Aaron Ciechanover

Aaron Ciechanover
ForMem, NAS
Aaron Ciechanover ForMem, NAS
	Ciechanover in 2014
Born	October 1, 1947(age 77); Haifa,Mandatory Palestine(nowIsrael)
Alma mater	Hebrew University of Jerusalem(MS, MD); Technion – Israel Institute of Technology(D.Sc)
Known for	Ubiquitin-mediatedprotein degradation
Spouse	Menucha Ciechanover
Awards	Nobel Prize in Chemistry(2004)
	Scientific career
Fields	Biology
Institutions	Technion, Israel; NCKU, Taiwan

Aaron Ciechanover(/ɑːhəˈroʊntʃiˈhɑːnoʊvɛər/^ⓘAH-hə-ROHNchee-HAH-noh-vair;Hebrew:אהרן צ'חנובר;born October 1, 1947) is an Israelibiologistwho won theNobel Prize in Chemistryfor characterizing the method that cells use to degrade and recycle proteins usingubiquitin.

Biography

Early life

Ciechanover was born inHaifa, British Mandate of Palestineon 1 October 1947^[1]into aJewishfamily.^[2]He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker in a law firm.^[3]His parents immigrated to Israel from Poland in the 1920s.

Education

He earned a master's degree in science in 1971 and graduated fromHadassah Medical SchoolinJerusalemin 1974. He received his doctorate in biochemistry in 1981 from theTechnion – Israel Institute of Technologyin Haifa before conducting postdoctoral research in the laboratory ofHarvey Lodishat theWhitehead InstituteatMITfrom 1981 to 1984.^[3]

Recent

Ciechanover is currently a Technion Distinguished Research Professor in theRuth and Bruce Rappaport Faculty of Medicineand Research Institute at the Technion. He is a member of theIsrael Academy of Sciences and Humanities,thePontifical Academy of Sciences,theNational Academy of Sciences of Ukraine,theRussian Academy of Sciencesand is a foreign associate of theUnited States National Academy of Sciences.In 2008, he was a visiting Distinguished Chair Professor atNCKU, Taiwan.As part of Shenzhen's 13th Five-Year Plan funding research in emerging technologies and opening "Nobel laureate research labs", in 2018 he opened the Ciechanover Institute of Precision and Regenerative Medicine at theChinese University of Hong Kong, Shenzhencampus.^[4]

Nobel Prize

Ciechanover is one of Israel's firstNobel Laureatesin science, earning his Nobel Prize in 2004 for his work in ubiquitination. He is honored for playing a central role in the history of Israel and in thehistory of the Technion – Israel Institute of Technology.^[5]

Publications and lectures

Ciehanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105. (His name was wrongly transliterated from Hebrew in this publication.)
Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
Hershko, A. and Ciechanover, A. (1998). THE UBIQUITIN SYSTEM. Biochem. 1998 67:1, 425–479
Ciechanover was an invited guest lecturer at the Yerevan State Medical University in Armenia in 2010.
He lectured at the Pyongyang University of Science and Technology in North Korea in May 2016.

Industry involvement

Ciechanover has served on the scientific advisory boards of the following companies:Rosetta Genomics(Chairman),BioLineRx, Ltd,StemRad, Ltd,Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd,Protalix BioTherapeutics,BioTheryX, Inc., and Haplogen, GmbH.^[6]

Ciechanover is a member of the advisory board ofPatient Innovation,a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.

Awards

In 2000, Ciechanover received theAlbert Lasker Award for Basic Medical Research.
In 2003, he was awarded theIsrael Prize,for biology.^[7]^[8]
In 2004, he was awarded theNobel PrizeinChemistryfor his discovery withAvram HershkoandIrwin Rose,ofubiquitin-mediatedprotein degradation.^[9]^[10]The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of cancer, muscular and neurological diseases, and immune and inflammatory responses.
In 2005, he received the Golden Plate Award of theAmerican Academy of Achievement.^[11]
In 2006, he was awarded theSir Hans Krebs Medal.^[12]
In 2008. he was conferred Hon. DSc by NCKU Taiwan^[13]
In 2009, he was conferred an Honorary Doctorate in Science by theUniversity of Cambodia.^[14]
In 2011, he was awarded theHumboldt Prizeof theAlexander von Humboldt Foundation.^[15]
In 2016, he became a member of theGerman Academy of Sciences Leopoldina.^[16]

