

Other conditions with similar symptoms include the following:

Treatment

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There is no cure for vitiligo but several treatment options are available.[2]The best evidence is for appliedsteroidsandultraviolet lightin combination with creams.[36]Due to the higher risks of skin cancer, the United Kingdom'sNational Health Servicesuggests phototherapy be used only if primary treatments are ineffective.[37]Lesions located on the hands, feet, and joints are the most difficult to repigment; those on the face are easiest to return to the natural skin color as the skin is thinner.[2]

Immune mediators

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Topical preparations of immune-suppressing medications includingglucocorticoids(such as 0.05% clobetasol or 0.10% betamethasone) andcalcineurin inhibitors(such astacrolimusorpimecrolimus) are considered to be first-line vitiligo treatments.[2]

In July 2022,ruxolitinibcream (sold under the brand name Opzelura) was approved for medical use in the United States for the treatment of vitiligo.[38]

Phototherapy

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Phototherapy is considered a second-line treatment for vitiligo.[2]Exposing the skin to light from UVB lamps is the most common treatment for vitiligo. The treatments can be done at home with a UVB lamp or in a clinic. The exposure time is managed so that the skin does not suffer overexposure. Treatment can take a few weeks if the spots are on the neck and face and if they existed not more than 3 years. If the spots are on the hands and legs and have been there for more than 3 years, it can take a few months. Phototherapy sessions are done 2–3 times a week. Spots on a large area of the body may require full-body treatment in a clinic or hospital. UVB broadband and narrowband lamps can be used,[39][40]but narrowband ultraviolet peaked around 311 nm is the choice. It has been constitutively reported that a combination of UVB phototherapy with other topical treatments improves re-pigmentation. However, some people with vitiligo may not see any changes to skin or re-pigmentation occurring. A serious potential side effect involves the risk of developing skin cancer, the same risk as an overexposure to natural sunlight.[citation needed]

Ultraviolet light (UVA) treatments are normally carried out in a hospital clinic.Psoralenand ultraviolet A light (PUVA) treatment involves taking a drug that increases the skin's sensitivity to ultraviolet light and then exposing the skin to high doses of UVA light. Treatment is required twice a week for 6–12 months or longer. Because of the high doses of UVA and psoralen, PUVA may cause side effects such as sunburn-type reactions or skin freckling.[37]

Narrowband ultraviolet B (NBUVB) phototherapy lacks the side effects caused by psoralens and is as effective as PUVA.[2]As with PUVA, treatment is carried out twice weekly in a clinic or every day at home, and there is no need to use psoralen.[37]Longer treatment is often recommended, and at least 6 months may be required for effects to phototherapy.[41]NBUVB phototherapy appears better than PUVA therapy with the most effective response on the face and neck.[41]

With respect to improved repigmentation: topical calcineurin inhibitors plus phototherapy are better than phototherapy alone,[42]hydrocortisoneplus laser light is better than laser light alone,ginkgo bilobais better thanplacebo,and oral mini-pulse ofprednisolone(OMP) plus NB-UVB is better than OMP alone.[9]

Skin camouflage

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In mild cases, vitiligo patches can be hidden with makeup or othercosmetic camouflagesolutions. If the affected person is pale-skinned, the patches can be made less visible by avoidingtanningof unaffected skin.[34]

Depigmenting

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In cases of extensive vitiligo the option to depigment the unaffected skin with topical drugs likemonobenzone,mequinol,orhydroquinonemay be considered to render the skin an even color. The removal of all the skin pigment withmonobenzoneis permanent and vigorous. Sun safety must be adhered to for life to avoid severesunburnandmelanomas.Depigmentation takes about a year to complete.[37]

History

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Descriptions of a disease believed to be vitiligo date back to a passage in the medical textEbers Papyrusc. 1500 BCin ancientEgypt.Also, theHebrewword "Tzaraath"from theOld Testamentbook ofLeviticus[43]dating to 1280 BC[44](or 1312 BC[45]) described a group of skin diseases associated with white spots, and a subsequent translation to Greek led to continued conflation of those with vitiligo withleprosyand spiritual uncleanliness.[43]

Medical sources in the ancient world such asHippocratesoften did not differentiate between vitiligo and leprosy, often grouping these diseases together. The name "vitiligo" was first used by the Roman physicianAulus Cornelius Celsusin his classic medical textDe Medicina.[43]

The termvitiligois believed to be derived from "vitium", meaning "defect" or "blemish".[43]

Winnie Harlow

Society and culture

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The change in appearance caused by vitiligo can affect a person's emotional and psychological well-being and may create difficulty in becoming or remaining employed, particularly if vitiligo develops on visible areas of the body, such as the face, hands or arms. Participating in a vitiligo support group may improve social coping skills and emotional resilience.[46]

Notable people with vitiligo

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Notable cases include American pop singerMichael Jackson,[47]Canadian fashion modelWinnie Harlow,[48]New Zealand singer-songwriterKimbra,[49]American actorDavid Dastmalchianand Argentine musicianCharly García.Professional wrestlerBryan Danielson[50]and French actorMichaël Younare also affected,[51]as is former French Prime MinisterÉdouard Philippe,[52]Miss Universe Egypt 2024Logina Salah,[53]formerRoman Catholicpriest,Governor of Pampangaand TV hostEddie Panlilio,and model and formerMiss Colombia 2007Taliana Vargas.[54][55]

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The Adult Swim animated sitcomThe Boondockssatirizes the idea of vitiligo inUncle Ruckus,one of the show's characters. Ruckus, who is black, frequently claims to be white, often stating that he has "Re-vitiligo, the opposite of what Michael Jackson had." He frequently uses this argument to maintain that he is actually white, leading him to commit delusional and racist antics in nearly every episode.[56]

Research

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As of July 2013,afamelanotideis in phase II and III clinical trials for vitiligo and other skin diseases.[57]

A medication for rheumatoid arthritis,tofacitinib,has been tested for the treatment of vitiligo.[58]

In October 1992, a scientific report was published of successfully transplantingmelanocytesto vitiligo-affected areas, effectively repigmenting the region.[59]The procedure involved taking a thin layer of pigmented skin from the person'sglutealregion. Melanocytes were then separated out to acellularsuspension that was expanded in culture. The area to be treated was then denuded with adermabraderand the melanocytesgraftapplied. Between 70 and 85 percent of people with vitiligo experienced nearly complete repigmentation of their skin. The longevity of the repigmentation differed from person to person.[60]

Current research suggests that the Janus kinase/signal transducer and activator of the transcription pathway (JAK/STAT pathway) plays a crucial role in the loss of epidermal melanocytes. This pathway is activated by CXCR3+ CD8+ T cells, creating a positive feedback loop with interferon-gamma (IFN-γ) chemokines from keratinocytes, potentially contributing to vitiligo.[61]JAK inhibitors like ruxolitinib show promise in targeting the IFN-γ-chemokine signaling axis implicated in vitiligo pathogenesis, and improving nonsegmental vitiligo.[61][62][63]

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