TLL1

TLL1
Available structures
PDB	Ortholog search:PDBeRCSB
List of PDB id codes
	3EDI
Identifiers
Aliases	TLL1,ASD6, TLL, tolloid like 1
External IDs	OMIM:606742;MGI:106923;HomoloGene:49202;GeneCards:TLL1;OMA:TLL1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	166,104,457bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	64,659,305bp
RNA expressionpattern
	Top expressed in
	secondary oocyte; ; gonad; ; testicle; ; cerebellar cortex; ; cerebellar hemisphere; ; epithelium of colon; ; right hemisphere of cerebellum; ; Achilles tendon; ; gallbladder; ; smooth muscle tissue;
	Top expressed in
	muscular part of interventricular septum; ; cardiac muscle tissue of interventricular septum; ; aorticopulmonary septum; ; vein; ; endocardium of atrium; ; interatrial septum; ; septum primum; ; endocardium of right atrium; ; zygote; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; serine-type endopeptidase activity;
Cellular component	extracellular region;
Biological process	multicellular organism development; skeletal system development; cell differentiation; extracellular matrix disassembly; proteolysis;
	Sources:Amigo/QuickGO
Orthologs
	7092
	21892
	ENSG00000038295
	ENSMUSG00000053626
	O43897
	Q62381
	NM_001204760; NM_012464
	NM_009390
	NP_001191689; NP_036596
	NP_033416
	Wikidata
View/Edit Human	View/Edit Mouse

Tolloid-like protein 1is aproteinthat in humans is encoded by theTLL1gene.^[5]^[6]

This gene encodes anastacin-like zinc-dependentmetalloproteaseand is a subfamily member of themetzincinfamily. A similar protein in mice is required during heart development and specifically processesprocollagenC-propeptides andchordinat similar cleavage sites.^[6]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000038295–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000053626–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19".Cytogenet Cell Genet.86(1): 64–65.doi:10.1159/000015412.PMID 10516436.S2CID 42081614.
^^a ^b"Entrez Gene: TLL1 tolloid-like 1".

Takahara K, Brevard R, Hoffman GG, et al. (1997). "Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1".Genomics.34(2): 157–165.doi:10.1006/geno.1996.0260.PMID 8661043.
Scott IC, Blitz IL, Pappano WN, et al. (1999)."Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis".Dev. Biol.213(2): 283–300.doi:10.1006/dbio.1999.9383.PMID 10479448.
Scott IC, Imamura Y, Pappano WN, et al. (2000)."Bone morphogenetic protein-1 processes probiglycan".J. Biol. Chem.275(39): 30504–30511.doi:10.1074/jbc.M004846200.PMID 10896944.
Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001)."Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures".J. Biol. Chem.276(25): 22537–22543.doi:10.1074/jbc.M102352200.PMID 11313359.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–16903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–45.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–2127.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.
Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006)."Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains".J. Biol. Chem.281(16): 10786–10798.doi:10.1074/jbc.M511111200.PMID 16507574.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000038295–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053626–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10516436-5] Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19".Cytogenet Cell Genet.86(1): 64–65.doi:10.1159/000015412.PMID 10516436.S2CID 42081614.

[entrez-6] "Entrez Gene: TLL1 tolloid-like 1".

[5]

[6]

[1]

[2]

[3]

[4]

TLL1

References

Further reading