Wikipedia

Quetiapine

Quetiapine,sold under the brand nameSeroquelamong others, is anatypical antipsychoticmedication used for the treatment ofschizophrenia,bipolar disorder,andmajor depressive disorder.[11][12]Despite being widely used as asleep aid,the benefits of such use may not outweigh the risk of undesirable side effects.[13]It is taken orally.[11]

Quetiapine
Clinical data
Pronunciation/kwɪˈtaɪ.əpiːn/kwi-TY-ə-peen
Trade namesSeroquel, Seroquel Xr, others
AHFS/DrugsMonograph
MedlinePlusa698019
License data
Pregnancy
category
  • AU:B3
Routes of
administration		By mouth
Drug classAtypical antipsychotic
ATC code
Legal status
Legal status
Pharmacokineticdata
Bioavailability100%[6]
Protein binding83%[7]
MetabolismLivervia CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[10]
Eliminationhalf-life7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)[7][8]
ExcretionKidney(73%), feces (20%)[6][7][8][9]
Identifiers
  • 2-(2-(4-Dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.131.193Edit this at Wikidata
Chemical and physical data
FormulaC21H25N3O2S
Molar mass383.51g·mol−1
3D model (JSmol)
Solubility in water3.29 mg/mL (20 °C)
  • N\1=C(\c3c(Sc2c/1cccc2)cccc3)N4CCN(CCOCCO)CC4
  • InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2checkY
  • Key:URKOMYMAXPYINW-UHFFFAOYSA-NcheckY
(verify)

Common side effects includesedation,fatigue,weight gain,constipation,anddry mouth.[11]Other side effects includelow blood pressure with standing,seizures,aprolonged erection,high blood sugar,tardive dyskinesia,andneuroleptic malignant syndrome.[11]In older people withdementia,its use increases the risk of death.[11]Use in thethird trimesterofpregnancymay result in amovement disorderin the baby for some time after birth.[11]Quetiapine is believed to work by blocking a number of receptors, including those forserotoninanddopamine.[11]

Quetiapine was developed in 1985 and was approved for medical use in the United States in 1997.[4][11][14]It is available as ageneric medication.[15]In 2022, it was the 82nd most commonly prescribed medication in the United States, with more than 8million prescriptions.[16][17]It is on theWorld Health Organization's List of Essential Medicines.[18]

Medical uses

Quetiapine (Seroquel) 25 mg tablets, next toUS one-centcoin for comparison
Seroquel XR 150 mg tablet box

Quetiapine is primarily used to treat schizophrenia or bipolar disorder.[19]Quetiapine targets both positive and negative symptoms of schizophrenia.[20]

Schizophrenia

A 2013 Cochranereviewcompared quetiapine to typical antipsychotics:

Quetiapine compared to typical antipsychotics for schizophrenia[21]
Summary
Quetiapine may not differ from typicalantipsychoticsin the treatment ofpositive symptoms,general psychopathology, andnegative symptoms.However, it causes fewer adverse effects in terms of abnormalECG,extrapyramidaleffects, abnormal prolactin levels and weight gain.[21]

In a 2013 comparison of 15 antipsychotics in effectiveness in treating schizophrenia, quetiapine demonstrated standard effectiveness. It was 13–16% more effective thanziprasidone,chlorpromazine,andasenapineand approximately as effective ashaloperidolandaripiprazole.[22]

There is tentative evidence of the benefit of quetiapine versus placebo in schizophrenia; however, definitive conclusions are not possible due to the high rate of attrition in trials (greater than 50%) and the lack of data on economic outcomes, social functioning, or quality of life.[23]

It is debatable whether, as a class,typicaloratypical antipsychoticsare more effective.[24]Both have equal drop-out and symptom relapse rates when typicals are used at low to moderate dosages.[25]While quetiapine has lower rates of extrapyramidal side effects, there is greater sleepiness and rates of dry mouth.[23]

A Cochrane review comparing quetiapine to other atypical antipsychotic agents tentatively concluded that it may be less efficacious thanolanzapineandrisperidone;produce fewer movement related side effects thanpaliperidone,aripiprazole,ziprasidone,risperidone and olanzapine; and produce weight gain similar to risperidone,clozapineand aripiprazole. They concluded that it produces suicide attempt, suicide; death; QTc prolongation,low blood pressure;tachycardia;sedation;gynaecomastia;galactorrhoea,menstrual irregularityandwhite blood cell countat a rate similar to first generation antipsychotics.[26]

Bipolar disorder

In those withbipolar disorder,quetiapine is used to treat depressive episodes; acute manic episodes associated withbipolar I disorder(as either monotherapy or adjunct therapy tolithium;valproateorlamotrigine); acute mixed episodes; and maintenance treatment of bipolar I disorder (as adjunct therapy to lithium or divalproex).

