MAP3K11

"MLK3" redirects here. For the American activist, seeMartin Luther King III.

Mitogen-activated protein kinase kinase kinase 11is anenzymethat in humans is encoded by theMAP3K11gene.

MAP3K11
Identifiers
Aliases	MAP3K11,MEKK11, MLK-3, MLK3, PTK1, SPRK, mitogen-activated protein kinase kinase kinase 11
External IDs	OMIM:600050;MGI:1346880;HomoloGene:37618;GeneCards:MAP3K11;OMA:MAP3K11 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 65,597,756bp End 65,615,382bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 4.34 cM Start 5,738,770bp End 5,752,893bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in sural nerve granulocyte apex of heart mucosa of transverse colon right lobe of liver monocyte right lung spleen C1 segment upper lobe of left lung Top expressed in granulocyte yolk sac lip external carotid artery internal carotid artery intestinal villus right kidney thymus crypt of lieberkuhn of small intestine zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein homodimerization activity mitogen-activated protein kinase kinase kinase binding kinase activity protein binding identical protein binding mitogen-activated protein kinase kinase binding ATP binding MAP kinase kinase kinase activity protein serine/threonine kinase activity protein kinase activity JUN kinase kinase kinase activity protein tyrosine kinase activity Cellular component centrosome membrane microtubule organizing center microtubule cytoskeleton cytoplasm intracellular anatomical structure Biological process phosphorylation positive regulation of JUN kinase activity cell death positive regulation of JNK cascade positive regulation of neuron apoptotic process microtubule-based process cell population proliferation protein autophosphorylation JNK cascade protein phosphorylation positive regulation of apoptotic process MAPK cascade peptidyl-tyrosine phosphorylation Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 4296 26403 Ensembl ENSG00000173327 ENSMUSG00000004054 UniProt Q16584 Q80XI6 RefSeq (mRNA) NM_002419 NM_022012 RefSeq (protein) NP_002410 NP_002410.1 NP_071295 Location (UCSC) Chr 11: 65.6 – 65.62 Mb Chr 19: 5.74 – 5.75 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is called MLK3 and it is a member of the serine/threoninekinasefamily. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.

Interactions

MAP3K11 has been shown tointeractwith:

• AKT1,
• CDC42,
• MAPK8IP1,
• MAPK8IP2,and
• SH3RF1.

Further reading

• van de Bovenkamp M, Nottet HS, Pereira CF (2003)."Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia".Eur. J. Clin. Invest.32(8): 619–27.doi:10.1046/j.1365-2362.2002.01029.x.PMID12190962.S2CID37260932.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ (1994)."Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity".J. Biol. Chem.269(21): 15092–100.doi:10.1016/S0021-9258(17)36578-X.PMID8195146.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• Tanaka S, Hanafusa H (1998)."Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases".J. Biol. Chem.273(3): 1281–4.doi:10.1074/jbc.273.3.1281.PMID9430657.
• Leung IW, Lassam N (1999)."Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3".J. Biol. Chem.273(49): 32408–15.doi:10.1074/jbc.273.49.32408.PMID9829970.
• Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB (1999)."The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate".J. Biol. Chem.274(15): 10195–202.doi:10.1074/jbc.274.15.10195.PMID10187804.
• Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (2000)."The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins".Mol. Cell. Biol.19(10): 7245–54.doi:10.1128/mcb.19.10.7245.PMC84717.PMID10490659.
• Kelkar N, Gupta S, Dickens M, Davis RJ (2000)."Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3".Mol. Cell. Biol.20(3): 1030–43.doi:10.1128/MCB.20.3.1030-1043.2000.PMC85220.PMID10629060.
• Hehner SP, Hofmann TG, Ushmorov A, Dienz O, Wing-Lan Leung I, Lassam N, Scheidereit C, Dröge W, Schmitz ML (2000)."Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex".Mol. Cell. Biol.20(7): 2556–68.doi:10.1128/MCB.20.7.2556-2568.2000.PMC85472.PMID10713178.
• Böck BC, Vacratsis PO, Qamirani E, Gallo KA (2000)."Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation".J. Biol. Chem.275(19): 14231–41.doi:10.1074/jbc.275.19.14231.PMID10799501.
• Leung IW, Lassam N (2001)."The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation".J. Biol. Chem.276(3): 1961–7.doi:10.1074/jbc.M004092200.PMID11053428.
• Svensson AC, Raudsepp T, Larsson C, Di Cristofano A, Chowdhary B, La Mantia G, Rask L, Andersson G (2001). "Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9".Cytogenet. Cell Genet.92(1–2): 89–96.doi:10.1159/000056875.PMID11306803.S2CID19266745.
• Zhang H, Gallo KA (2002)."Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain".J. Biol. Chem.276(49): 45598–603.doi:10.1074/jbc.M107176200.PMID11590155.
• Lambert JM, Karnoub AE, Graves LM, Campbell SL, Der CJ (2002)."Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation".J. Biol. Chem.277(7): 4770–7.doi:10.1074/jbc.M109379200.PMID11713255.
• Chadee DN, Yuasa T, Kyriakis JM (2002)."Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2".Mol. Cell. Biol.22(3): 737–49.doi:10.1128/MCB.22.3.737-749.2002.PMC133545.PMID11784851.
• Vacratsis PO, Phinney BS, Gage DA, Gallo KA (2002). "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping".Biochemistry.41(17): 5613–24.CiteSeerX10.1.1.381.6228.doi:10.1021/bi016075c.PMID11969422.