Obsessive–compulsive disorder

"OCD" redirects here. Not to be confused withObsessive–compulsive personality disorder.For other uses, seeOCD (disambiguation).

Obsessive–compulsive disorder(OCD) is amentalandbehavioraldisorderin which an individual hasintrusive thoughts(anobsession) and feels the need to perform certain routines (compulsions) repeatedly to relieve the distress caused by the obsession, to the extent where it impairs general function.

Obsessive–compulsive disorder
Frequent and excessive hand washing occurs in some people with OCD.
Specialty	Psychiatry
Symptoms	Feel the need to check things repeatedly, performcertain routines repeatedly,havecertain thoughts repeatedly
Complications	Tics,anxiety disorder,suicide
Usual onset	Before 35 years
Risk factors	Genetics,biology,temperament,childhood trauma
Diagnostic method	Clinically based on symptoms; Y-BOCS is the gold standard tool to assess severity
Differential diagnosis	Anxiety disorder,major depressive disorder,eating disorders,tic disorders,obsessive–compulsive personality disorder
Treatment	Counseling,selective serotonin reuptake inhibitors,clomipramine
Frequency	2.3%

Obsessions are persistent unwanted thoughts, mental images, or urges that generate feelings ofanxiety,disgust,or discomfort.Some common obsessions include fear ofcontamination,obsession withsymmetry,the fear of actingblasphemously,the sufferer'ssexual orientation,and the fear of possibly harming others or themselves.Compulsions are repeated actions or routines that occur in response to obsessions to achieve a relief from anxiety. Common compulsions include excessivehand washing,cleaning,counting,ordering, repeating, avoiding triggers,hoarding,neutralizing, seeking assurance, praying, and checking things.People with OCD may only perform mental compulsions such as needing to know or remember things. While this is sometimes referred to asprimarily obsessional obsessive–compulsive disorder(Pure O), it is also considered a misnomer due to associated mental compulsions and reassurance seeking behaviors that are consistent with OCD.

Compulsions occur often and typically take up at least one hour per day, impairing one's quality of life.Compulsions cause relief in the moment, but cause obsessions to grow over time due to the repeated reward-seeking behavior of completing the ritual for relief. Many adults with OCD are aware that their compulsions do not make sense, but they still perform them to relieve the distress caused by obsessions.For this reason, thoughts and behaviors in OCD are usually consideredegodystonic.In contrast, thoughts and behaviors inobsessive–compulsive personality disorder(OCPD) are usually consideredegosyntonic,helping differentiate between the two.

Although the exact cause of OCD is unknown, several regions of the brain have been implicated in its neuroanatomical model including theanterior cingulate cortex,orbitofrontal cortex,amygdala,andBNST.The presence of ageneticcomponent is evidenced by the increased likelihood for bothidentical twinsto be affected than bothfraternal twins.Risk factors include a history ofchild abuseor otherstress-inducing events such as during the postpartum period or afterstreptococcal infections.Diagnosis is based on clinical presentation and requires ruling out other drug-related or medical causes; rating scales such as theYale–Brown Obsessive–Compulsive Scale(Y-BOCS) assess severity.Other disorders with similar symptoms includegeneralized anxiety disorder,major depressive disorder,eating disorders,tic disorders,body-focused repetitive behavior,andobsessive–compulsive personality disorder.Personality disorders are a common comorbidity, with schizotypal and OCPD having poor treatment response.The condition is also associated with a general increase insuicidality.The phraseobsessive–compulsiveis sometimes used in an informal manner unrelated to OCD to describe someone as excessively meticulous,perfectionistic,absorbed, or otherwise fixated.However, the actual disorder can vary in presentation, and individuals with OCD may not be concerned with cleanliness or symmetry.

OCD is chronic and long-lasting with periods of severe symptoms followed by periods of improvement.Treatment can improve ability to function and quality of life, and is usually reflected by improvedY-BOCSscores.Treatment for OCD may involvepsychotherapy,pharmacotherapysuch asantidepressants,orsurgicalprocedures such asdeep brain stimulationor, in extreme cases,psychosurgery.Psychotherapies derived fromcognitive behavioral therapy(CBT) models, such asexposure and response prevention,acceptance and commitment therapy,andinference based-therapy,are more effective than non-CBT interventions.Selective serotonin reuptake inhibitors(SSRIs) are more effective when used in excess of the recommended depression dosage; however, higher doses can increase side effect intensity.Commonly used SSRIs includesertraline,fluoxetine,fluvoxamine,paroxetine,citalopram,andescitalopram.Some patients fail to improve after taking the maximum tolerated dose of multiple SSRIs for at least two months; these cases qualify as treatment-resistant and can require second-line treatment such asclomipramineoratypical antipsychoticaugmentation.While SSRIs continue to be first-line, recent data for treatment-resistant OCD supports adjunctive use of neuroleptic medications, deep brain stimulation, and neurosurgical ablation.There is growing evidence to support the use ofdeep brain stimulationand repetitivetranscranial magnetic stimulationfor treatment-resistant OCD.

Obsessive–compulsive disorder affects about 2.3% of people at some point in their lives, while rates during any given year are about 1.2%.More than three million Americans suffer from OCD.According toMercy,approximately 1 in 40 U.S. adults and 1 in 100 U.S. children have OCD.Although possible at times with triggers such aspregnancy,onset rarely occurs after age 35, and about 50% of patients experience detrimental effects to daily life before age 20.While OCD occurs worldwide,a recent meta-analysis showed that women are 1.6 times more likely to experience OCD.Based on data from 34 studies, the worldwide prevalence rate is 1.5% in women and 1% in men.

Signs and symptoms

OCD can present with a wide variety of symptoms. Certain groups of symptoms usually occur together as dimensions or clusters, which may reflect an underlying process. The standard assessment tool for OCD, theYale–Brown Obsessive Compulsive Scale(Y-BOCS), has 13 predefined categories of symptoms. These symptoms fit into three to five groupings.Ameta-analyticreview of symptom structures found a four-factor grouping structure to be most reliable: symmetry factor, forbidden thoughts factor, cleaning factor, and hoarding factor. The symmetry factor correlates highly with obsessions related to ordering, counting, and symmetry, as well as repeating compulsions. The forbidden thoughts factor correlates highly with intrusive thoughts of a violent, religious, or sexual nature. The cleaning factor correlates highly with obsessions about contamination and compulsions related to cleaning. The hoarding factor only involves hoarding-related obsessions and compulsions, and was identified as being distinct from other symptom groupings.

When looking into the onset of OCD, one study suggests that there are differences in the age of onset between males and females, with the average age of onset of OCD being 9.6 for male children and 11.0 for female children.Children with OCD often have other mental disorders, such as ADHD, depression, anxiety, and disruptive behavior disorder. Continually, children are more likely to struggle in school and experience difficulties in social situations (Lack 2012). When looking at both adults and children a study found the average ages of onset to be 21 and 24 for males and females respectively.While some studies have shown that OCD with earlier onset is associated with greater severity, other studies have not been able to validate this finding.Looking at women specifically, a different study suggested that 62% of participants found that their symptoms worsened at a premenstrual age. Across the board, all demographics and studies showed a mean age of onset of less than 25.

