TAOK1

Serine/threonine-protein kinase TAO1is anenzymethat in humans is encoded by theTAOK1gene.

TAOK1
Identifiers
Aliases	TAOK1,KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAO kinase 1, DDIB
External IDs	OMIM:610266;MGI:1914490;HomoloGene:27041;GeneCards:TAOK1;OMA:TAOK1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 29,390,363bp End 29,551,903bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 77,419,988bp End 77,498,641bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in corpus callosum globus pallidus internal globus pallidus ventral tegmental area subthalamic nucleus sural nerve pars compacta inferior ganglion of vagus nerve Pons external globus pallidus Top expressed in ventromedial nucleus lateral septal nucleus Amygdala lateral geniculate nucleus olfactory tubercle anterior amygdaloid area mammillary body habenula inferior colliculi globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase activity Alpha -tubulin binding protein serine/threonine kinase activator activity tau protein binding beta-tubulin binding tau-protein kinase activity Cellular component cytoplasm cytosol extracellular exosome nucleus microtubule cytoskeleton perinuclear region of cytoplasm Biological process phosphorylation execution phase of apoptosis positive regulation of JNK cascade cellular response to DNA damage stimulus protein phosphorylation spindle checkpoint signaling regulation of cytoskeleton organization DNA repair positive regulation of stress-activated MAPK cascade apoptotic process sister chromatid cohesion MAPK cascade regulation of mitotic cell cycle nervous system development regulation of apoptotic process microtubule cytoskeleton organization negative regulation of microtubule depolymerization mitotic G2 DNA damage checkpoint signaling signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of actin cytoskeleton organization protein autophosphorylation neuron cellular homeostasis regulation of microtubule cytoskeleton organization positive regulation of protein acetylation Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 57551 216965 Ensembl ENSG00000160551 ENSMUSG00000017291 UniProt Q7L7X3 Q5F2E8 RefSeq (mRNA) NM_020791 NM_025142 NM_144825 NM_001364133 NM_001364134 RefSeq (protein) NP_065842 NP_079418 NP_659074 NP_001351062 NP_001351063 Location (UCSC) Chr 17: 29.39 – 29.55 Mb Chr 11: 77.42 – 77.5 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

Mutations of the TAOK1 gene causedevelopmental delay with or without intellectual impairment or behavioral abnormalities(DDIB), a condition first described in 2019.

Further reading

• Hutchison M, Berman KS, Cobb MH (1998)."Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades".J. Biol. Chem.273(44): 28625–32.doi:10.1074/jbc.273.44.28625.PMID9786855.
• Chen Z, Hutchison M, Cobb MH (1999)."Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain".J. Biol. Chem.274(40): 28803–7.doi:10.1074/jbc.274.40.28803.PMID10497253.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000)."Shotgun sequencing of the human transcriptome with ORF expressed sequence tags".Proc. Natl. Acad. Sci. U.S.A.97(7): 3491–6.Bibcode:2000PNAS...97.3491D.doi:10.1073/pnas.97.7.3491.PMC16267.PMID10737800.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants".Mol. Vis.8:205–20.PMID12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Yustein JT, Xia L, Kahlenburg JM, et al. (2003)."Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38".Oncogene.22(40): 6129–41.doi:10.1038/sj.onc.1206605.PMID13679851.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Lizcano JM, Göransson O, Toth R, et al. (2005)."LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1".EMBO J.23(4): 833–43.doi:10.1038/sj.emboj.7600110.PMC381014.PMID14976552.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101(33): 12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC514446.PMID15302935.
• Zihni C, Mitsopoulos C, Tavares IA, et al. (2006)."Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1".J. Biol. Chem.281(11): 7317–23.doi:10.1074/jbc.M513769200.PMID16407310.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".Nat. Biotechnol.24(10): 1285–92.doi:10.1038/nbt1240.PMID16964243.S2CID14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127(3): 635–48.doi:10.1016/j.cell.2006.09.026.PMID17081983.S2CID7827573.
• Raman M, Earnest S, Zhang K, et al. (2007)."TAO kinases mediate activation of p38 in response to DNA damage".EMBO J.26(8): 2005–14.doi:10.1038/sj.emboj.7601668.PMC1852793.PMID17396146.
• Draviam VM, Stegmeier F, Nalepa G, et al. (2007). "A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling".Nat. Cell Biol.9(5): 556–64.doi:10.1038/ncb1569.PMID17417629.S2CID34976750.