Telepathologyis the practice ofpathologyat a distance. It usestelecommunicationstechnology to facilitate the transfer of image-rich pathology data between distant locations for the purposes ofdiagnosis,education,andresearch.[1][2]Performance of telepathology requires that a pathologist selects thevideoimages for analysis and the rendering of diagnoses.[3]The use of "television microscopy",the forerunner of telepathology, did not require that a pathologist have physical or virtual" hands-on "involvement in the selection of microscopic fields-of-view for analysis and diagnosis.
Anacademicpathologist,Ronald S. Weinstein,M.D., coined the term "telepathology" in 1986. In amedical journaleditorial,Weinstein outlined the actions that would be needed to create remote pathology diagnostic services.[4]He and his collaborators published the first scientific paper on robotic telepathology.[5]Weinstein was also granted the firstU.S.patentsforrobotictelepathology systems and telepathology diagnostic networks.[6]Weinstein is known to many as the "father of telepathology".[7]InNorway,Eide and Nordrum implemented the first sustainable clinical telepathology service in 1989;[8]this is still in operation decades later. A number of clinical telepathology services have benefited many thousands of patients inNorth America,Europe,andAsia.
Telepathology has been successfully used for many applications, including the rendering ofhistopathologytissue diagnoses at a distance. Althoughdigital pathologyimaging, includingvirtual microscopy,is the mode of choice for telepathology services in developed countries,analogtelepathology imaging is still used for patient services in some developing countries.
Types of systems
editTelepathology systems are divided into three major types: static image-based systems,real-time systems,andvirtual slidesystems.
Static image systems have the benefit of being the most reasonably priced and usable systems. They have the significant drawback in only being able to capture a selected subset ofmicroscopicfields for off-site evaluation.
Real-time robotic microscopy systems and virtual slides allow a consultant pathologist the opportunity to evaluate histopathology slides in their entirety, from a distance. With real-time systems, the consultant actively operates a robotically controlled motorizedmicroscopelocated at a distant site—changing focus, illumination, magnification, and field of view—at will. Either an analog video camera or a digital video camera can be used for robotic microscopy. Another form of real-time microscopy involves utilizing a high resolution video camera mounted on a path lab microscope to send live digital video of a slide to a large computer monitor at the pathologist's remote location via encrypted store-and-forward software. An echo-cancelling microphone at each end of the video conference allows the pathologist to communicate with the person moving the slide under the microscope.
Virtual slidesystems utilize automated digital slide scanners that create a digital image file of an entire glass slide (whole slide image). This file is stored on a computer server and can be navigated at a distance, over theInternet,using a browser.[9]Digital imagingis required for virtual microscopy.
While real-time and virtual slide systems offer higher diagnostic accuracy when compared with static-image telepathology, there are drawbacks to each. Real-time systems perform best onlocal area networks(LANs), but performance may suffer if employed during periods of high network traffic or using the Internet proper as a backbone. Expense is an issue with real-time systems and virtual slide systems as they can be costly. Virtual slide telepathology is emerging as the technology of choice for telepathology services. However, high throughput virtual slide scanners (those producing one virtual slide or more per minute) are currently expensive. Also, virtual slide digital files are relatively large, often exceeding onegigabytein size. Storing and simultaneously retrieving large numbers of telepathology whole-slide image files can be cumbersome, introducing their own workflow challenges in the clinical laboratory.
Types of Telepathology Platform: Telepathology platforms that have adopted whole slide imaging enables remote viewing to aid pathologist in following ways: By remote sharing and secondly by uploading images for expert consultations.[10]
Uses and benefits
editTelepathology is currently being used for a wide spectrum of clinical applications including diagnosing offrozen sectionspecimens,[11]primaryhistopathologydiagnoses,[12]second opiniondiagnoses,[13]subspecialty pathology expert diagnoses,[14]investigative and regulated preclinical toxicology studies,[15]education,[16]competency assessment,[17]and research. Benefits of telepathology include providing immediate access to off-site pathologists for rapid frozen section diagnoses. Another benefit can be gaining direct access to subspecialty pathologists such as arenal pathologist,aneuropathologist,or adermatopathologist,for immediate consultations.
Services by country
editCanada
editCanada Health Infowayis the organization responsible for the implementation of telepathology inCanada.Canada Health Infoway is a federal non-profit which provides funding for improving digital health infrastructure.
Canada Health Infoway has targeted funding of $1.2 million CAD to the Telepathology Solution for the province ofBritish Columbia.[18]The system is designed to connect all pathologists within the province. The long-term expectations are improvement to patient care and safety through access to pathology expertise, improved timeliness of results and quality of service.