Some OCD subtypes have been associated with improvement in performance on certain tasks, such aspattern recognition(washing subtype) andspatial working memory(obsessive thought subtype). Subgroups have also been distinguished byneuroimagingfindings and treatment response, though neuroimaging studies have not been comprehensive enough to draw conclusions. Subtype-dependent treatment response has been studied, and the hoarding subtype has consistently been least responsive to treatment.

While OCD is considered ahomogeneousdisorder from aneuropsychologicalperspective, many of the symptoms may be the result ofcomorbiddisorders. For example, adults with OCD have exhibited more symptoms ofattention deficit hyperactivity disorder(ADHD) andautism spectrum disorder(ASD) than adults without OCD.

In regards to the cause of onset, researchers asked participants in one studywhat they felt was responsible for triggering the initial onset of their illness. 29% of patients answered that there was an environmental factor in their life that did so. Specifically, the majority of participants who answered with that noted their environmental factor to be related to an increased responsibility.

Obsessions

Main article:Intrusive thought

See also:Primarily obsessional obsessive–compulsive disorder

People with OCD may face intrusive thoughts, such as thoughts about thedevil(shown is a painted interpretation ofHell).

Obsessions are stress-inducing thoughts that recur and persist, despite efforts to ignore or confront them.People with OCD frequently perform tasks, orcompulsions,to seek relief from obsession-related anxiety. Within and among individuals, initial obsessions vary in clarity and vividness. A relatively vague obsession could involve a general sense of disarray or tension, accompanied by a belief that life cannot proceed as normal while the imbalance remains. A more intense obsession could be a preoccupation with the thought or image of a close family member or friend dying, or intrusive thoughts related torelationship rightness.Other obsessions concern the possibility that someone or something other than oneself—such asGod,thedevil,ordisease—will harm either the patient or the people or things the patient cares about. Others with OCD may experience the sensation of invisible protrusions emanating from their bodies, or feel thatinanimate objects are ensouled.Another common obsession isscrupulosity,the pathological guilt/anxiety about moral or religious issues. In scrupulosity, a person's obsessions focus on moral or religious fears, such as the fear of being an evil person or the fear of divine retribution for sin.Mysophobia,apathological fearof contamination andgerms,is another common obsession theme.

Some people with OCD experiencesexual obsessionsthat may involve intrusive thoughts or images of "kissing, touching, fondling,oral sex,anal sex,intercourse,incest,andrape"with" strangers, acquaintances, parents, children, family members, friends, coworkers, animals, and religious figures ", and can includeheterosexualorhomosexualcontact with people of any age.Similar to other intrusive thoughts or images, some disquieting sexual thoughts are normal at times, but people with OCD may attach extraordinary significance to such thoughts. For example, obsessive fears aboutsexual orientationcan appear to the affected individual, and even to those around them, as a crisis ofsexual identity.Furthermore, the doubt that accompanies OCD leads to uncertainty regarding whether one might act on the troubling thoughts, resulting in self-criticism or self-loathing.

Most people with OCD understand that their thoughts do not correspond with reality; however, they feel that they must act as though these ideas are correct or realistic. For example, someone who engages incompulsive hoardingmight be inclined to treat inorganic matter as if it had the sentience or rights of living organisms, despite accepting that such behavior is irrational on an intellectual level. There is debate as to whether hoarding should be considered an independent syndrome from OCD.

Compulsions

Main article:Compulsive behavior

A person exhibitingskin-picking disorder

Some people with OCD perform compulsive rituals because they inexplicably feel that they must do so, while others act compulsively to mitigate the anxiety that stems from obsessive thoughts. The affected individual might feel that these actions will either prevent a dreaded event from occurring, or push the event from their thoughts. In any case, their reasoning is soidiosyncraticor distorted that it results in significant distress, either personally, or for those around the affected individual. Excessiveskin picking,hair pulling,nail biting,and other body-focused repetitive behavior disorders are all on theobsessive–compulsive spectrum.Some individuals with OCD are aware that their behaviors are not rational, but they feel compelled to follow through with them to fend off feelings of panic or dread.Furthermore, compulsions often stem frommemory distrust,a symptom of OCD characterized by insecurity in one's skills inperception,attention,andmemory,even in cases where there is no clear evidence of a deficit.

Common compulsions may include hand washing, cleaning, checking things (such as locks on doors), repeating actions (such as repeatedly turning on and off switches), ordering items in a certain way, and requesting reassurance.Although some individuals perform actions repeatedly, they do not necessarily perform these actions compulsively; for example, morning or nighttime routines and religious practices are not usually compulsions. Whether behaviors qualify as compulsions or mere habit depends on the context in which they are performed. For instance, arranging and ordering books for eight hours a day would be expected of someone who works in a library, but this routine would seem abnormal in other situations. In other words, habits tend to bring efficiency to one's life, while compulsions tend to disrupt it.Furthermore, compulsions are different fromtics(such as touching, tapping, rubbing, or blinking) andstereotyped movements(such as head banging, body rocking, or self-biting), which are usually not as complex and not precipitated by obsessions.It can sometimes be difficult to tell the difference between compulsions and complex tics, and about 10–40% of people with OCD also have a lifetime tic disorder.

People with OCD rely on compulsions as an escape from their obsessive thoughts; however, they are aware that relief is only temporary, and that intrusive thoughts will return. Some affected individuals use compulsions to avoid situations that may trigger obsessions. Compulsions may be actions directly related to the obsession, such as someone obsessed with contamination compulsively washing their hands, but they can be unrelated as well.In addition to experiencing the anxiety and fear that typically accompanies OCD, affected individuals may spend hours performing compulsions every day. In such situations, it can become difficult for the person to fulfill their work, familial, or social roles. These behaviors can also cause adverse physical symptoms; for example, people who obsessively wash their hands withantibacterial soapand hot water can make their skin red and raw withdermatitis.

Individuals with OCD often userationalizationsto explain their behavior; however, these rationalizations do not apply to the behavioral pattern, but to each individual occurrence. For example, someone compulsively checking the front door may argue that the time and stress associated with one check is less than the time and stress associated with being robbed, and checking is consequently the better option. This reasoning often occurs in a cyclical manner, and can continue for as long as the affected person needs it to in order to feel safe.

Incognitive behavioral therapy(CBT), OCD patients are asked to overcome intrusive thoughts by not indulging in any compulsions. They are taught that rituals keep OCD strong, while not performing them causes OCD to become weaker.This position is supported by the pattern of memory distrust; the more often compulsions are repeated, the more weakened memory trust becomes, and this cycle continues as memory distrust increases compulsion frequency.Forbody-focused repetitive behaviors(BFRB) such astrichotillomania(hair pulling),skin picking,andonychophagia(nail biting), behavioral interventions such ashabit reversal traininganddecouplingare recommended for the treatment of compulsive behaviors.

OCD sometimes manifests without overt compulsions, which may be termed "primarily obsessional OCD." OCD without overt compulsions could, by one estimate, characterize as many as 50–60% of OCD cases.