Major depressive disorder

Quetiapine is effective when used by itself[12]and when used along with other medications inmajor depressive disorder(MDD).[12][27]However, sedation is often an undesirable side effect.[12]

In the United States,[8]the United Kingdom[28]and Australia (while not subsidised by the AustralianPharmaceutical Benefits Schemefor treatment of MDD), quetiapine is licensed for use as an add-on treatment in MDD.[29]

Alzheimer's disease

Quetiapine does not decrease agitation among people withAlzheimer's disease.Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[30]

Insomnia

The use of low doses of quetiapine forinsomnia,while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[31][32][33][34][35][36]A 2022 network meta-analysis of 154 double-blind, randomized controlled trials of drug therapies vs. placebo for insomnia in adults found that quetiapine did not demonstrate any short-term benefits in sleep quality. Quetiapine, specifically, had aneffect size(standardized mean difference) againstplacebofor treatment of insomnia of 0.05 (95%CITooltip confidence interval–1.21 to 1.11) at 4weeks of treatment, with thecertainty of evidencerated as very low.[37]Doses of quetiapine used for insomnia have ranged from 12.5 to 800mg, with low doses of 25 to 200mg being the most typical.[38][31][32]Regardless of the dose used, some of the more serious adverse effects may still possibly occur at the lower dosing ranges, such asdyslipidemiaandneutropenia.[39][40]These safety concerns at low doses are corroborated by Danish observational studies that showed use of specifically low-dose quetiapine (prescriptions filled for tablet strengths >50 mg were excluded) was associated with an increased risk of major cardiovascular events as compared to use ofZ-drugs,with most of the risk being driven by cardiovascular death.[41]Laboratory data from an unpublished analysis of the same cohort also support the lack of dose-dependency of metabolic side effects, as new use of low-dose quetiapine was associated with a risk of increased fasting triglycerides at 1-year follow-up.[42]

Others

It is sometimes usedoff-label,often as an augmentation agent, to treat conditions such asTourette syndrome,[43]musical hallucinations[44]andanxiety disorders.[45]

Quetiapine andclozapineare the most widely used medications for the treatment ofParkinson's diseasepsychosis due to their relatively low extrapyramidal side-effect liability.[46]Owing to the risks associated with clozapine (e.g. agranulocytosis, diabetes mellitus, etc.), clinicians often attempt treatment with quetiapine first, although the evidence to support quetiapine's use for this indication is significantly weaker than that of clozapine.[47][48]

Adverse effects

Sources for incidence lists:[6][8][28][29][48][49]

Very common (>10% incidence) adverse effects
  • Dry mouth
  • Dizziness
  • Headache
  • Somnolence(drowsiness; of 15 antipsychotics quetiapine causes the 5th most sedation. Extended release (XR) formulations tend to produce less sedation, dose-by-dose, than the immediate release formulations.)[22]
Common (1–10% incidence) adverse effects
Rare (<1% incidence) adverse effects
  • Neuroleptic malignant syndromea rare and potentially fatal complication of antipsychotic drug treatment. It is characterised by the following symptoms: tremor, rigidity, hyperthermia, tachycardia, mental status changes (e.g. confusion), etc.
  • Tardive dyskinesia.A rare and often irreversible neurological condition characterised by involuntary movements of the face, tongue, lips and rest of the body. Most commonly occurs after prolonged treatment with antipsychotics. It is believed to be particularly uncommon with atypical antipsychotics, especially quetiapine and clozapine[29]

Both typical and atypical antipsychotics can causetardive dyskinesia.[50]According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.[50]Although quetiapine and clozapine are atypical antipsychotics, switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.[51]

Weight gain can be a problem for some, with quetiapine causing more weight gain thanfluphenazine,haloperidol,loxapine,molindone,olanzapine,pimozide,risperidone,thioridazine,thiothixene,trifluoperazine,andziprasidone,but less thanchlorpromazine,clozapine,perphenazine,andsertindole.[52]

As with some other anti-psychotics, quetiapine may lower theseizure threshold,[53]and should be taken with caution in combination with drugs such asbupropion.