InOntario,theUniversity Health Network(UHN) hospitals are the primary drivers of the development of telepathology. The three northern Ontario communities ofTimmins,Sault Ste. MarieandKapuskasinghave several community hospitals virtually linked to UHN pathologists via the Internet 24 hours a day.[19]
See also
edit- Anatomical pathology
- Cytopathology
- Digital pathology
- Juan Rosai,a surgical pathology professor working with telepathology
- Medical laboratory
- Microscopy
- Ronald S. Weinstein,an early innovator in telepathology
- Virtual microscope
- Virtual slide
References
edit- ^Weinstein, RS; Graham, AM; Richter, LC; Barker, GP; Krupinski, EA; Lopez, AM; Yagi, Y; Gilbertson, JR; Bhattacharyya, AK; et al. (2009), "Overview of telepathology, virtual microscopy and whole slide imagining: Prospects for the future",Hum Pathol,40(8): 1057–1069,doi:10.1016/j.humpath.2009.04.006,PMID19552937
- ^Kumar S (2009), "Telepathology: An Audit", in Kumar S, Dunn BE (eds.),Tele-pathology,Springer-Verlag, pp. 225–229
- ^Braunhut B, Graham A, Richter L, Webster P, Krupinski E (Sep 2013)."Fifth generation telepathology systems. Workflow analysis of the robotic dynamic telepathology Component".Diagnostic Pathology.8(1): S3.doi:10.1186/1746-1596-8-S1-S3.PMC3849607.
- ^Weinstein, RS (1986), "Prospects for telepathology (Editorial)",Hum Pathol,17(5): 433–434,doi:10.1016/s0046-8177(86)80028-4,PMID3516858
- ^Weinstein, RS; Bloom, KJ; Rozek, LS (1987), "Telepathology and the networking of pathology diagnostic services",Arch Pathol Lab Med,111(7): 646–652,PMID3606341
- ^Kayser, K; Szymas, J; Weinstein, RS (1999),Telepathology: Telecommunications, Electronic Education and Publication in Pathology,Springer, pp. 1–186
- ^"ReUnion '10 award winners".Archived fromthe originalon 2012-08-05.
- ^Nordrum, I; Engum, B; Rinde, E; et al. (1991), "Remote frozen section service: A telepathology project to northern Norway.",Hum Pathol,1991(6): 514–518,doi:10.1016/0046-8177(91)90226-F,PMID1864583
- ^Kayser, K; Molnar, B; Weinstein, RS (2006), "Digital pathology virtual slide technology in tissue-based diagnosis, research and education.",VSV Interdisciplinary Medical Publishing(Berlin): 1–193
- ^"Global Telepath Network".20 February 2019.
- ^Evans, AJ; Chetty, R; Clarke, BA; Croul, S; Ghazarian, DM; Kiehl, TR; Ordonez, BP; Ilaalagan, S; Asa, SL (2009), "Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience",Hum Pathol,40(8): 1069–1081,doi:10.1016/j.humpath.2009.04.012,PMID19540554
- ^Dunn, BE; Choi, H; Recla, DL; Kerr, SE; Wagenman, BL (2009), "Robotic surgical telepathology between the Iron Mountain and Milwaukee Department of Veterans Affairs Medical Centers: a 12-year experience",Hum Pathol,40(8): 1092–1099,doi:10.1016/j.humpath.2009.04.007,PMID19552935
- ^Graham, AR; Bhattacharyya, AK; Scott, KM; Lian, F; Grasso, LL; Richter, LC; Henderson, JT; Carpenter, JB; Lopez, AM; Barker, GP; Weinstein, RS; Weinstein, R. S. (2009), "Virtual slide telepathology for an academic teaching hospital surgical pathology quality assurance program",Hum Pathol,40(8): 1129–1136,doi:10.1016/j.humpath.2009.04.008,PMID19540562
- ^Massone, C; Soyer, HP; Lozzi, GP; DiStefani, A; Leinweber, B; Gabler, G; Asgari, M; Boldrini, R; Bugatti, L; Canzonieri, V; Ferrara, G; Kodama, K; Mehregan, D; Rongioletti, F; Janjua, S. A.; Mashayekhi, V; Vassilaki, I; Zelger, B; Zgavec, B; Cerroni, L; Kerl, H; et al. (2007), "Feasibility and diagnostic agreement in teledermatology using a virtual slide system",Hum Pathol,38(4): 546–554,doi:10.1016/j.humpath.2006.10.006,PMID17270240
- ^Siegel, Gabriel; Regelman, Dan; Maronpot, Robert; Rosenstock, Moti; Hayashi, Shim-mo; Nyska, Abraham (Oct 2018)."Utilizing novel telepathology system in preclinical studies and peer review".Journal of Toxicologic Pathology.31(4): 315–319.doi:10.1293/tox.2018-0032.PMC6206289.PMID30393436.
- ^Dee, FR (2009), "Virtual microscopy in pathology education",Hum Pathol,40(8): 1112–1121,doi:10.1016/j.humpath.2009.04.010,PMID19540551
- ^Bruch, LA; De Young, BR; Kreiter, CD; Haugen, TH; Leaven, TC; Dee, FR (2009), "Competency assessment of residents in surgical pathology using virtual microscopy",Hum Pathol,40(8): 1122–1128,doi:10.1016/j.humpath.2009.04.009,PMID19552936
- ^Information Resource Management Plan 2007/08(PDF),British Columbia Ministry of Health Knowledge Management and Technology Division,retrievedNovember 23,2011
- ^"UHN establishes first telepathology system in Ontario",News Releases,Canada Health Infoway,archived fromthe originalon August 3, 2010,retrievedNovember 23,2011
- Bibliography
- Cross SS, Dennis T, Start RD (2002). "Telepathology: current status and future prospects in diagnostic histopathology".Histopathology.41(2): 91–109.doi:10.1046/j.1365-2559.2002.01423.x.PMID12147086.S2CID38037710.