Insight and overvalued ideation

TheDiagnostic and Statistical Manual of Mental Disorders(DSM-5), identifies a continuum for the level of insight in OCD, ranging from good insight (the least severe) to no insight (the most severe). Good or fair insight is characterized by the acknowledgment that obsessive–compulsive beliefs are not or may not be true, while poor insight, in the middle of the continuum, is characterized by the belief that obsessive–compulsive beliefs are probably true. The absence of insight altogether, in which the individual is completely convinced that their beliefs are true, is also identified as adelusionalthought pattern, and occurs in about 4% of people with OCD.When cases of OCD with no insight become severe, affected individuals have an unshakable belief in the reality of their delusions, which can make their cases difficult to differentiate frompsychotic disorders.

Some people with OCD exhibit what is known asovervalued ideas,ideas that are abnormal compared to affected individuals' respective cultures, and more treatment-resistant than most negative thoughts and obsessions.After some discussion, it is possible to convince the individual that their fears are unfounded. It may be more difficult to practiceexposure and response prevention therapy(ERP) on such people, as they may be unwilling to cooperate, at least initially.Similar to how insight is identified on a continuum, obsessive-compulsive beliefs are characterized on a spectrum, ranging from obsessive doubt to delusional conviction. In theUnited States,overvalued ideation (OVI) is considered most akin to poor insight—especially when considering belief strength as one of an idea's key identifiers.Furthermore, severe and frequent overvalued ideas are considered similar toidealized values,which are so rigidly held by, and so important to affected individuals, that they end up becoming a defining identity.In adolescent OCD patients, OVI is considered a severe symptom.

Historically, OVI has been thought to be linked to poorer treatment outcome in patients with OCD, but it is currently considered a poor indicator of prognosis.The Overvalued Ideas Scale (OVIS) has been developed as a reliable quantitative method of measuring levels of OVI in patients with OCD, and research has suggested that overvalued ideas are more stable for those with more extreme OVIS scores.

Cognitive performance

Though OCD was once believed to be associated with above-average intelligence, this does not appear to necessarily be the case.A 2013 review reported that people with OCD may sometimes have mild but wide-rangingcognitive deficits,most significantly those affectingspatial memoryand to a lesser extent withverbal memory,fluency,executive function,andprocessing speed,while auditory attention was not significantly affected.People with OCD show impairment in formulating an organizational strategy for coding information,set-shifting,and motor andcognitive inhibition.

Specific subtypes of symptom dimensions in OCD have been associated with specific cognitive deficits.For example, the results of onemeta-analysiscomparing washing and checking symptoms reported that washers outperformed checkers on eight out of ten cognitive tests.The symptom dimension of contamination and cleaning may be associated with higher scores on tests of inhibition and verbal memory.

Video game addiction

See also:Video game addiction

This section is an excerpt fromDigital media use and mental health § OCD.[edit]

In April 2018, theInternational Journal of Environmental Research and Public Healthpublished a systematic review of 24 studies researching associations between internet gaming disorder (IGD) and various psychopathologies that found a significant correlation between IGD and obsessive–compulsive disorder symptoms in 3 of 4 studies.

Pediatric OCD

Approximately 1–2% of children are affected by OCD.There is a lot of similarity between the clinical presentation of OCD in children and adults, and it is considered a highly familial disorder, with a phenotypic heritability of around 50%.Obsessive–compulsive disorder symptoms tend to develop more frequently in children 10–14 years of age, with males displaying symptoms at an earlier age, and at a more severe level than females.In children, symptoms can be grouped into at least four types, including sporadic and tic-related OCD.

The Children's Yale–Brown Obsessive–Compulsive Scale (CY-BOCS) is the gold standard measure for assessment of pediatric OCD.It follows the Y-BOCS format, but with a Symptom Checklist that is adapted for developmental appropriateness. Insight, avoidance, indecisiveness, responsibility, pervasive slowness, and doubting, are not included in a rating of overall severity. The CY-BOCS has demonstrated good convergent validity with clinician-rated OCD severity, and good to fair discriminant validity from measures of closely related anxiety, depression, and tic severity.The CY-BOCS Total Severity score is an important monitoring tool as it is responsive to pharmacotherapy and psychotherapy.Positive treatment response is characterized by 25% reduction in CY-BOCS total score, and diagnostic remission is associated with a 45%-50% reduction in Total Severity score (or a score <15).

CBT is the first line treatment for mild to moderate cases of OCD in children, while medication plus CBT is recommended for moderate to severe cases.Serotonin reuptake inhibitors (SRIs) are first-line medications for OCD in children with established AACAP guidelines for dosing.

Associated conditions

People with OCD may be diagnosed with other conditions as well, such as obsessive–compulsive personality disorder,major depressive disorder,bipolar disorder,generalized anxiety disorder,anorexia nervosa,social anxiety disorder,bulimia nervosa,Tourette syndrome,transformation obsession,ASD, ADHD,dermatillomania,body dysmorphic disorder,andtrichotillomania.More than 50% of people with OCD experience suicidal tendencies, and 15% have attemptedsuicide.Depression, anxiety, and prior suicide attempts increase the risk of future suicide attempts.

It has been found that between 18 and 34% of females currently experiencing OCD scored positively on an inventory measuring disordered eating.Another study found that 7% are likely to have an eating disorder,while another found that fewer than 5% of males have OCD and an eating disorder.

Individuals with OCD have also been found to be affected bydelayed sleep phase disorderat a substantially higher rate than the general public.Moreover, severe OCD symptoms are consistently associated with greatersleep disturbance.Reduced total sleep time and sleep efficiency have been observed in people with OCD, with delayed sleep onset and offset.

Some research has demonstrated a link betweendrug addictionand OCD. For example, there is a higher risk of drug addiction among those with any anxiety disorder, likely as a way ofcopingwith the heightened levels of anxiety. However, drug addiction among people with OCD may be a compulsive behavior. Depression is also extremely prevalent among people with OCD. One explanation for the high depression rate among OCD populations was posited by Mineka, Watson, and Clark (1998), who explained that people with OCD, or any other anxiety disorder, may feel "out of control".

Someone exhibiting OCD signs does not necessarily have OCD. Behaviors that present as obsessive–compulsive can also be found in a number of other conditions, includingobsessive–compulsive personality disorder(OCPD), autism spectrum disorder (ASD), or disorders in whichperseverationis a possible feature (ADHD,PTSD,bodily disorders, orstereotyped behaviors).Some cases of OCD present symptoms typically associated with Tourette syndrome, such as compulsions that may appear to resemblemotor tics;this has been termedtic-related OCDorTourettic OCD.

OCD frequently occurscomorbidlywith bothbipolar disorderandmajor depressive disorder.Between 60 and 80% of those with OCD experience a major depressive episode in their lifetime. Comorbidity rates have been reported at between 19 and 90%, as a result of methodological differences. Between 9–35% of those with bipolar disorder also have OCD, compared to 1–2% in the general population. About 50% of those with OCD experiencecyclothymictraits orhypomanicepisodes. OCD is also associated with anxiety disorders. Lifetime comorbidity for OCD has been reported at 22% forspecific phobia,18% forsocial anxiety disorder,12% forpanic disorder,and 30% forgeneralized anxiety disorder.The comorbidity rate for OCD and ADHD has been reported to be as high as 51%.