Discontinuation

TheBritish National Formularyrecommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse.[54]Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite.[55]Other symptoms may include restlessness, increased sweating, and trouble sleeping.[55]Less commonly there may be a feeling of the world spinning, numbness, or muscle pains.[55]Symptoms generally resolve after a short period of time.[55]

There is tentative evidence that discontinuation of antipsychotics can result in psychosis.[56]It may also result in reoccurrence of the condition that is being treated.[57]Rarely tardive dyskinesia can occur when the medication is stopped.[55]

Pregnancy and lactation

Placental exposure is least for quetiapine compared to other atypical antipsychotics.[48]The evidence is insufficient to rule out any risk to the foetus but available data suggests it is unlikely to result in any major foetal malformations.[7][9][49]It is secreted in breast milk and hence quetiapine-treated mothers are advised not to breastfeed.[7][9][49]

Abuse potential

In contrast to most other antipsychotic drugs, which tend to be somewhat aversive and often show problems with patient compliance with prescribed medication regimes, quetiapine is sometimes associated withdrug misuseand abuse potential, for its hypnotic and sedative effects. It has a limited potential for misuse, usually only in individuals with a history of polysubstance abuse and/or mental illness, and especially in those incarcerated in prisons or secure psychiatric facilities where access to alternative intoxicants is more limited. To a significantly greater extent than other atypical antipsychotic drugs, quetiapine was found to be associated with drug-seeking behaviors, and to have standardised street prices and slang terms associated with it, either by itself or in combination with other drugs (such as "Q-ball" for the intravenous injection of quetiapine mixed withcocaine). The pharmacological basis for this distinction from other second generation antipsychotic drugs is unclear, though it has been suggested that quetiapine's comparatively lower dopamine receptor affinity and strong antihistamine activity might mean it could be regarded as more similar to sedatingantihistaminesin this context. While these issues have not been regarded as sufficient cause for placing quetiapine under increased legal controls, prescribers have been urged to show caution when prescribing quetiapine to individuals with characteristics that might place them at increased risk for drug misuse.[58][59][60][61][62]

Overdose

Most instances of acute overdosage result in only sedation, hypotension and tachycardia, but cardiac arrhythmia, coma and death have occurred in adults. Serum or plasma quetiapine concentrations are usually in the 1–10 mg/L range in overdose survivors, while postmortem blood levels of 10–25 mg/L are generally observed in fatal cases.[63]Non-toxic levels in postmortem blood extend to around 0.8 mg/kg, but toxic levels in postmortem blood can begin at 0.35 mg/kg.[64][65]

