TLL2

TLL2
Identifiers
Aliases	TLL2,tolloid like 2
External IDs	OMIM:606743;MGI:1346044;HomoloGene:56545;GeneCards:TLL2;OMA:TLL2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	96,513,926bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,195,274bp
RNA expressionpattern
	Top expressed in
	buccal mucosa cell; ; gonad; ; apex of heart; ; testicle; ; left ventricle; ; Brodmann area 23; ; right ventricle; ; C1 segment; ; middle temporal gyrus; ; muscle of thigh;
	Top expressed in
	embryo; ; tail of embryo; ; esophagus; ; stria vascularis; ; Mesencephalon; ; ovary;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; zinc ion binding; peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; serine-type endopeptidase activity;
Cellular component	extracellular region;
Biological process	multicellular organism development; cell differentiation; extracellular matrix disassembly; negative regulation of skeletal muscle tissue growth; proteolysis;
	Sources:Amigo/QuickGO
Orthologs
	7093
	24087
	ENSG00000095587
	ENSMUSG00000025013
	Q9Y6L7
	Q9WVM6
	NM_012465
	NM_011904
	NP_036597
	NP_036034
	Wikidata
View/Edit Human	View/Edit Mouse

Tolloid-like protein 2is aproteinthat in humans is encoded by theTLL2gene.^[5]^[6]

This gene encodes anastacin-like zinc-dependentmetalloproteaseand is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides orchordin.^[6]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000095587–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000025013–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19".Cytogenet Cell Genet.86(1): 64–5.doi:10.1159/000015412.PMID 10516436.S2CID 42081614.
^^a ^b"Entrez Gene: TLL2 tolloid-like 2".

Nagase T, Ishikawa K, Suyama M, et al. (1999)."Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.6(1): 63–70.doi:10.1093/dnares/6.1.63.PMID 10231032.
Scott IC, Blitz IL, Pappano WN, et al. (1999)."Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis".Dev. Biol.213(2): 283–300.doi:10.1006/dbio.1999.9383.PMID 10479448.
Reynolds SD, Zhang D, Puzas JE, et al. (2000). "Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues".Gene.248(1–2): 233–43.doi:10.1016/S0378-1119(00)00114-1.PMID 10806368.
Hartley JL, Temple GF, Brasch MA (2001)."DNA Cloning Using In Vitro Site-Specific Recombination".Genome Res.10(11): 1788–95.doi:10.1101/gr.143000.PMC310948.PMID 11076863.
Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001)."Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures".J. Biol. Chem.276(25): 22537–43.doi:10.1074/jbc.M102352200.PMID 11313359.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004)."The DNA sequence and comparative analysis of human chromosome 10".Nature.429(6990): 375–81.Bibcode:2004Natur.429..375D.doi:10.1038/nature02462.PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095587–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025013–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10516436-5] Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19".Cytogenet Cell Genet.86(1): 64–5.doi:10.1159/000015412.PMID 10516436.S2CID 42081614.

[entrez-6] "Entrez Gene: TLL2 tolloid-like 2".

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TLL2

References

Further reading