Causes

Main article:Cause of obsessive-compulsive disorder

The cause of OCD is unknown.Both environmental and genetic factors are believed to play a role. Risk factors include a history ofadverse childhood experiencesor otherstress-inducing events.

Drug-induced OCD

Some medications, toxin exposures, and drugs, such asmethamphetamineorcocaine,can induce obsessive–compulsive symptoms in people without a history of OCD.Atypical antipsychoticssuch asolanzapineandclozapinecan induce OCD in some people, particularly individuals withschizophrenia.

The diagnostic criteria include:

1) General OCD symptoms (obsessions, compulsions, skin picking, hair pulling, etc.) that developed soon after exposure to the substance or medication which can produce such symptoms.

2) The onset of symptoms cannot be explained by an obsessive–compulsive and related disorder that is not substance/medication-induced and should last for a substantial period of time (about 1 month)

3) This disturbance does not only occur duringdelirium.

4) Clinically induces distress or impairment in social, occupational, or other important areas of functioning.

Genetics

There appear to be somegeneticcomponents of OCD causation, withidentical twinsmore often affected than fraternal twins.Furthermore, individuals with OCD are more likely to have first-degree family members exhibiting the same disorders thanmatched controls.In cases in which OCD develops during childhood, there is a much stronger familial link in the disorder than with cases in which OCD develops later in adulthood. In general, genetic factors account for 45–65% of the variability in OCD symptoms in children diagnosed with the disorder.A 2007 study found evidence supporting the possibility of a heritable risk for OCD.

Research has found there to be a genetic correlation between anorexia nervosa and OCD, suggesting a strong etiology.First and second hand relatives of probands with OCD have a greater risk of developing anorexia nervosa as genetic relatedness increases.

Amutationhas been found in the humanserotonintransporter genehSERTin unrelated families with OCD.

Asystematic reviewfound that while neitherallelewas associated with OCD overall, inCaucasians,the L allele was associated with OCD.Another meta-analysis observed an increased risk in those with thehomozygousS allele, but found the LSgenotypeto be inversely associated with OCD.

Agenome-wide association study found OCD to be linked withsingle-nucleotide polymorphisms(SNPs) nearBTBD3,and two SNPs inDLGAP1in a trio-based analysis, but no SNP reached significance when analyzed withcase-controldata.

One meta-analysis found a small but significant association between a polymorphism inSLC1A1and OCD.

The relationship between OCD andCatechol-O-methyltransferase(COMT) has been inconsistent, with one meta-analysis reporting a significant association, albeit only in men, and another meta analysis reporting no association.

It has been postulated byevolutionary psychologiststhat moderate versions of compulsive behavior may have had evolutionary advantages. Examples would be moderate constant checking of hygiene, thehearth,or the environment for enemies. Similarly,hoardingmay have had evolutionary advantages. In this view, OCD may be the extreme statistical tail of such behaviors, possibly the result of a high number of predisposing genes.

Brain structure and functioning

Imagingstudies have shown differences in thefrontal cortexandsubcorticalstructures of the brain in patients with OCD. There appears to be a connection between the OCD symptoms and abnormalities in certain areas of the brain, but such a connection is not clear.Some people with OCD have areas of unusually high activity in their brain, or low levels of the chemicalserotonin,which is aneurotransmitterthat somenerve cellsuse to communicate with each other,and is thought to be involved in regulating many functions, influencing emotions, mood, memory, and sleep.

Autoimmune

A controversial hypothesis is that some cases of rapid onset of OCD in children and adolescents may be caused by a syndrome connected toGroup A streptococcal infections(GABHS), known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).OCD and tic disorders are hypothesized to arise in a subset of children as a result of a post-streptococcalautoimmune process.The PANDAS hypothesis is unconfirmed and unsupported by data, and two new categories have been proposed:PANS(pediatric acute-onset neuropsychiatric syndrome) and CANS (childhood acute neuropsychiatric syndrome).The CANS and PANS hypotheses include different possible mechanisms underlying acute-onset neuropsychiatric conditions, but do not exclude GABHS infections as a cause in a subset of individuals.PANDAS, PANS, and CANS are the focus of clinical and laboratory research, but remain unproven.Whether PANDAS is a distinct entity differing from other cases of tic disorders or OCD is debated.

A review of studies examining anti-basal gangliaantibodiesin OCD found an increased risk of having anti-basal ganglia antibodies in those with OCD versus the general population.

Environment

OCD may be more common in people who have been bullied, abused, or neglected, and it sometimes starts after a significant life event, such as childbirth orbereavement.It has been reported in some studies that there is a connection betweenchildhood traumaand obsessive-compulsive symptoms. More research is needed to understand this relationship better.

Mechanisms

Main article:Biology of obsessive–compulsive disorder

Neuroimaging

Some parts of the brain showing abnormal activity in OCD: Orbitofrontal cortex integrates rewards, emotions, and behaviors; anterior cingulate cortex is involved in error detection; amygdala is involved in emotional interpretation of reward

Functional neuroimaging during symptom provocation has observed abnormal activity in theorbitofrontal cortex(OFC), leftdorsolateral prefrontal cortex(dlPFC), rightpremotor cortex,left superiortemporal gyrus,globus pallidus externus,hippocampus,and rightuncus.Weaker foci of abnormal activity were found in the leftcaudate,posterior cingulate cortex,andsuperior parietal lobule.However, an older meta-analysis of functional neuroimaging in OCD reported that the only consistent functional neuroimaging finding was increased activity in theorbital gyrusand head of thecaudate nucleus,whileanterior cingulate cortex(ACC) activation abnormalities were too inconsistent.

A meta-analysis comparing affective and nonaffective tasks observed differences with controls in regions implicated insalience,habit, goal-directed behavior, self-referential thinking, and cognitive control. For nonaffective tasks, hyperactivity was observed in theinsula,ACC, and head of thecaudate/putamen,while hypoactivity was observed in themedial prefrontal cortex(mPFC) and posterior caudate. Affective tasks were observed to relate to increased activation in theprecuneusandposterior cingulate cortex,while decreased activation was found in thepallidum,ventral anterior thalamus, and posterior caudate.The involvement of thecortico-striato-thalamo-corticalloop in OCD, as well as the high rates of comorbidity between OCD and ADHD, have led some to draw a link in their mechanism. Observed similarities include dysfunction of theanterior cingulate cortexandprefrontal cortex,as well as shared deficits in executive functions.The involvement of the orbitofrontal cortex and dorsolateral prefrontal cortex in OCD is shared withbipolar disorder,and may explain the high degree of comorbidity.Decreased volumes of the dorsolateral prefrontal cortex related to executive function has also been observed in OCD.

People with OCD evince increasedgrey mattervolumes in bilaterallenticular nuclei,extending to the caudate nuclei, with decreased grey matter volumes in bilateral dorsalmedial frontal/anterior cingulategyri.These findings contrast with those in people with other anxiety disorders, who evince decreased (rather than increased) grey matter volumes in bilateral lenticular/caudate nuclei, as well as decreased grey matter volumes in bilateral dorsalmedial frontal/anterior cingulategyri.Increasedwhite mattervolume and decreasedfractional anisotropyin anterior midline tracts has been observed in OCD, possibly indicating increased fiber crossings.

