Protocadherin Fat 4,also known ascadherin family member 14(CDHF14) orFAT tumor suppressor homolog 4(FAT4), is aproteinthat in humans is encoded by theFAT4gene.[5][6]
FAT4 is associated with theHippo signaling pathway.[7]
Clinical significance
editMutations in FAT4 are associated toHennekam syndrome.[8]
References
edit- ^abcGRCh38: Ensembl release 89: ENSG00000196159–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000046743–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)".
- ^Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods".J. Mol. Biol.337(2): 307–17.doi:10.1016/j.jmb.2004.01.026.PMID15003449.
- ^Qi C, Zhu YT, Hu L, Zhu YJ (February 2009)."Identification of Fat4 as a candidate tumor suppressor gene in breast cancers".Int. J. Cancer.124(4): 793–8.doi:10.1002/ijc.23775.PMC2667156.PMID19048595.
- ^Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome".Human Genetics.133(9): 1161–1167.doi:10.1007/s00439-014-1456-y.PMID24913602.S2CID14414158.
Further reading
edit- Katoh Y, Katoh M (2006)."Comparative integromics on FAT1, FAT2, FAT3 and FAT4".Int. J. Mol. Med.18(3): 523–8.doi:10.3892/ijmm.18.3.523.PMID16865240.
- Caporaso N, Gu F, Chatterjee N, et al. (2009). Reitsma PH (ed.)."Genome-wide and candidate gene association study of cigarette smoking behaviors".PLOS ONE.4(2): e4653.Bibcode:2009PLoSO...4.4653C.doi:10.1371/journal.pone.0004653.PMC2644817.PMID19247474.
- Liu Y, Blackwood DH, Caesar S, et al. (2010)."Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder".Molecular Psychiatry.16(1): 2–4.doi:10.1038/mp.2009.107.PMC3883627.PMID20351715.
- Need AC, Attix DK, McEvoy JM, et al. (2009)."A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB".Hum. Mol. Genet.18(23): 4650–61.doi:10.1093/hmg/ddp413.PMC2773267.PMID19734545.
- Rose JE, Behm FM, Drgon T, et al. (2010)."Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score".Mol. Med.16(7–8): 247–53.doi:10.2119/molmed.2009.00159.PMC2896464.PMID20379614.
- Ballif BA, Villén J, Beausoleil SA, et al. (2004)."Phosphoproteomic analysis of the developing mouse brain".Mol. Cell. Proteomics.3(11): 1093–101.doi:10.1074/mcp.M400085-MCP200.PMID15345747.
- Johnson AD, Kavousi M, Smith AV, et al. (2009)."Genome-wide association meta-analysis for total serum bilirubin levels".Hum. Mol. Genet.18(14): 2700–10.doi:10.1093/hmg/ddp202.PMC2701336.PMID19414484.
- Lim J, Hao T, Shaw C, et al. (2006)."A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration".Cell.125(4): 801–14.doi:10.1016/j.cell.2006.03.032.PMID16713569.S2CID13709685.
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