Pharmacology

Pharmacodynamics

See also:Atypical antipsychotic § Pharmacodynamics,andAntipsychotic § Comparison of medications
Quetiapine (and metabolite)[66][67]
Site QTP NQTP Action Ref
SERTTooltip Serotonin transporter >10,000 927 Blocker [67]
NETTooltip Norepinephrine transporter >10,000 58 Blocker [67]
DATTooltip Dopamine transporter >10,000 >10,000 ND [67]
5-HT1A 320–432 45 Partial agonist [67][68]
5-HT1B 1,109–2,050 1,117 ND [67][68]
5-HT1D >10,000 249 ND [67][68]
5-HT1E 1,250–2,402 97 ND [67][68]
5-HT1F 2,240 ND ND [68]
5-HT2A 96–101 48 Antagonist [67][68]
5-HT2B ND 14 Antagonist [67]
5-HT2C 2,502 107 Antagonist [67]
5-HT3 >10,000 394 Antagonist [67]
5-HT4 ND ND ND ND
5-HT5A 3,120 768 ND [67]
5-HT6 1,865 503 Antagonist [67]
5-HT7 307 76 Antagonist [67]
α1A 22 144 Antagonist [67]
α1B 39 95 Antagonist [67]
α2A 2,230–3,630 237 Antagonist [67][68]
α2B 90–747 378 Antagonist [67][68]
α2C 28.7–350 736 Antagonist [67][68]
β1 >10,000 >10,000 ND [67][68]
β2 >10,000 >10,000 ND [67][68]
D1 712 214 Antagonist [67]
D2 245 196 Antagonist [67]
D2L 700 ND Antagonist [68]
D2S 390 ND Antagonist [68]
D3 340–483 567 Antagonist [67][68]
D4 1,202 1,297 Antagonist [67]
D4.2 1,600 ND Antagonist [68]
D5 1,738 1,419 Antagonist [67]
H1 2.2–11 3.5 Antagonist [67]
H2 >10,000 298 Antagonist [67]
H3 >10,000 >10,000 ND [67]
H4 >10,000 1,660 ND [67]
M1 858 39 Antagonist [67]
M2 1,339 453 ND [67]
M3 >10,000 23 Antagonist [67]
M4 542 110 ND [67]
M5 1,942 23 Antagonist [67]
σ1 220–3,651 >10,000 ND [67][68]
σ2 1,344 1,050 ND [67]
NMDA
(PCP)		 >10,000 ND Antagonist [67]
VDCCTooltip Voltage-dependent calcium channel >10,000 ND ND [67][68]
hERGTooltip Human Ether-à-go-go-Related Gene ND >10,000
(IC50Tooltip Half-maximal inhibitory concentration)		 ND [67]
Values are Ki(nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site. All data are for human cloned proteins, except σ1(guinea pig), σ2(rat), andVDCC(rat).[67][68]

Quetiapine has the following pharmacological actions:[69][70][71][72][4][73][74][75]

This means quetiapine is adopamine,serotonin,andadrenergicantagonist, and a potentantihistaminewith someanticholinergicproperties.[76]Quetiapine binds strongly to serotonin receptors; the drug acts aspartial agonistat 5-HT1Areceptors.[77]Serial PET scans evaluating the D2receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2receptor.[78]Theoretically, this allows for normal physiological surges of dopamine to elicit normal effects in areas such as thenigrostriatalandtuberoinfundibularpathways, thus minimizing the risk of side-effects such as pseudo-parkinsonism as well as elevations inprolactin.[79]Some of the antagonized receptors (serotonin, norepinephrine) are actuallyautoreceptorswhose blockade tends to increase the release of neurotransmitters.

At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) andα1-adrenergicblocker. When the dose is increased, quetiapine activates the adrenergic system and binds strongly to serotonin receptors andautoreceptors.At high doses, quetiapine starts blocking significant amounts of dopamine receptors.[70][80]Due to the drug's sedating H1activity, it is often prescribed at low doses for insomnia. While some feel that low doses of drugs with antihistamine effects like quetiapine andmirtazapineare safer than drugs associated with physical dependency or other risk factors, concern has been raised by some professionals that off-label prescribing has become too widespread due to underappreciated hazards.[81]

When treating schizophrenia, antagonism of D2receptor by quetiapine in the mesolimbic pathway relieves positive symptoms and antagonism of the 5-HT2Areceptor in the frontal cortex of the brain may relieve negative symptoms and reduce severity of psychotic episodes.[20][82][83]Quetiapine has fewer extrapyramidal side effects and is less likely to cause hyperprolactinemia when compared to other drugs used to treat schizophrenia, so is used as a first line treatment.[84][85]

Pharmacokinetics

Peak levels of quetiapine occur 1.5 hours after a dose.[86]Theplasma protein bindingof quetiapine is 83%.[86]The majoractive metaboliteof quetiapine isnorquetiapine(N-desalkylquetiapine).[67]Quetiapine has anelimination half-lifeof 6 or 7 hours.[86][7][8]Its metabolite, norquetiapine, has a half-life of 9 to 12 hours.[7][8]Quetiapine isexcretedprimarily via thekidneys(73%) and infeces(20%) after hepatic metabolism, the remainder (1%) is excreted as the drug in its unmetabolized form.[82][86]

Skeletal formula of norquetiapine

Chemistry

Quetiapine is atetracyclic compoundand is closely related structurally toclozapine,olanzapine,loxapine,and other tetracyclic antipsychotics.