Cognitive models

Generally, two categories of models for OCD have been postulated. The first category involves deficits in executive dysfunction and is based on the observed structural and functional abnormalities in the dlPFC,striatumand thalamus. The second category involves dysfunctional modulatory control and primarily relies on observed functional and structural differences in the ACC, mPFC, and OFC.

One proposed model suggests that dysfunction in theorbitalfrontal cortex(OFC) leads to improper valuation of behaviors and decreased behavioral control, while the observed alterations inamygdalaactivations leads to exaggerated fears and representations of negative stimuli.

Due to theheterogeneityof OCD symptoms, studies differentiating various symptoms have been performed. Symptom-specific neuroimaging abnormalities include the hyperactivity of caudate and ACC in checking rituals, while finding increased activity of cortical andcerebellarregions in contamination-related symptoms. Neuroimaging differentiating content of intrusive thoughts has found differences between aggressive as opposed totaboothoughts, finding increased connectivity of theamygdala,ventral striatum,andventromedial prefrontal cortexin aggressive symptoms, while observing increased connectivity between the ventral striatum and insula in sexual or religious intrusive thoughts.

Another model proposes that affective dysregulation links excessive reliance on habit-based action selectionwith compulsions. This is supported by the observation that those with OCD demonstrate decreased activation of the ventral striatum when anticipating monetary reward, as well as increased functional connectivity between the VS and the OFC. Furthermore, those with OCD demonstrate reduced performance inPavlovianfear-extinction tasks, hyperresponsiveness in the amygdala to fearful stimuli, and hyporesponsiveness in the amygdala when exposed to positively valanced stimuli. Stimulation of thenucleus accumbenshas also been observed to effectively alleviate both obsessions and compulsions, supporting the role of affective dysregulation in generating both.

Neurobiological

From the observation of the efficacy of antidepressants in OCD, a serotonin hypothesis of OCD has been formulated. Studies of peripheral markers of serotonin, as well as challenges with proserotonergic compounds have yielded inconsistent results, including evidence pointing towards basal hyperactivity ofserotonergicsystems.Serotonin receptorand transporter binding studies have yielded conflicting results, including higher and lower serotonin receptor5-HT_2Aandserotonin transporterbinding potentials that were normalized by treatment with SSRIs. Despite inconsistencies in the types of abnormalities found, evidence points towards dysfunction of serotonergic systems in OCD.Orbitofrontal cortex overactivity is attenuated in people who have successfully responded to SSRI medication, a result believed to be caused by increased stimulation of serotonin receptors5-HT_2Aand5-HT_2C.

A complex relationship betweendopamineand OCD has been observed. Althoughantipsychotics,which act byantagonizing dopamine receptors,may improve some cases of OCD, they frequently exacerbate others. Antipsychotics, in the low doses used to treat OCD, may actually increase the release of dopamine in theprefrontal cortex,through inhibitingautoreceptors.Further complicating things is the efficacy ofamphetamines,decreaseddopamine transporteractivity observed in OCD,and low levels ofD₂binding in thestriatum.Furthermore, increased dopamine release in thenucleus accumbensafter deep brain stimulation correlates with improvement in symptoms, pointing to reduced dopamine release in the striatum playing a role in generating symptoms.

Abnormalities inglutamatergicneurotransmissionhave been implicated in OCD. Findings such as increasedcerebrospinalglutamate,less consistent abnormalities observed in neuroimaging studies, and the efficacy of some glutamatergic drugs (such as the glutamate-inhibitingriluzole) have implicated glutamate in OCD.OCD has been associated with reducedN-Acetylaspartic acidin the mPFC, which is thought to reflect neuron density or functionality, although the exact interpretation has not been established.

Diagnosis

Formal diagnosis may be performed by apsychologist,psychiatrist,clinicalsocial worker,or other licensed mental health professional. OCD, like other mental and behavioral health disorders, cannot be diagnosed by a medical exam,nor are there any medical exams that can predict if one will fall victim to such illnesses. To be diagnosed with OCD, a person must have obsessions, compulsions, or both, according to theDiagnostic and Statistical Manual of Mental Disorders(DSM). The DSM notes that there are multiple characteristics that can turn obsessions and compulsions from normalized behavior to "clinically significant." There has to be recurring and strong thoughts or impulsive that intrude on the day-to-day lives of the patients and cause noticeable levels of anxiousness.

These thoughts, impulses, or images are of a degree or type that lies outside thenormalrange of worries about conventional problems.A person may attempt to ignore orsuppresssuch obsessions, neutralize them with another thought or action, or try to rationalize their anxiety away. People with OCD tend to recognize their obsessions as irrational.

Compulsions become clinically significant when a person feels driven to perform them in response to an obsession, or according to rules that must be applied rigidly, and when the person consequently feels or causes significant distress. Therefore, while many people who do not have OCD may perform actions often associated with OCD (such as ordering items in a pantry by height), the distinction with clinically significant OCD lies in the fact that the person with OCD must perform these actions to avoid significant psychological distress. These behaviors or mental acts are aimed at preventing or reducing distress or preventing some dreaded event or situation; however, these activities are not logically or practically connected to the issue, or, they are excessive.

Moreover, the obsessions or compulsions must be time-consuming, often taking up more than one hour per day, or cause impairment in social, occupational, or scholastic functioning.It is helpful to quantify the severity of symptoms and impairment before and during treatment for OCD. In addition to the person's estimate of the time spent each day harboring obsessive-compulsive thoughts or behaviors, concrete tools can be used to gauge the person's condition. This may be done with rating scales, such as theYale–Brown Obsessive Compulsive Scale(Y-BOCS; expert rating)or the obsessive–compulsive inventory (OCI-R; self-rating).With measurements such as these, psychiatric consultation can be more appropriately determined, as it has been standardized.

In regards to diagnosing, the health professional also looks to make sure that the signs of obsessions and compulsions are not the results of any drugs, prescription or recreational, that the patient may be taking.

There are several types of obsessive thoughts that are found commonly in those with OCD. Some of these include fear of germs, hurting loved ones, embarrassment, neatness, societally unacceptable sexual thoughts etc.Within OCD, these specific categories are often diagnosed into their own type of OCD.

OCD is sometimes placed in a group of disorders called theobsessive–compulsive spectrum.

Another criterion in the DSM is that a person's mental illness does not fit one of the other categories of a mental disorder better. That is to say, if the obsessions and compulsions of a patient could be better described bytrichotillomania,it would not be diagnosed as OCD.That being said, OCD does often go hand in hand with other mental disorders. For this reason, one may be diagnosed with multiple mental disorders at once.

A different aspect of the diagnoses is the degree of insight had by the individual in regards to the truth of the obsessions. There are three levels, good/fair, poor and absent/delusional. Good/fair indicated that the patient is aware that the obsessions they have are not true or probably not true.Poor indicates that the patient believes their obsessional beliefs are probably true.Absent/delusional indicates that they fully believe their obsessional thoughts to be true.Approximately 4% or fewer individuals with OCD will be diagnosed as absent/delusional.Additionally, as many as 30% of those with OCD also have a lifetime tic disorder, meaning they have been diagnosed with a tic disorder at some point in their life.

