E3 ubiquitin-protein ligase RFWD2is anenzymethat in humans is encoded by theRFWD2gene.[5][6]

COP1
Available structures
PDBOrtholog search:PDBeRCSB
Identifiers
AliasesCOP1,RNF200, ring finger and WD repeat domain 2, E3 ubiquitin ligase, RFWD2, COP1 E3 ubiquitin ligase, FAP78, CFAP78
External IDsOMIM:608067;MGI:1347046;HomoloGene:115565;GeneCards:COP1;OMA:COP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001740
NM_001286644
NM_022457

NM_011931
NM_001360878

RefSeq (protein)

NP_001001740
NP_001273573
NP_071902

NP_036061
NP_001347807

Location (UCSC)Chr 1: 175.94 – 176.21 MbChr 1: 159.06 – 159.18 Mb
PubMedsearch[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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RFWD2 has been shown tointeractwithC-jun.[7][8]

References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000143207Ensembl,May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000040782Ensembl,May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Wang H, Kang D, Deng XW, Wei N (Sep 1999)."Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1".Curr Biol.9(13): 711–4.Bibcode:1999CBio....9..711W.doi:10.1016/S0960-9822(99)80314-5.PMID10395541.S2CID2822539.
  6. ^"Entrez Gene: RFWD2 ring finger and WD repeat domain 2".
  7. ^Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (Feb 2004)."Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase"(PDF).Science.303(5662): 1371–4.Bibcode:2004Sci...303.1371W.doi:10.1126/science.1093549.PMID14739464.S2CID40501515.
  8. ^Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (May 2003)."Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity".J. Biol. Chem.278(22): 19682–90.doi:10.1074/jbc.M212681200.hdl:2434/518351.PMID12615916.

Further reading

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