60S ribosomal protein L8

60S ribosomal protein L8is aproteinthat in humans is encoded by theRPL8gene.

RPL8
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4CCM,4CCN,4CCO,4UG0,4V6X,5AJ0,4D67,3J7Q,4Y3O,4UJC,3J7R,4D5Y,4UJE,4UJD,3J7P,3J7O,3J92,4V5Z
Identifiers
Aliases	RPL8,L8, ribosomal protein L8
External IDs	OMIM:604177;MGI:1350927;HomoloGene:32141;GeneCards:RPL8;OMA:RPL8 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.3 Start 144,789,765bp End 144,792,587bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D3 Start 76,788,278bp End 76,790,514bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in gonad ovary left ovary trachea right ovary thymus mucosa of transverse colon ventricular zone Pituitary Gland skin of leg Top expressed in primitive streak hair follicle abdominal wall efferent ductule transitional epithelium of urinary bladder medial ganglionic eminence endothelial cell of lymphatic vessel mandibular prominence maxillary prominence condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding structural constituent of ribosome RNA binding 5.8S rRNA binding Cellular component cytosol ribosome membrane focal adhesion large ribosomal subunit intracellular anatomical structure cytoplasm cytosolic large ribosomal subunit postsynaptic density polysomal ribosome synapse postsynapse Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cellular response to nerve growth factor stimulus Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6132 26961 Ensembl ENSG00000161016 ENSMUSG00000003970 UniProt P62917 P62918 RefSeq (mRNA) NM_000973 NM_033301 NM_001317771 NM_001317782 NM_012053 RefSeq (protein) NP_000964 NP_001304700 NP_001304711 NP_150644 NP_036183 Location (UCSC) Chr 8: 144.79 – 144.79 Mb Chr 15: 76.79 – 76.79 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes,theorganellesthat catalyzeprotein synthesis,consist of a small40Ssubunit and a large60Ssubunit. Together these subunits are composed of 4RNAspecies and approximately 80 structurally distinct proteins. This gene encodes aribosomal proteinthat is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in thecytoplasm.In rat, the protein associates with the5.8S rRNA,very likely participates in the binding ofaminoacyl-tRNA,and is a constituent of theelongation factor 2-binding site at the ribosomal subunit interface.Alternatively splicedtranscript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenesof this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
• Uhlein M, Weglöhner W, Urlaub H, Wittmann-Liebold B (1998)."Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies".Biochem. J.331(2): 423–30.doi:10.1042/bj3310423.PMC1219371.PMID9531480.
• Andersen JS, Lyon CE, Fox AH, et al. (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002)."The human ribosomal protein genes: sequencing and comparative analysis of 73 genes".Genome Res.12(3): 379–90.doi:10.1101/gr.214202.PMC155282.PMID11875025.
• Brezillon S, Lannoy V, Franssen JD, et al. (2003)."Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8".J. Biol. Chem.278(2): 776–83.doi:10.1074/jbc.M206396200.PMID12401809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing".J. Protein Chem.22(3): 249–58.doi:10.1023/A:1025068419698.PMID12962325.S2CID10710245.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF- Alpha /NF-kappa B signal transduction pathway".Nat. Cell Biol.6(2): 97–105.doi:10.1038/ncb1086.PMID14743216.S2CID11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".Nat. Biotechnol.23(1): 94–101.doi:10.1038/nbt1046.PMID15592455.S2CID7200157.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433(7021): 77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID15635413.S2CID4344740.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome".Cell.122(6): 957–68.doi:10.1016/j.cell.2005.08.029.hdl:11858/00-001M-0000-0010-8592-0.PMID16169070.S2CID8235923.

External links

• Overview of all the structural information available in thePDBforUniProt:P62917(60S ribosomal protein L8) at thePDBe-KB.