There are several different types of tics that have been observed in individuals with OCD. These include but are not limited to, "grunting", "jerking" or "shrugging" body parts, sniffling, and excessive blinking.

There has been a significant amount of progress over the last few decades, and as of 2022 there is statically significant improvement in the diagnostic process for individuals with OCD. One study found that of two groups of individuals, one with participants under the age of 27.25 and one with participants over that age, those in the younger group experienced a significantly faster time between the onset of OCD tendencies and their formal diagnoses.

Differential diagnosis

OCD is often confused with the separate conditionobsessive–compulsive personality disorder(OCPD). OCD isegodystonic,meaning that the disorder is incompatible with the individual'sself-concept.As egodystonic disorders go against a person's self-concept, they tend to cause much distress. OCPD, on the other hand, isegosyntonic,marked by the person's acceptance that the characteristics and behaviors displayed as a result are compatible with theirself-image,or are otherwise appropriate, correct, or reasonable.

As a result, people with OCD are often aware that their behavior is not rational, and are unhappy about their obsessions, but nevertheless feel compelled by them.By contrast, people with OCPD are not aware of anything abnormal; they will readily explain why their actions are rational. It is usually impossible to convince them otherwise, and they tend to derive pleasure from their obsessions or compulsions.

Management

Cognitive behavioral therapy(CBT) andpsychotropic medicationsare the first-line treatments for OCD.

Therapy

One exposure and ritual prevention activity would be to check the lock only once and then leave.

One specific CBT technique used is calledexposure and response prevention(ERP), which involves teaching the person to deliberately come into contact with situations that trigger obsessive thoughts and fears (exposure), without carrying out the usual compulsive acts associated with the obsession (response prevention). This technique causes patients to gradually learn to tolerate the discomfort and anxiety associated with not performing their compulsions. For many patients, ERP is the add-on treatment of choice whenselective serotonin reuptake inhibitors(SSRIs) orserotonin–norepinephrine reuptake inhibitors(SNRIs) medication does not effectively treat OCD symptoms, or vice versa, for individuals who begin treatment with psychotherapy.This technique is considered superior to others due to the lack of medication used. However, up to 25% of patients will discontinue treatment due to the severity of their tics. CBT normally lasts anywhere from 12-16 sessions, withhomeworkassigned to the patient in between meetings with a therapist. (Lack 2012). Modalities differ in ERP treatment but both virtual reality based as well as unguided computer assisted treatment programs have shown effective results in treatment programs.

For example, a patient might be asked to touch something very mildly contaminated (exposure), and wash their hands only once afterward (response prevention). Another example might entail asking the patient to leave the house and check the lock only once (exposure), without going back to check again (response prevention). After succeeding at one stage of treatment, the patient's level of discomfort in the exposure phase can be increased. When this therapy is successful, the patient will quicklyhabituateto an anxiety-producing situation, discovering a considerable drop in anxiety level.

ERP has a strong evidence base, and is considered the most effective treatment for OCD.However, this claim was doubted by some researchers in 2000, who criticized the quality of many studies.While ERP can lead a majority of clients to improvements, many do not reach remission or become asymptomatic;some therapists are also hesitant to use this approach.

The recent development of remotely technology-delivered CBT is increasing access to therapy options for those living with OCD and remote versions appear to equally as effective as in-person therapy options. The development of smartphone interventions for OCD that utilize CBT techniques are another alternative that is expanding access to therapy while allowing therapies to be personalized for each patient.

Acceptance and commitment therapy(ACT), a newer therapy also used to treat anxiety and depression, has also been found to be effective in treatment of OCD.ACT usesacceptanceandmindfulnessstrategies to teach patients not to overreact to or avoid unpleasant thoughts and feelings but rather "move toward valued behavior."

Inference-based therapy(IBT) is a form ofcognitive therapyspecifically developed for treating OCD.The therapy posits that individuals with OCD put a greater emphasis on an imagined possibility than on what can be perceived with thesenses,and confuse the imagined possibility with reality, in a process calledinferential confusion.According to inference-based therapy, obsessional thinking occurs when the person replaces reality and real probabilities with imagined possibilities.The goal of inference-based therapy is to reorient clients towards trusting the senses and relating to reality in a normal, non-effortful way. Differences between normal and obsessional doubts are presented, and clients are encouraged to use their senses and reasoning as they do in non-obsessive–compulsive disorder situations.Research on Inference-Based Cognitive-Behavior Therapy (I-CBT) suggests it can lead to improvements for those with OCD.

A 2007Cochrane reviewfound that psychological interventions derived from CBT models, such as ERP, ACT, and IBT, were more effective than non-CBT interventions.Other forms of psychotherapy, such aspsychodynamicsandpsychoanalysis,may help in managing some aspects of the disorder. However, in 2007, theAmerican Psychiatric Association(APA) noted a lack ofcontrolled studiesshowing their efficacy, "in dealing with the core symptoms of OCD."Forbody-focused repetitive behaviors(BFRB), behavioral interventions such ashabit-reversal traininganddecouplingare recommended.

Psychotherapy in combination with psychiatric medication may be more effective than either option alone for individuals with severe OCD.ERP coupled with weight restoration and serotonin reuptake inhibitors has proven the most effective when treating OCD and an eating disorder simultaneously.

Medication

A blister pack of sertraline under the brand name Zoloft

The medications most frequently used to treat OCD are antidepressants, includingselective serotonin reuptake inhibitors(SSRIs) andserotonin–norepinephrine reuptake inhibitors(SNRIs).Sertralineandfluoxetineare effective in treating OCD for children and adolescents.

SSRIs help people with OCD by inhibiting the reabsorption of serotonin by the nerve cells after they carry messages from neurons tosynapse;thus, more serotonin is available to pass further messages between nearby nerve cells.

SSRIs are a second-line treatment of adult OCD with mild functional impairment, and as first-line treatment for those with moderate or severe impairment. In children, SSRIs can be considered as a second-line therapy in those with moderate to severe impairment, with close monitoring for psychiatric adverse effects.Patients treated with SSRIs are about twice as likely to respond to treatment as are those treated withplacebo,so this treatment is qualified as efficacious.Efficacy has been demonstrated both in short-term (6–24 weeks) treatment trials, and in discontinuation trials with durations of 28–52 weeks.

Clomipramine,a medication belonging to the class oftricyclic antidepressants,appears to work as well as SSRIs, but has a higher rate of side effects.