{{cite journal}}:CS1 maint: multiple names: authors list (link) - Della Mea V, Beltrami CA (2000)."Current experiences with internet telepathology and possible evolution in the next generation of Internet services".Anal Cell Pathol.21(3–4): 127–34.doi:10.1155/2000/836847.PMC4618209.PMID11339559.
- Frierson HF Jr, Galgano MT (2007). "Frozen-section diagnosis by wireless telepathology and ultra portable computer: use in pathology resident/faculty consultation".Hum Pathol.38(9): 1330–4.doi:10.1016/j.humpath.2007.02.006.PMID17555793.
- Halliday BE, Bhattacharyya AK, Graham AR, et al. (1997). "Diagnostic accuracy of an international static-imaging telepathology consultation service".Hum Pathol.28(1): 17–21.doi:10.1016/s0046-8177(97)90273-2.PMID9013826.
- Kaplan KJ, Burgess JR, Sandberg GD, et al. (2002).""Use of robotic telepathology for frozen-section diagnosis" a retrospective trial of a telepathology system for intraoperative consultation ".Mod Pathol.15(11): 1197–1204.doi:10.1097/01.mp.0000033928.11585.42.PMID12429799.
- Krupinski E, Weinstein RS, Bloom KJ, Rozek LS (1993). "Progress in telepathology: System implementation and testing".Advances in Path Lab Med.6:63–87.
- Krupinski EA (2009). "Virtual slide telepathology workstation-of-the-future: lessons learned from teleradiology".Semin Diagn Pathol.26(8): 194–205.doi:10.1053/j.semdp.2009.09.005.PMID20069781.S2CID4742040.
- Leung ST, Kaplan KJ (2009). "Medicolegal aspects of telepathology".Hum Pathol.40(8): 1137–1142.doi:10.1016/j.humpath.2009.01.009.PMID19368955.
- Maiolino P, De Vico G. Telepathology in veterinary diagnostic cytopathology. In: Kumar S, Dunn BE, editors. Telepathology. Berlin, Springer, 2009; 6:63-69.
- Nordrum I, Eide TJ (1995). "Remote frozen section service in Norway".Arch Anat Cytol Pathol.43(4): 253–256.PMID8526562.
- O'Malley DP (2008). "Practical applications of telepathology using morphology-based anatomic pathology".Arch Pathol Lab Med.132(5): 743–4.doi:10.5858/2008-132-743-PAOTUM.PMID18466015.
- Schroeder JA. Ultrasructural telepathology: remote EM diagnostic via Internet. In: Kumar S, Dunn BE, editors. Telepathology. Berlin, Springer, 2009; 14:179-204.
- Sinard JH. Practical pathology informatics. New York, Springer. 2006:265-286.
- Weinstein RS (1986). "Prospects for telepathology. (Editorial)".Human Path.17(5): 433–434.doi:10.1016/s0046-8177(86)80028-4.PMID3516858.
- Weinstein RS, Bhattacharyya AK, Graham AR, et al. (1997). "Telepathology: a ten-year progress report".Hum Pathol.28(1): 1–7.doi:10.1016/s0046-8177(97)90270-7.PMID9013823.
- Weinstein RS, Bloom KJ, Rozek LS (1987). "Telepathology and the networking of pathology diagnostic services".Arch Pathol Lab Med.111(7): 646–652.PMID3606341.
- Weinstein RS, Descour MR, Liang C, et al. (2001). "Telepathology overview: from concept to implementation".Hum Pathol.32(12): 1283–99.doi:10.1053/hupa.2001.29643.PMID11774159.
- Weinstein RS, Graham AM, Richter LC, Barker GP, Krupinski EA, Lopez AM, Erps KA, Yagi Y, Gilbertson JR, Bhattacharyya AK (2009). "Overview of telepathology, virtual microscopy and whole slide imagining: Prospects for the future".Hum Pathol.40(8): 1057–1069.doi:10.1016/j.humpath.2009.04.006.PMID19552937.
- Williams S, Henricks WH, Becich MJ, et al. (2010). ""Telepathology for patient care" what am I getting myself into? ".Adv Anat Pathol.17(2): 130–49.doi:10.1097/pap.0b013e3181cfb788.PMID20179435.S2CID41856327.
External links
edit- Organizing Knowledge in a Semantic Web for Pathology
- Welcome to Digital Pathology at Brown Medical School
- Holycross Cancer Center (Poland, Kielce) Pathomorphology Department virtual slides
- Digital pathology: DICOM-conform draft, testbed, and first results
- OpenSlide - C library that provides a simple interface to read whole-slide images.