Decorinis aproteinthat in humans is encoded by theDCNgene.
Decorin is aproteoglycanthat is on average 90 - 140kilodaltons(kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containingleucine repeatswith aglycosaminoglycan(GAG) chain consisting of eitherchondroitin sulfate(CS) ordermatan sulfate(DS).
Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure tobiglycanprotein. Decorin and biglycan are thought to be the result of agene duplication.This protein is a component ofconnective tissue,binds totype I collagenfibrils,and plays a role inmatrixassembly.[5]
Naming
editDecorin's name is a derivative of both the fact that it "decorates"collagen type I,and that it interacts with the "d" and "e" bands of fibrils of this collagen.
Function
editDecorin appears to influencefibrillogenesis,and also interacts withfibronectin,thrombospondin,thecomplement component C1q,epidermal growth factor receptor(EGFR) and transforming growth factor-beta (TGF-beta).
Decorin has been shown to either enhance or inhibit the activity ofTGF-beta 1.The primary function of decorin involves regulation during thecell cycle.
It has been involved in the regulation ofautophagy,ofendothelial celland inhibitsangiogenesis.This process is mediated by a high-affinity interaction withVEGFR2(vascular endothelial growth factor receptor) which leads to increased levels of tumor suppressor gene calledPEG3.[6]Other angiogenic growth factors that decorin inhibits areangiopoietin,hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF).[7]
Decorin has recently been established as amyokine.In this role, it promotes musclehypertrophyby binding withmyostatin.[8]
Clinical significance
editKeloid scarshave decreased decorin expression compared to healthyskin.[9]Development ofcongenital stromal corneal dystrophyis dependent on export and extracellular deposition of truncated decorin.[10]
Animal studies
editInfusion of decorin into experimental rodent spinal cord injuries has been shown to suppress scar formation and promote axon growth.
Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines.[11]The decorin-deficientknockout mouseshows reduced inflammatory reactions duringcontact dermatitisdue to a defect inleukocyterecruitment and alteredinterferon gammafunction.[12][13]
Interactions
editDecorin has been shown tointeractwith:
References
edit- ^abcGRCh38: Ensembl release 89: ENSG00000011465–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000019929–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Entrez Gene: DCN decorin".
- ^Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens RT, et al. (July 2013)."Decorin causes autophagy in endothelial cells via Peg3".Proceedings of the National Academy of Sciences of the United States of America.110(28): E2582-91.Bibcode:2013PNAS..110E2582B.doi:10.1073/pnas.1305732110.PMC3710796.PMID23798385.
- ^Järveläinen H, Sainio A, Wight TN (April 2015)."Pivotal role for decorin in angiogenesis".Matrix Biology.43:15–26.doi:10.1016/j.matbio.2015.01.023.PMC4560244.PMID25661523.
- ^Kanzleiter T, Rath M, Görgens SW, Jensen J, Tangen DS, Kolnes AJ, et al. (July 2014). "The myokine decorin is regulated by contraction and involved in muscle hypertrophy".Biochemical and Biophysical Research Communications.450(2):1089–94.doi:10.1016/j.bbrc.2014.06.123.PMID24996176.
- ^Jumper N, Paus R, Bayat A (September 2015). "Functional histopathology of keloid disease".Histology and Histopathology.30(9):1033–57.doi:10.14670/HH-11-624.PMID25900252.
- ^Mellgren AE, Bruland O, Vedeler A, Saraste J, Schönheit J, Bredrup C, et al. (May 2015). "Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin".Investigative Ophthalmology & Visual Science.56(5):2909–15.doi:10.1167/iovs.14-16014.PMID26029887.
- ^Sofeu Feugaing DD, Götte M, Viola M (January 2013). "More than matrix: the multifaceted role of decorin in cancer".European Journal of Cell Biology.92(1):1–11.doi:10.1016/j.ejcb.2012.08.004.PMID23058688.
- ^Seidler DG, Mohamed NA, Bocian C, Stadtmann A, Hermann S, Schäfers K, et al. (December 2011)."The role for decorin in delayed-type hypersensitivity".Journal of Immunology.187(11):6108–19.doi:10.4049/jimmunol.1100373.PMC5070385.PMID22043007.
- ^Bocian C, Urbanowitz AK, Owens RT, Iozzo RV, Götte M, Seidler DG (May 2013)."Decorin potentiates interferon-γ activity in a model of allergic inflammation".The Journal of Biological Chemistry.288(18):12699–711.doi:10.1074/jbc.M112.419366.PMC3642316.PMID23460644.
- ^abSchönherr E, Broszat M, Brandan E, Bruckner P, Kresse H (July 1998). "Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen".Archives of Biochemistry and Biophysics.355(2):241–8.doi:10.1006/abbi.1998.0720.PMID9675033.
- ^Santra M, Reed CC, Iozzo RV (September 2002)."Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope".The Journal of Biological Chemistry.277(38):35671–81.doi:10.1074/jbc.M205317200.PMID12105206.S2CID20575381.
- ^Iozzo RV, Moscatello DK, McQuillan DJ, Eichstetter I (February 1999)."Decorin is a biological ligand for the epidermal growth factor receptor".The Journal of Biological Chemistry.274(8):4489–92.doi:10.1074/jbc.274.8.4489.PMID9988678.S2CID32175802.
- ^Hildebrand A, Romarís M, Rasmussen LM, Heinegård D, Twardzik DR, Border WA, Ruoslahti E (September 1994)."Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta".The Biochemical Journal.302 ( Pt 2) (2):527–34.doi:10.1042/bj3020527.PMC1137259.PMID8093006.