In 2006, theNational Institute for Health and Care Excellence(NICE) guidelines recommended augmentative second-generation (atypical)antipsychoticsfor treatment-resistant OCD.Atypical antipsychotics are not useful when used alone, and no evidence supports the use of first-generation antipsychotics.For OCD treatment specifically, there is tentative evidence forrisperidone,and insufficient evidence forolanzapine.Quetiapineis no better than placebo with regard to primary outcomes, but small effects were found in terms of Y-BOCS score. The efficacy of quetiapine and olanzapine are limited by an insufficient number of studies.A 2014 review article found two studies that indicated thataripiprazolewas "effective in the short-term", and found that "[t]here was a small effect-size for risperidone or antipsychotics in general in the short-term"; however, the study authors found "no evidence for the effectiveness of quetiapine or olanzapine in comparison to placebo."While quetiapine may be useful when used in addition to an SSRI/SNRI in treatment-resistant OCD, these drugs are often poorly tolerated, and have metabolic side effects that limit their use. A guideline by theAmerican Psychological Associationsuggested thatdextroamphetaminemay be considered by itself after more well-supported treatments have been attempted.

Procedures

Electroconvulsive therapy(ECT) has been found to have effectiveness in some severe and refractory cases.Transcranial magnetic stimulationhas shown to provide therapeutic benefits in alleviating symptoms.

Surgerymay be used as a last resort in people who do not improve with other treatments. In this procedure, a surgicallesionis made in an area of the brain (thecingulate cortex). In one study, 30% of participants benefitted significantly from this procedure.Deep brain stimulationandvagus nerve stimulationare possible surgical options that do not require destruction ofbrain tissue.However, because deep brain stimulation results in such an instant and intense change, individuals may experience identity challenges afterward.In the United States, theFood and Drug Administration(FDA) approved deep brain stimulation for the treatment of OCD under ahumanitarian device exemption,requiring that the procedure be performed only in a hospital with special qualifications to do so.

In the United States,psychosurgeryfor OCD is a treatment of last resort, and will not be performed until the person has failed several attempts at medication (at the full dosage) with augmentation, and many months of intensivecognitive behavioral therapywith exposure and ritual/response prevention.Likewise, in the United Kingdom, psychosurgery cannot be performed unless a course of treatment from a suitably qualified cognitive–behavioral therapist has been carried out.

Children

Therapeutic treatment may be effective in reducing ritual behaviors of OCD for children and adolescents.Similar to the treatment of adults with OCD, cognitive behavioral therapy stands as an effective and validated first line of treatment of OCD in children.Family involvement, in the form of behavioral observations and reports, is a key component to the success of such treatments.Parental interventions also provide positive reinforcement for a child who exhibits appropriate behaviors as alternatives to compulsive responses. In a recent meta-analysis of evidenced-based treatment of OCD in children, family-focused individual CBT was labeled as "probably efficacious," establishing it as one of the leading psychosocial treatments for youth with OCD.After one or two years of therapy, in which a child learns the nature of their obsession and acquires strategies for coping, they may acquire a larger circle of friends, exhibit less shyness, and become less self-critical.Trials have shown that children and adolescents with OCD should begin treatment with the combination of CBT with a selective serotonin reuptake inhibitor or CBT alone, rather than only an SSRI.

Although the known causes of OCD in younger age groups range from brain abnormalities to psychological preoccupations, life stress such as bullying and traumatic familial deaths may also contribute to childhood cases of OCD, and acknowledging these stressors can play a role in treating the disorder.

Prognosis

Quality of lifeis reduced across all domains in OCD. While psychological or pharmacological treatment can lead to a reduction of OCD symptoms and an increase in reported quality of life, symptoms may persist at moderate levels even following adequate treatment courses, and completely symptom-free periods are uncommon.In pediatric OCD, around 40% still have the disorder in adulthood, and around 40% qualify forremission.The risk of having at least one comorbid personality disorder in OCD is 52%, which is the highest among anxiety disorders and greatly impacts its management and prognosis.

Epidemiology

Further information:Delayed-maturation theory of obsessive–compulsive disorder

Age-standardizeddisability-adjusted life yearestimated rates for obsessive-compulsive disorder per 100,000 inhabitants in 2004

no data

<45

45–52.5

52.5–60

60–67.5

67.5–75

75–82.5

82.5–90

90–97.5

97.5–105

105–112.5

112.5–120

>120

Obsessive–compulsive disorder affects about 2.3% of people at some point in their life, with the yearly rate about 1.2%.OCD occurs worldwide.It is unusual for symptoms to begin after the age of 35 and half of people develop problems before 20.Males and females are affected about equally.However, there is an earlier age for onset for males than females.

History

Plutarch,anancient Greek philosopherandhistorian,describesan ancient Roman man who possibly hadscrupulosity,which could be a symptom of OCD orOCPD.This man is described as "turning pale under hiscrown of flowers,"praying with a" faltering voice, "and scattering" incense with trembling hands. "

In the 7th century AD,John Climacusrecords an instance of a youngmonkplagued by constant and overwhelming "temptations toblasphemy"consulting an older monk, who told him:" My son, I take upon myself all the sins which these temptations have led you, or may lead you, to commit. All I require of you is that for the future you pay no attention to them whatsoever. "The Cloud of Unknowing,aChristianmystical text from the late 14th century, recommends dealing with recurring obsessions by attempting to ignore them, and, if that fails, to "cower under them like a poor wretch and a coward overcome in battle, and reckon it to be a waste of your time for you to strive any longer against them", a technique now known asemotional flooding.

Abu Zayd Al-Balkhi,the 9th century Islamic polymath, was likely the first to classify OCD into different types and pioneercognitive behavioral therapy,in a fashion unique to his era and which was not popular in Greek medicine.In his medical treatise entitledSustenance of the Body and Soul,Al-Balkhi describes obsessions particular to the disorder as "Annoying thoughts that are not real. These intrusive thoughts prevent enjoying life, and performing daily activities. They affect concentration and interfere with ability to carry out different tasks."As treatment, Al-Balkhi suggests treating obsessive thoughts with positive thoughts and mind-based therapy.

From the 14th to the 16th century in Europe, it was believed that people who experienced blasphemous, sexual or other obsessive thoughts werepossessedby thedevil.Based on this reasoning, treatment involved banishing the "evil" from the "possessed" person throughexorcism.The vast majority of people who thought that they were possessed by the devil did not have hallucinations or other "spectacular symptoms" but "complained of anxiety, religious fears, and evil thoughts."In 1584, a woman fromKent,England,named Mrs. Davie, described by ajustice of the peaceas "a good wife", was nearlyburned at the stakeafter she confessed that she experienced constant, unwanted urges to murder her family.

The English termobsessive–compulsivearose as a translation ofGermanZwangsvorstellung(obsession) used in the first conceptions of OCD byKarl Westphal.Westphal's description went on to influencePierre Janet,who further documented features of OCD.In the early 1910s,Sigmund Freudattributed obsessive–compulsive behavior to unconscious conflicts that manifest as symptoms.Freud describes the clinical history of a typical case of "touching phobia" as starting in early childhood, when the person has a strong desire to touch an item. In response, the person develops an "external prohibition" against this type of touching. However, this "prohibition does not succeed in abolishing" the desire to touch; all it can do is repress the desire and "force it into the unconscious."Freudianpsychoanalysisremained the dominant treatment for OCD until the mid-1980s, even though medicinal and therapeutic treatments were known and available, because it was widely thought that these treatments would be detrimental to the effectiveness of thepsychotherapy.In the mid-1980s, this approach changed, and practitioners began treating OCD primarily with medicine and practical therapy rather than through psychoanalysis.