References

^"Irwin Rose | American biochemist".Encyclopædia Britannica.Retrieved2020-04-05.
^JINFO."Jewish Nobel Prize Winners in Chemistry".jinfo.org.Retrieved2023-03-30.
^^a ^b"The Nobel Prize in Chemistry 2004".NobelPrize.org.Retrieved2024-05-12.
^"Ciechanover Institute of Precision and Regenerative Medicine Established | CUHK-Shenzhen".cuhk.edu.cn.Retrieved2021-03-20.
^"The Nobel Prize in Chemistry 2004".NobelPrize.org.Retrieved2021-04-23.
^"Haplogen – Scientific Advisory Board".Archived fromthe originalon 2021-04-16.Retrieved2019-02-14.
^"Israel Prize Official Site (in Hebrew) – Recipient's C.V."
^"Israel Prize Official Site (in Hebrew) – Judges' Rationale for Grant to Recipient".^{[permanent dead link]}
^Aaron Ciechanoveron Nobelprize.org
^Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry Archived2005-12-19 at theWayback Machine– A web article
^"Golden Plate Awardees of the American Academy of Achievement".achievement.org.American Academy of Achievement.
^"Sir Hans Krebs Medal to Harald Stenmark".Oslo University Hospital.Retrieved16 December2014.
^"NCKU honors world class scientists, 2008".Archived fromthe originalon 2020-07-27.Retrieved2020-05-26.
^"Welcome to The University of Cambodia (UC)".uc.edu.kh.Retrieved2018-05-09.
^"Humboldt-Forschungspreis für Nobelpreisträger Aaron Ciechanover".Retrieved14 Feb2023.
^"Aaron Ciechanover".German Academy of Sciences Leopoldina.Retrieved26 May2021.

External links

Scholiahas anauthorprofile forAaron Ciechanover.

Aaron Ciechanoveron Nobelprize.orgincluding the Nobel Lecture on December 8, 2004Intracellular Protein Degradation: From a Vague Idea thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting
Website at the Technion
A video interview with Aaron Ciechanover
[1]

[1] "Irwin Rose | American biochemist".Encyclopædia Britannica.Retrieved2020-04-05.

[2] JINFO."Jewish Nobel Prize Winners in Chemistry".jinfo.org.Retrieved2023-03-30.

[:0-3] "The Nobel Prize in Chemistry 2004".NobelPrize.org.Retrieved2024-05-12.

[4] "Ciechanover Institute of Precision and Regenerative Medicine Established | CUHK-Shenzhen".cuhk.edu.cn.Retrieved2021-03-20.

[5] "The Nobel Prize in Chemistry 2004".NobelPrize.org.Retrieved2021-04-23.

[6] "Haplogen – Scientific Advisory Board".Archived fromthe originalon 2021-04-16.Retrieved2019-02-14.

[7] "Israel Prize Official Site (in Hebrew) – Recipient's C.V."

[8] "Israel Prize Official Site (in Hebrew) – Judges' Rationale for Grant to Recipient".^{[permanent dead link]}

[9] Aaron Ciechanoveron Nobelprize.org

[10] Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry Archived2005-12-19 at theWayback Machine– A web article

[11] "Golden Plate Awardees of the American Academy of Achievement".achievement.org.American Academy of Achievement.

[12] "Sir Hans Krebs Medal to Harald Stenmark".Oslo University Hospital.Retrieved16 December2014.

[13] "NCKU honors world class scientists, 2008".Archived fromthe originalon 2020-07-27.Retrieved2020-05-26.

[14] "Welcome to The University of Cambodia (UC)".uc.edu.kh.Retrieved2018-05-09.

[15] "Humboldt-Forschungspreis für Nobelpreisträger Aaron Ciechanover".Retrieved14 Feb2023.

[16] "Aaron Ciechanover".German Academy of Sciences Leopoldina.Retrieved26 May2021.

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