- ^Takeuchi Y, Kodama Y, Matsumoto T (December 1994)."Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity".The Journal of Biological Chemistry.269(51):32634–8.doi:10.1016/S0021-9258(18)31681-8.PMID7798269.
- ^abMerline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhão JG, et al. (November 2011)."Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21".Science Signaling.4(199): ra75.doi:10.1126/scisignal.2001868.PMC5029092.PMID22087031.
Further reading
edit- Ständer M, Naumann U, Wick W, Weller M (May 1999). "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth".Cell and Tissue Research.296(2):221–7.doi:10.1007/s004410051283.PMID10382266.S2CID20282995.
- Fujisawa R (March 2002). "[Recent advances in research on bone matrix proteins]".Nihon Rinsho. Japanese Journal of Clinical Medicine.60(Suppl 3):72–8.PMID11979972.
- Krumdieck R, Höök M, Rosenberg LC, Volanakis JE (December 1992)."The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex".Journal of Immunology.149(11):3695–701.doi:10.4049/jimmunol.149.11.3695.PMID1431141.S2CID23005992.
- Winnemöller M, Schön P, Vischer P, Kresse H (October 1992). "Interactions between thrombospondin and the small proteoglycan decorin: interference with cell attachment".European Journal of Cell Biology.59(1):47–55.PMID1468447.
- Murphy-Ullrich JE, Schultz-Cherry S, Höök M (February 1992)."Transforming growth factor-beta complexes with thrombospondin".Molecular Biology of the Cell.3(2):181–8.doi:10.1091/mbc.3.2.181.PMC275517.PMID1550960.
- Pulkkinen L, Alitalo T, Krusius T, Peltonen L (1992). "Expression of decorin in human tissues and cell lines and defined chromosomal assignment of the gene locus (DCN)".Cytogenetics and Cell Genetics.60(2):107–11.doi:10.1159/000133314.PMID1611907.
- McBride OW, Fisher LW, Young MF (February 1990)."Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human chromosomes Xq13-qter and 12q, respectively".Genomics.6(2):219–25.doi:10.1016/0888-7543(90)90560-H.PMID1968422.
- Fleischmajer R, Fisher LW, MacDonald ED, Jacobs L, Perlish JS, Termine JD (February 1991)."Decorin interacts with fibrillar collagen of embryonic and adult human skin".Journal of Structural Biology.106(1):82–90.doi:10.1016/1047-8477(91)90065-5.PMID2059554.
- Pulkkinen L, Kainulainen K, Krusius T, Mäkinen P, Schollin J, Gustavsson KH, Peltonen L (October 1990)."Deficient expression of the gene coding for decorin in a lethal form of Marfan syndrome".The Journal of Biological Chemistry.265(29):17780–5.doi:10.1016/S0021-9258(18)38231-0.PMID2211661.
- Yamaguchi Y, Mann DM, Ruoslahti E (July 1990). "Negative regulation of transforming growth factor-beta by the proteoglycan decorin".Nature.346(6281):281–4.Bibcode:1990Natur.346..281Y.doi:10.1038/346281a0.PMID2374594.S2CID4272333.
- Greve H, Blumberg P, Schmidt G, Schlumberger W, Rauterberg J, Kresse H (July 1990)."Influence of collagen lattice on the metabolism of small proteoglycan II by cultured fibroblasts".The Biochemical Journal.269(1):149–55.doi:10.1042/bj2690149.PMC1131544.PMID2375748.
- Roughley PJ, White RJ (September 1989)."Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II".The Biochemical Journal.262(3):823–7.doi:10.1042/bj2620823.PMC1133347.PMID2590169.
- Fisher LW, Termine JD, Young MF (March 1989)."Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species".The Journal of Biological Chemistry.264(8):4571–6.doi:10.1016/S0021-9258(18)83781-4.PMID2647739.
- Yamaguchi Y, Ruoslahti E (November 1988). "Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation".Nature.336(6196):244–6.Bibcode:1988Natur.336..244Y.doi:10.1038/336244a0.PMID3194009.S2CID4338095.
- Krusius T, Ruoslahti E (October 1986)."Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA".Proceedings of the National Academy of Sciences of the United States of America.83(20):7683–7.Bibcode:1986PNAS...83.7683K.doi:10.1073/pnas.83.20.7683.PMC386785.PMID3484330.
- Fisher LW, Hawkins GR, Tuross N, Termine JD (July 1987)."Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone".The Journal of Biological Chemistry.262(20):9702–8.doi:10.1016/S0021-9258(18)47991-4.PMID3597437.
- Lysiak JJ, Hunt J, Pringle GA, Lala PK (April 1995). "Localization of transforming growth factor beta and its natural inhibitor decorin in the human placenta and decidua throughout gestation".Placenta.16(3):221–31.doi:10.1016/0143-4004(95)90110-8.PMID7638106.
- Takeuchi Y, Kodama Y, Matsumoto T (December 1994)."Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity".The Journal of Biological Chemistry.269(51):32634–8.doi:10.1016/S0021-9258(18)31681-8.PMID7798269.
- Scholzen T, Solursh M, Suzuki S, Reiter R, Morgan JL, Buchberg AM, et al. (November 1994)."The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation".The Journal of Biological Chemistry.269(45):28270–81.doi:10.1016/S0021-9258(18)46924-4.PMID7961765.
- Danielson KG, Fazzio A, Cohen I, Cannizzaro LA, Eichstetter I, Iozzo RV (January 1993). "The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23".Genomics.15(1):146–60.doi:10.1006/geno.1993.1022.PMID8432526.
- Bredrup C, Knappskog PM, Majewski J, Rødahl E, Boman H (February 2005). "Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene".Investigative Ophthalmology & Visual Science.46(2):420–6.doi:10.1167/iovs.04-0804.PMID15671264.