Synthesis

The synthesis of quetiapine begins with a dibenzothiazepinone. Thelactamis first treated withphosphoryl chlorideto produce adibenzothiazepine.Anucleophilic substitutionis used to introduce the sidechain.[87]

History

Sustained-release

AstraZeneca submitted anew drug applicationfor asustained-releaseversion of quetiapine in the United States, Canada, and the European Union in the second half of 2006 for treatment of schizophrenia.[88][89]

In May 2007, the US FDA approved Seroquel XR for acute treatment of schizophrenia.[90]During its 2007 Q2 earnings conference, AstraZeneca announced plans to launch Seroquel XR in the U.S. during August 2007.[91]However, Seroquel XR has become available in U.S. pharmacies only after the FDA approved Seroquel XR for use as maintenance treatment for schizophrenia, in addition to acute treatment of the illness, on 16 November 2007.[92]The company has not provided a reason for the delay of Seroquel XR's launch.

Health Canadaapproved sale of Seroquel XR on 27 September 2007.[93]

In October 2008, the FDA approved Seroquel XR for the treatment of bipolar depression and bipolar mania.

In December 2008,Biovailannounced that the FDA had accepted the company's ANDA to market its own version of sustained-release quetiapine.[94]Biovail's sustained-release tablets will compete with AstraZeneca's Seroquel XR.

In December 2008, AstraZeneca notified shareholders that the FDA had asked for additional information on the company's application to expand the use of sustained-release quetiapine for treatment of depression.[95]

Society and culture

Regulatory status

In the United States, theFood and Drug Administration(FDA) has approved quetiapine for the treatment ofschizophreniaand of acutemanicepisodes associated withbipolar disorder(bipolar mania) and for treatment ofbipolar depression.[96]In 2009, quetiapine XR was approved as adjunctive treatment of major depressive disorder.[97]

Quetiapine received its initial approval from the US FDA for the treatment of schizophrenia in 1997.[4][98]In 2004, it received its second indication for the treatment of mania-associated bipolar disorder.[99]In 2007 and 2008, studies were conducted on quetiapine's efficacy in treating generalized anxiety disorder and major depression.

Patent protection for the product ended in 2012; however, in a number of regions, the long-acting version remained under patent until 2017.[100]

Lawsuits

In April 2010, the U. S. Department of Justice fined AstraZeneca $520 million for the company's aggressive marketing of Seroquel foroff-label uses.[96]According to the Department of Justice, "the company recruited doctors to serve as authors of articles that were ghostwritten by medical literature companies and about studies the doctors in question did not conduct. AstraZeneca then used those studies and articles as the basis for promotional messages about unapproved uses of Seroquel."[96]

Multiple lawsuits have been filed in relation to quetiapine's side-effects, in particular,diabetes.[101][102][103][104]

Approximately 10,000[105]lawsuits[106]have been filed against AstraZeneca, alleging that quetiapine caused problems ranging from slurred speech and chronic insomnia to deaths.

Controversy

In 2004, a young man namedDan Markingsoncommitted suicide in a controversial Seroquel clinical trial at the University of Minnesota while under an involuntary commitment order.[107]A group of University of Minnesota bioethicists charged that the trial involved an alarming number of ethical violations.[108]

Nurofen Plus tampering case

In August 2011, the UK'sMedicines and Healthcare products Regulatory Agency(MHRA) issued a class-4 drug alert following reports that some batches ofNurofen pluscontained Seroquel XL tablets instead.[109]

Following the issue of the Class-4 Drug Alert, Reckitt Benckiser (UK) Ltd received further reports of rogue blister strips in cartons of two additional batches of Nurofen Plus tablets. One of the new batches contained Seroquel XL 50 mg tablets and one contained the Pfizer productNeurontin100 mg capsules.

Following discussions with the MHRA's Defective Medicines Report Centre (DMRC), Reckitt Benckiser (UK) Ltd decided to recall all remaining unexpired stock of Nurofen Plus tablets in any pack size, leading to a Class-1 Drug Alert.[110]The contamination was later traced to in-store tampering by a customer.[111]

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