In the field ofmolecular biology,trans-acting(trans-regulatory,trans-regulation), in general, means "acting from a different molecule" (i.e.,intermolecular). It may be considered the opposite ofcis-acting(cis-regulatory,cis-regulation), which, in general, means "acting from the same molecule" (i.e.,intramolecular).
In the context oftranscriptionregulation, atrans-acting factoris usually a regulatoryproteinthat binds toDNA.[1]The binding of atrans-acting factor to acis-regulatory element inDNAcan cause changes in transcriptional expression levels.microRNAsor other diffusible molecules are also examples oftrans-acting factors that can regulate target sequences.[2] Thetrans-acting gene may be on a differentchromosometo the target gene, but the activity is via the intermediary protein or RNA that it encodes.Cis-actingelements, on the other hand, do not code for protein or RNA. Both thetrans-acting gene and the protein/RNA that it encodes are said to "act intrans"on the target gene.
Transcription factorsare categorized as trans-acting factors.
See also
editReferences
edit- ^Brooker, Robert J.Genetics: analysis and principles(6th ed.). New York, NY: McGraw-Hill Education.
- ^Watson, James D.;Caudy, Amy A; Myers, Richard M.; Witkowski, Jan A. (2007).Recombinant DNA: Genes and Genomes - A Short Course.Cold Spring Harbor Press. pp. 57–58.ISBN978-0-7167-2866-5.
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