One of the first successful treatments of OCD,exposure and response prevention,emerged during the 1960s, when psychologistVic Meyerexposed two hospitalized patients to anxiety-inducing situations while preventing them from performing any compulsions. Eventually, both patients' anxiety level dropped to manageable levels. Meyer devised this procedure from his analysis offear extinguishmentin animals viaflooding.The success of ERP clinically and scientifically has been summarized as "spectacular" by prominent OCD researcherStanley Rachmandecades following Meyer's creation of the method.

In 1967, psychiatristJuan José López-Iborreported that the drugclomipraminewas effective in treating OCD. Many reports of its success in treatment followed, and several studies had confirmed its effectiveness by the 1980s.However, clomipramine was subsequently displaced by newSSRIsdeveloped in the 1970s, such asfluoxetineandsertraline,which were shown to have fewer side effects.

Obsessive–compulsive symptoms worsened during the early stages of theCOVID-19 pandemic,particularly for individuals with contamination-related OCD.

Notable cases

John Bunyan(1628–1688), the author ofThe Pilgrim's Progress,displayed symptoms of OCD (which had not yet been named). During the most severe period of his condition, he would mutter the same phrase over and over again to himself while rocking back and forth.He later described his obsessions in his autobiographyGrace Abounding to the Chief of Sinners,stating, "These things may seem ridiculous to others, even as ridiculous as they were in themselves, but to me they were the most tormenting cogitations."He wrote two pamphlets advising those with similar anxieties.In one of them, he warns against indulging in compulsions: "Have care of putting off your trouble of spirit in the wrong way: by promising to reform yourself and lead a new life, by your performances or duties".

British poet, essayist andlexicographerSamuel Johnson(1709–1784) also had OCD. He had elaborate rituals for crossing the thresholds of doorways, and repeatedly walked up and down staircases counting the steps.He would touch every post on the street as he walked past, only step in the middle of paving stones, and repeatedly perform tasks as though they had not been done properly the first time.

The "Rat Man",real name Ernst Lanzer, a patient ofSigmund Freud,suffered from what was then called "obsessional neurosis". Lanzer's illness was characterised most famously by a pattern of distressing intrusive thoughts in which he feared that his father or a female friend would be subjected to a purported Chinese method oftorturein which rats would be encouraged to gnaw their way out of a victim's body by a hot poker.

American aviator and filmmakerHoward Hughesis known to have had OCD, primarily an obsessive fear of germs and contamination.Friends of Hughes have also mentioned his obsession with minor flaws in clothing.This was conveyed inThe Aviator(2004), a film biography of Hughes.

English singer-songwriterGeorge Ezrahas openly spoken about his life-long struggle with OCD, particularlyprimarily obsessional obsessive–compulsive disorder(Pure O).

Swedish climate activistGreta Thunbergis also known to have OCD, among other mental health conditions.

American actorJames Spaderhas also spoken about his OCD. In 2014, when interviewed forRolling Stonehe said: "I'm obsessive-compulsive. I have very, very strong obsessive-compulsive issues. I'm very particular.... It's very hard for me, you know? It makes you very addictive in behavior, because routine and ritual become entrenched. But in work, it manifests itself in obsessive attention to detail and fixation. It serves my work very well: Things don't slip by. But I'm not very easygoing.

In 2022 the president of ChileGabriel Boricstated that he had OCD, saying: "I have an obsessive–compulsive disorder that's completely under control. Thank God I've been able to undergo treatment and it doesn't make me unable to carry out my responsibilities as the President of the Republic."

In a documentary released in 2023,David Beckhamshared details about his compelling cleaning rituals, need for symmetry in the fridge, and the impact of OCD on his life.

Society and culture

Thisribbonrepresentstrichotillomaniaand other body-focused repetitive behaviors.

Art, entertainment and media

Movies and television shows may portray idealized or incomplete representations of disorders such as OCD.Compassionate and accurate literary and on-screen depictions may help counteract the potentialstigmaassociated with an OCD diagnosis, and lead to increased public awareness, understanding and sympathy for such disorders.

• The play and film adaptations ofThe Odd Couplebased around the character of Felix, who shows some of the common symptoms of OCD.
• In the filmAs Good as It Gets(1997), actorJack Nicholsonportrays a man with OCD who performs ritualistic behaviors that disrupt his life.
• The filmMatchstick Men(2003) portrays a con man named Roy (Nicolas Cage) with OCD who opens and closes doors three times while counting aloud before he can walk through them.
• In the television seriesMonk(2002–2009), the titular characterAdrian Monkfears both human contact and dirt.
• The one-man showThe Life and Slimes of Marc Summers(2016), a stage adaptation ofMarc Summers' 1999 memoir which recounts how OCD affected his entertainment career.
• In the novelTurtles All the Way Down(2017) byJohn Green,teenage main character Aza Holmes struggles with OCD that manifests as a fear of the human microbiome. Throughout the story, Aza repeatedly opens an unhealedcalluson her finger to drain out what she believes are pathogens. The novel is based on Green's own experiences with OCD. He explained thatTurtles All the Way Downis intended to show how "most people with chronic mental illnesses also live long, fulfilling lives".
• The British TV seriesPure(2019) starsCharly Cliveas a 24-year-old Marnie who is plagued by disturbing sexual thoughts, as a kind ofprimarily obsessional obsessive compulsive disorder.

Research

The naturally occurring sugarinositolhas been suggested as a treatment for OCD.

μ-Opioid receptoragonists, such ashydrocodoneandtramadol,may improve OCD symptoms.Administration of opioids may be contraindicated in individuals concurrently takingCYP2D6inhibitors such asfluoxetineandparoxetine.

Much research is devoted to the therapeutic potential of the agents that affect the release of the neurotransmitterglutamateor the binding to its receptors. These includeriluzole,memantine,gabapentin,N-acetylcysteine(NAC),topiramate,andlamotrigine.Research on the potential for other supplements, such asmilk thistle,to help with OCD and various neurological disorders, is ongoing.

Other animals

See also:Animal psychopathology § Obsessive compulsive disorder (OCD)

Advocacy

Many organizations and charities around the world advocate for the wellbeing of people with OCD, stigma reduction, research, and awareness. TheInternational OCD Foundation(IOCDF) is the largest 501(c)3 nonprofit organization dedicated to serving a broad community of individuals with OCD and related disorders, their family members and loved ones, and mental health professionals and researchers around the world. Since 1986, the IOCDF provides up-to-date education and resources, strengthens community engagement worldwide, delivers quality professional training to clinicians, and funds groundbreaking research.

See also

• Anxiety disorder
• Bipolar disorder
• Body dysmorphic disorder
• Compulsive hoarding
• Delusional disorder
• Hypochondriasis
• Major depressive disorder
• Obsessive–compulsive spectrum
• Tic disorder
• Body-focused repetitive behavior
  • Trichotillomania

External links

• National Institute Of Mental Health
• American Psychiatric Association
• APA Division 12 treatment page for obsessive-compulsive disorder
• Davis LJ (2008).Obsession: A History.University of Chicago Press.ISBN978-0-226-13782-7.