CXCL7

Chemokine (C-X-C motif) ligand 7(CXCL7) is a humangene.

PPBP
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 1TVX,1F9P,1NAP
Identifiers
Aliases	PPBP,B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
External IDs	OMIM:121010;MGI:1888712;HomoloGene:136759;GeneCards:PPBP;OMA:PPBP - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.3 Start 73,986,439bp End 73,988,190bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E1 Start 90,916,377bp End 90,917,922bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in monocyte trabecular bone granulocyte blood bone marrow cells periodontal fiber spleen decidua right lung testicle Top expressed in tibiofemoral joint umbilical cord blood spleen fetal liver hematopoietic progenitor cell body of femur right lung lobe human fetus endocardial cushion yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity cytokine activity glucose transmembrane transporter activity CXCR chemokine receptor binding chemokine activity protein binding Cellular component platelet Alpha granule lumen extracellular region extracellular space tertiary granule lumen platelet Alpha granule Biological process response to lipopolysaccharide regulation of cell population proliferation chemotaxis positive regulation of cell division platelet degranulation defense response to bacterium inflammatory response immune response chemokine-mediated signaling pathway defense response positive regulation of neutrophil chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity neutrophil degranulation cell chemotaxis G protein-coupled receptor signaling pathway glucose transmembrane transport neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharide Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 5473 57349 Ensembl ENSG00000163736 ENSMUSG00000029372 UniProt P02775 Q9EQI5 RefSeq (mRNA) NM_002704 NM_023785 RefSeq (protein) NP_002695 NP_076274 Location (UCSC) Chr 4: 73.99 – 73.99 Mb Chr 5: 90.92 – 90.92 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

The encoded protein,Chemokine (C-X-C motif) ligandis a smallcytokinebelonging to the CXCchemokinefamily. It is an isoform ofBeta-ThromboglobulinorPro-Platelet basic protein(PPBP).

It is a protein that is released in large amounts fromplateletsfollowing their activation.It stimulates various processes includingmitogenesis,synthesis ofextracellular matrix,glucose metabolismand synthesis ofplasminogen activator.

Further reading

• Begg GS, Pepper DS, Chesterman CN, Morgan FJ (1978). "Complete covalent structure of human beta-thromboglobulin".Biochemistry.17(9): 1739–44.doi:10.1021/bi00602a024.PMID77677.
• Kaplan KL, Broekman MJ, Chernoff A, et al. (1979)."Platelet Alpha -granule proteins: studies on release and subcellular localization".Blood.53(4): 604–18.doi:10.1182/blood.V53.4.604.604.PMID426909.
• Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992)."Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4".Blood.79(11): 2896–900.doi:10.1182/blood.V79.11.2896.2896.PMID1316786.
• Cohen AB, Stevens MD, Miller EJ, et al. (1992). "Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets".Am. J. Physiol.263(2 Pt 1): L249–56.doi:10.1152/ajplung.1992.263.2.L249.PMID1387511.
• Morris SW, Nelson N, Valentine MB, et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35".Genomics.14(3): 685–91.doi:10.1016/S0888-7543(05)80169-7.PMID1427896.
• Majumdar S, Gonder D, Koutsis B, Poncz M (1991)."Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4".J. Biol. Chem.266(9): 5785–9.doi:10.1016/S0021-9258(19)67665-9.PMID1826003.
• Wenger RH, Hameister H, Clemetson KJ (1991). "Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily".Hum. Genet.87(3): 367–8.doi:10.1007/BF00200921.PMID1830861.S2CID19420329.
• Hjemdahl P, Perneby C, Theodorsson E, et al. (1992). "A new assay for beta-thromboglobulin in urine".Thromb. Res.64(1): 33–43.doi:10.1016/0049-3848(91)90203-9.PMID1837963.
• Brandt E, Van Damme J, Flad HD (1991). "Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III".Cytokine.3(4): 311–21.doi:10.1016/1043-4666(91)90499-4.PMID1873479.
• Clark-Lewis I, Moser B, Walz A, et al. (1991). "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide".Biochemistry.30(12): 3128–35.doi:10.1021/bi00226a021.PMID2007144.
• Walz A, Baggiolini M (1990)."Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases".J. Exp. Med.171(2): 449–54.doi:10.1084/jem.171.2.449.PMC2187709.PMID2406364.
• Holt JC, Harris ME, Holt AM, et al. (1986). "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin".Biochemistry.25(8): 1988–96.doi:10.1021/bi00356a023.PMID2423119.
• Walz A, Baggiolini M (1989). "A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils".Biochem. Biophys. Res. Commun.159(3): 969–75.doi:10.1016/0006-291X(89)92203-1.PMID2522778.
• Wenger RH, Wicki AN, Walz A, et al. (1989)."Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library".Blood.73(6): 1498–503.doi:10.1182/blood.V73.6.1498.1498.PMID2713489.
• Castor CW, Walz DA, Ragsdale CG, et al. (1989). "Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets".Biochem. Biophys. Res. Commun.163(2): 1071–8.doi:10.1016/0006-291X(89)92330-9.PMID2783111.
• Holt JC, Rabellino EM, Gewirtz AM, et al. (1988). "Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes".Exp. Hematol.16(4): 302–6.PMID2966071.
• Castor CW, Furlong AM, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III".Biochemistry.24(7): 1762–7.doi:10.1021/bi00328a029.PMID4005226.
• McLaren KM, Pepper DS (1983)."Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets".J. Clin. Pathol.35(11): 1227–31.doi:10.1136/jcp.35.11.1227.PMC497932.PMID6183294.
• Castor CW, Miller JW, Walz DA (1983)."Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor".Proc. Natl. Acad. Sci. U.S.A.80(3): 765–9.Bibcode:1983PNAS...80..765C.doi:10.1073/pnas.80.3.765.PMC393460.PMID6572368.
• Malkowski MG, Wu JY, Lazar JB, et al. (1995)."The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution".J. Biol. Chem.270(13): 7077–87.doi:10.1074/jbc.270.13.7077.PMID7706245.

External links

• HumanPPBPgenome location andPPBPgene details page in theUCSC Genome Browser.