Expasyis an onlinebioinformaticsresource operated by theSIB Swiss Institute of Bioinformatics.It is anextensibleandintegrativeportal which provides access to over 160 databases and software tools and supports a range of life science and clinical research areas, fromgenomics,proteomicsandstructural biology,toevolutionandphylogeny,systems biologyandmedical chemistry.The individual resources (databases, web-based and downloadable software tools) are hosted in a decentralized way by different groups of the SIB Swiss Institute of Bioinformatics and partner institutions.
Search engine
editQueries of Expasy allow:
- parallel searches SIB databases through a single search
- aggregated search results from the complete set of >160 resources accessible from the portal.[1]
Expasy provides up-to-date information from the most recent release of each resources.
The terms used in Expasy are based on the EDAM comprehensiveontology.[2]
History
editExpasy was created in August 1993. Originally, it was calledExPASy(ExpertProteinAnalysisSystem) and acted as aproteomicsserver to analyzeproteinsequences and structures andtwo-dimensional gel electrophoresis(2-D Page electrophoresis).[3]Among others, ExPASy hosted the protein sequence knowledge base,UniProtKB/Swiss-Prot,and its computer annotated supplement, UniProtKB/TrEMBL.[4]
ExPASy was thefirst websiteof thelife sciencesand among the first 150 websites in the world. As of 5 April 2007[update],ExPASy had been consulted 1 billion times since its installation on 1 August 1993.[5]
In June 2011, it became the SIB ExPASy Bioinformatics Resources Portal: a diverse catalogue of bioinformatics resources developed by SIB Groups.[6]The current version of Expasy was released in October 2020.[7][8]
Notes and references
edit- ^"SIB Resources".sib.swiss.Retrieved27 October2020.
- ^Ison J, Kalas M, Jonassen I, Bolser D, Uludag M, McWilliam H, et al. (May 2013)."EDAM: an ontology of bioinformatics operations, types of data and identifiers, topics and formats".Bioinformatics.29(10): 1325–32.doi:10.1093/bioinformatics/btt113.PMC3654706.PMID23479348.
- ^Gasteiger E, Gattiker A, Hoogland C, Ivanyi I, Appel RD, Bairoch A (July 2003)."ExPASy: The proteomics server for in-depth protein knowledge and analysis".Nucleic Acids Research.31(13): 3784–8.doi:10.1093/nar/gkg563.PMC168970.PMID12824418.
- ^"UniProtKB/Swiss-Prot - SIB Swiss Institute of Bioinformatics | Expasy".expasy.org.Retrieved15 March2024.
- ^ExPASy: SIB Bioinformatics Resource Portal
- ^Artimo P, Jonnalagedda M, Arnold K, Baratin D, Csardi G, de Castro E, et al. (July 2012)."ExPASy: SIB bioinformatics resource portal".Nucleic Acids Research.40(Web Server issue): W597-603.doi:10.1093/nar/gks400.PMC3394269.PMID22661580.
- ^Duvaud, Séverine; Gabella, Chiara; Lisacek, Frédérique; Stockinger, Heinz; Ioannidis, Vassilios; Durinx, Christine (13 April 2021)."Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users".Nucleic Acids Research.49(W1): W216–W227.doi:10.1093/nar/gkab225.ISSN0305-1048.PMC8265094.PMID33849055.
- ^"Discover the new Expasy.org, the Swiss Bioinformatics Resource Portal".sib.swiss.Retrieved26 October2020.