KCNQgenes encode family members of the Kv7potassium channelfamily. These include Kv7.1 (KCNQ1) -KvLQT1,Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), and Kv7.5 (KCNQ5). Four of these (KCNQ2-5) are expressed in the nervous system. They constitute a group of low-threshold voltage-gated K+channels originally termed the ‘M-channel’ (seeM-current). The M-channel name comes from the classically described mechanism wherein the activation of themuscarinic acetylcholine receptordeactivated this channel.[1]
References
edit- ^Brown, David A; Passmore, Gayle M (April 2009)."Neural KCNQ (Kv7) channels".British Journal of Pharmacology.156(8): 1185–1195.doi:10.1111/j.1476-5381.2009.00111.x.ISSN0007-1188.PMC2697739.PMID19298256.
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